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| Number | Title | Issue Date |
| 8153120 | Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity The present invention relates to the discovery of novel methods of inducing a natural killer (NK) cell-mediated immune response and increasing NK activity in a mammal for the treatment of tumors and virus infections. The method comprises the steps of isolating perip... | 04/10/2012 |
| 8101173 | Method for treating urinary bladder cancer The present invention discloses an immunotherapeutic method for treating a patient suffering from urinary bladder cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes drain... | 01/24/2012 |
| 8075882 | Adoptive immune cells for tumor vaccines Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a culture vessel coated with a sugar chain-containing polymer; and (c) ... | 12/13/2011 |
| 8066989 | Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy The present invention refers to a method of treating tumor growth and metastasis in a mammal, the treating comprising administering allogeneic effector cells together with trifunctional bispecific or trispecific antibodies or a combination thereof having the followi... | 11/29/2011 |
| 8021658 | Alternative splice forms of proteins as basis for multiple therapeutic modalities Peptides or antibodies derived from alternative splice forms of proteins associated with a disease or physiologic condition are used as therapeutic or prophylactic agents. Peptides and antibodies derived from alternative splice forms of the vascular endothelial grow... | 09/20/2011 |
| 8012470 | Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumor cells; b) treating the tumor cells to prevent t... | 09/06/2011 |
| 8007785 | Method for treating colon cancer with tumour-reactive T-lymphocytes The present invention discloses an immunotherapeutic method for treating patients suffering from colon cancer, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a tumo... | 08/30/2011 |
| 8003093 | B cell-based vaccine loaded with the ligand of natural killer T cell and antigen The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic and prophylactic vaccine mediated by B cells loaded with α-galactos... | 08/23/2011 |
| 7988963 | Use of allogeneic cell lines to load antigen presenting cells to elicit or eliminate immune responses Novel antigen-presenting cells, including but not limited to dendritic cells, that are loaded with antigens from dead or dying cells including allogenic cell lines, and the methods for making such antigen-presenting cells are described. These loaded antigen-presenti... | 08/02/2011 |
| 7985409 | Tr1 cells for use in atherosclerosis The present invention relates to a method of treating or preventing atherosclerosis comprising administering to a mammal in need of such a treatment a) an antigen which has been used to activate in vitro a Tri cell population originating from said mammal, and b) the... | 07/26/2011 |
| 7972594 | Ablative immunotherapy The invention disclosed herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues by first priming patients with allogeneic cells designed to be rejected by a Th1 mediated mechanis... | 07/05/2011 |
| 7951365 | Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with specific cancer types Methods for treating a patient suffering from a neoplastic disease are disclosed and described. A number of diseases can be treated under the present methods, including without limitation gall bladder cancer, hepato cellular cancer, ovarian cancer, small intestine c... | 05/31/2011 |
| 7901673 | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an... | 03/08/2011 |
| 7871606 | Use of stimulated peripheral-blood mononuclear cells for the treatment of cancerous diseases The invention relates to the use of peripheral-blood mononuclear cells that have been stimulated via cascade priming (CAPRI cells) for the purpose of providing an agent for the treatment of cancerous diseases. The CAPRI cells may also be administered in combination ... | 01/18/2011 |
| 7837990 | In vivo expanded NKT cells and methods of use thereof This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing α-galactosyl ceramide and to methods of use thereof in modulating immune responses, such as anti-cancer responses, and enhancing memory responses. | 11/23/2010 |
| 7785583 | In situ maturation of dendritic cells A method for eliciting an immune response to an antigen in a subject via (a) loading isolated antigen presenting cells with an antigen ex vivo; and (b) administering the antigen presenting cells to a subject at a pre-treated site. ... | 08/31/2010 |
| 7763243 | In situ immunization The arming of activated T cells (ATC) with BiAbs can overcome major barriers for successful adoptive immunotherapy. The BiAb approach takes the advantage of the targeting specificity of monoclonal antibodies and the cytotoxic capacity of T cells to lyse tumors. Armi... | 07/27/2010 |
| 7731953 | Methods for use of TSLP and agonists and antagonists thereof Methods are disclosed herein for specifically inducing proliferation of CD4+ T cells. The methods are of use in treating immunodeficiencies, such as an immunodeficiency produced by infection with an immunodeficiency virus, such as infection with a human i... | 06/08/2010 |
| 7727523 | Method for suppressing immune system response to transplanted tissue or cells Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate ... | 06/01/2010 |
