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| Number | Title | Issue Date |
| 7413865 | Diagnostic method for a transmissible spongiform encephalopathy or prion disease A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or plat... | 08/19/2008 |
| 7358039 | Fixed-dried red blood cells Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenici... | 04/15/2008 |
| 7293985 | Methods for quenching pathogen inactivators in biological materials Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials comprising red blood cells. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating comp... | 11/13/2007 |
| 7267817 | Method for improving oxygen transport by stored red blood cells A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solutio... | 09/11/2007 |
| 7179615 | Method of prophylaxis and treatment The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method for the prophylaxis and treatment of Plasmodium infection in mam... | 02/20/2007 |
| 7144978 | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunolog... | 12/05/2006 |
| 7125897 | Combined therapies for atherosclerosis treatment There is provided a combination treatment for slowing or arresting the progression and/or effecting the regression of atherosclerotic plaque deposits in a mammalian patient, said combination treatment including the administration to the patient of a cholesterol lowe... | 10/24/2006 |
| 7037500 | Method for using phagocytic particles and ATP receptors to deliver antigens to MHC class I receptors to induce immunity against microbial pathogens or tumors or to suppress immunity This invention provides methods of delivering an antigen to an Class I or Class II MHC receptors to induce immunity against the antigen in a subject having a disease. This invention also provides methods of delivering an antigen to an Class II or class I MHC recepto... | 05/02/2006 |
| 6962787 | Diagnostic method for a transmissible spongiform encephalopathy or a prion disease A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or plat... | 11/08/2005 |
| 6946127 | Decorated red blood cells Disclosed are modified red blood cells which function as deployment platforms for important biomolecules. Such modified red blood cells can confer, for example, in vivo protection against exposure to an otherwise lethal nerve agent. ... | 09/20/2005 |
| 6942859 | Red blood cells covalently bound with polymers Living cells modified at their surface with specially selected polymers are disclosed. A simple method to covalently attach specially selected PEG derivatives to the surface of RBC in aqueous media under mild conditions is a preferred example. The selected PEG-modif... | 09/13/2005 |
| 6916471 | Red blood cells loaded with S-nitrosothiol and uses therefor Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized b... | 07/12/2005 |
| 6884573 | Fixed dried red blood cells and method of use Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenici... | 04/26/2005 |
| 6869602 | Method for treating, preventing, or inhibiting enterotoxigenic Escherichia coli infections with bovine red blood cells Disclosed herein are RBC preparations and methods of making and using thereof for treating, preventing or inhibiting ETEC infections. In particular, bovine red blood cell (RBC) preparations are shown to reduce enterotoxigenic Escherichia coli (ETEC) adhesion ... | 03/22/2005 |
| 6821513 | Method for enhancing hematopoiesis A method is provided for enhancing hematopoiesis. The method includes transplanting at least a therapeutically effective portion of an isolated vascular tissue into a subject, wherein the vascular tissue enhances hematopoiesis. A method is also provided for detectin... | 11/23/2004 |
| 6811778 | Method for improving oxygen transport by stored red blood cells A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solutio... | 11/02/2004 |
| 6770276 | Insulin-containing medicament for peroral application and method for the production thereof The invention refers to medical science and deals with insulin-containing medicine for peroral use and its derivation method. Insulin-containing medicine for peroral use containing insulin and auxiliary substance, wherein it contains insulin immobilized on er... | 08/03/2004 |
| 6540999 | Immunomodulatory methods using Lewisx oligosacchardies Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least ... | 04/01/2003 |
| 6506381 | Modified red blood cell that has surface molecules that neutralize chemical agents Disclosed are modified red blood cells which function as deployment platforms for important biomolecules. Such modified red blood cells can confer, for example, in vivo protection against exposure to an otherwise lethal nerve agent.... | 01/14/2003 |
| 6455306 | Transfusable oxygenating composition The present invention relates to a process for producing a transfusable, oxygenating composition of human red blood cells by the ex vivo culturing, expansion and differentiation of human primitive hematopoietic cells. The process involves expansion of pri... | 09/24/2002 |
| 6383481 | Method for transplantation of hemopoietic stem cells This invention relates to a method of transplanting hemopoietic stem cells which Comprises subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell transplantation in advance and administering hemopoietic ... | 05/07/2002 |
| 6312685 | Red blood cells covalently bound with two different polyethylene glycol derivatives Living cells are modified at their surface with specially selected polymers. Covalently attaching specially selected polyethylene glycol (PEG) derivatives to the surface of red blood cells (RBC) in aqueous media under mild conditions is a preferred exampl... | 11/06/2001 |
| 6255278 | Composition containing pooled transferrins as an active principle for the induction of immune tolerance against antigens A method for controlling immune reactions to a foreign tissue or a foreign cell in a recipient host mammal to enhance tolerance of the recipient host mammal towards a grafted foreign tissue or a grafted foreign cell. This method involves administering a t... | 07/03/2001 |
| 6203789 | Red blood cells loaded with S-nitrosothiol and uses therefor Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are char... | 03/20/2001 |
| 6153186 | Red blood cells loaded with S-nitrosothiol and uses therefor Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to cysteine residues, thereby shielding the NO functionality from heme inactivation. S-nitrosylation of Hb is under th... | 11/28/2000 |
| 6139836 | Method of encapsulating biologically active agents within erythrocytes, and apparatus therefor A method and apparatus for the encapsulation of biologically active agents in red blood cells (RBCS) is disclosed. The method is characterized in that lysed and partially lysed RBCs are concentrated prior to the introduction of the biologically active age... | 10/31/2000 |
| 6129912 | Polyethylene glycol-protein compositions which reduce the antigenic display of red blood cells The present invention provides a composition of matter, comprising a red blood cell coated a polymeric mixture of polyethylene glycol and albumin. Also provided is a method of blocking blood group antigens on the surface of a red blood cell, comprising th... | 10/10/2000 |
| 6087087 | Treatment of hemoglobin with nitric oxide Methods and compositions are provided for treating diluents (including whole blood or at least one blood component) comprising hemoglobin containing erythrocytes (i.e., red blood cells), in order to increase the oxygen delivery capacity of the hemoglobin,... | 07/11/2000 |
| 6030768 | Analysis of conformational changes in band 3 protein as a method for diagnosing Alzheimer's disease A method diagnosing Alzheimer's disease in a patient includes analyzing conformational changes in a band 3 protein of the patient yielding a time course of the conformational changes. One approach includes analyzing conformational changes in a band 3 prot... | 02/29/2000 |
| 6020120 | Use of N-acetylcysteine to store red blood cells and a method of aging red cells with nitrogen The invention provides a method of preserving red blood cells. The method comprises treating the red blood cells with about 2 mM to about 35 mM of N-acetylcysteine. The invention further provides a method of aging red blood cells. This method comprises is... | 02/01/2000 |
| 5906915 | Method for storing red cells using reduced citrate anticoagulant and a solution containing sodium, citrate, phosphate, adenine and mannitol The present invention provides an improved aqueous solution for suspending and storing red blood cells. The solution includes sodium citrate, a combination of sodium biphosphate and sodium phosphate dibasic, adenine, and mannitol. The solution is formulat... | 05/25/1999 |
| 5882934 | Composition and method for hemoglobin and cell analysis A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of leukocyte subpopulations are described. The cyanide-free lytic re... | 03/16/1999 |
| 5866428 | Cyanide-free reagent and method for the determination of hemoglobin A cyanide-free method and reagent for determining the concentration of total hemoglobin in a whole blood sample accurately in less than 10 seconds including a ligand selected from the group consisting of imidiazole, imidazole derivatives, N-hydroxyacetami... | 02/02/1999 |
| 5856360 | Pharmaceutical method for the treatment of severe blood loss and for the inhibition or treatment of hemorrhagic shock This invention is directed to a pharmacologically acceptable composition for inhibiting or treating hemorrhagic shock in a mammal. The composition includes a KATP inhibitor and a pharmacologically acceptable carrier, with the KATP in... | 01/05/1999 |
| 5827644 | Thiazine dyes used to inactivate HIV in biological fluids A method for using thiazine dyes, especially methylene blue, alone or in combination with low levels of light, to selectively inactivate or inhibit intracellular replication of specific viruses, especially human immunodeficiency virus. Examples of useful ... | 10/27/1998 |
| 5811301 | In vitro method for producing differentiated universally compatible human blood cells In vitro production of clinically useful quantities of single species of mature, differentiated human blood cells is carried out by a method in which human pluripotent hematopoietic stem cells, preferably from a universal donor, are incubated in a bioreac... | 09/22/1998 |
| 5763280 | Cyanide-free lytic reagent composition and method for hemoglobin and cell analysis A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of three leukocyte subpopulations including lymphocytes, monocytes, ... | 06/09/1998 |
| 5753221 | Transformed erythrocytes, process for preparing the same, and their use in pharmaceutical compositions The invention relates to compositions of erythrocytes that have been modified following hypotonic lysis and resealing by addition of 2',3'-dideoxycytidine-5'-triphosphate (ddCTP) or 3'-azido-3'-deoxythymidine-5'-triphosphate (AZT-TP). These compositions ... | 05/19/1998 |
| 5716616 | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngen... | 02/10/1998 |
| 5691132 | Method for inactivating pathogens in red cell compositions using quinacrine mustard Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques... | 11/25/1997 |