| 7722862 | Regulatory T cells suppress autoimmunity The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods of use. ... | 05/25/2010 |
| 7695713 | Isolation and identification of T cells The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as multiple sclerosis or rheumatoid arthritis using autologous T cell vacc... | 04/13/2010 |
| 7651685 | Use of microchimeric cells in the treatment of malignancy Methods and formulations for the treatment of malignancies. Assessment of the incidence and scope of MC in control and cancer populations provides for the development of cellular therapy approaches to hematologic malignancies that are expected to be well tolerated i... | 01/26/2010 |
| 7638122 | Stat3 antagonists and their use as vaccines against cancer The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and... | 12/29/2009 |
| 7560105 | Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in a host. In one aspect, the invention provides a method for generating... | 07/14/2009 |
| 7488474 | Method for detecting regulatory T cells using expression of folate receptor 4 as indicator, method for treating diseases using the detection method, pharmaceutical composition for immunostimulation, and method for treating diseases using the composition An object of the present invention is to provide a technique to distinguish between Treg cells and activated T cells in a live state. Another object of the present invention is to provide a pharmaceutical composition for immunostimulation that can reduce ... | 02/10/2009 |
| 7479269 | Methods for selectively enriching TH1 and TH2 cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 01/20/2009 |
| 7419660 | Vaccines for treatment of lymphoma and leukemia The present invention provides multivalent vaccines for the treatment of B-cell malignancies (e.g., lymphomas and leukemias). The present invention also provides methods for the production of custom vaccines, including multivalent vaccines for the treatment of immun... | 09/02/2008 |
| 7413865 | Diagnostic method for a transmissible spongiform encephalopathy or prion disease A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or plat... | 08/19/2008 |
| 7413869 | Method for determining potency of antigenic presenting cell based vaccines The present invention discloses methods useful in the preparation of immunostimulatory vaccines which include as one of their components, activated antigen presenting cells which are characterized by having an ability to stimulate a therapeutic T cells response in v... | 08/19/2008 |
| 7402430 | MHC class II antigen-presenting systems and methods for activating CD4T cells The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matric... | 07/22/2008 |
| 7402307 | Method for identifying and killing cancer cells The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DC may be pulsed wit... | 07/22/2008 |
| 7378089 | Gene therapy for the prevention of autoimmune disease Autoimmune disease is treated by the delivery of a suppressive agent to the site of disease. Delivery is accomplished by introducing an expression vector encoding the suppressive agent into cells targeted for such sites, and administering the genetically modified ce... | 05/27/2008 |
| 7364741 | Peptides of human Papilloma virus for use in human T cell response inducing compositions A peptide comprising an amino acid sequence derived from a human papilloma virus (HPV) protein, wherein said amino acid sequence has the ability to bind to a human Major Histocompatibility Complex Class I molecule. Its use in prophylactic or therapeutic treatment of... | 04/29/2008 |
| 7351409 | Tumor antigens and CTL clones isolated by a novel procedure The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by su... | 04/01/2008 |
| 7332295 | Multidimensional leukocyte differential analysis This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells, including the quantification of each subpopulation in terms of cells pe... | 02/19/2008 |
| 7332158 | Compositions and treatments for myelosuppression by ex vivo activated immune cells The disclosure includes protocols of activating and administering human blood cells to myelosuppressed patients, including patients treated for cancer, e.g., by chemotherapy or radiation. The protocol may include culturing blood cells in the presence of a cytokine a... | 02/19/2008 |
| 7332298 | Nucleic acids encoding multimeric proteins of TNF superfamily ligands A method for constructing stable bioactive fusion proteins of the difficult to express tum or necrosis factor superfamily (TNFSF), and particularly members CD40L (CD 154) and RANKL/TRANCE, with collectins, particularly pulmonary surfactant protein D (SPD) is describ... | 02/19/2008 |
| 7326529 | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer The present invention provides new markers and methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer. ... | 02/05/2008 |
| 7300774 | Multimeric fusion proteins of the TNF superfamily ligands A method for constructing stable bioactive fusion proteins of the difficult to express tumor necrosis factor superfamily (TNFSF), and particularly members CD40L (CD154) and RANKL/TRANCE, with collecting, particularly pulmonary surfactant protein D (SPD) is described... | 11/27/2007 |
| 7294331 | Methods of using flt3-ligand in hematopoietic cell transplantation Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to Flt3-ligand as an isolated protein, the DNA encoding the Fl... | 11/13/2007 |
