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| Number | Title | Issue Date |
| 8092793 | Treating inflammatory bowel disease with live bacteria This invention relates to using live beneficial bacteria for treating inflammatory bowel disease, such as ulcerative colitis and Crohn's disease. ... | 01/10/2012 |
| 8007782 | Combination bacteriolytic therapy for the treatment of tumors Current approaches for treating cancer are limited, in part, by the inability of drugs to affect the poorly vascularized regions of tumors. We have found that spores of anaerobic bacteria in combination with agents which interact with microtubules can cause the dest... | 08/30/2011 |
| 7785581 | Composition and method for reducing feces toxins and treating digestive disorders This invention relates to a method of lowering feces toxin levels and treating digestive disorders (e.g., Irritable Bowel Syndrome or diarrhea) with a composition containing a live beneficial bacterium, a prebiotic, or both. This method includes first identifying a ... | 08/31/2010 |
| 7344710 | Combination bacteriolytic therapy for the treatment of tumors Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively... | 03/18/2008 |
| 7011826 | Control of acidosis The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof, wherein said microorganism is capable of producing lactic acid within the... | 03/14/2006 |
| 6984513 | Anaerobe targeted enzyme-mediated prodrug therapy Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composi... | 01/10/2006 |
| 6743430 | Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a protective antigen component of a non-clostridial organism and an adjuvant. | 06/01/2004 |
| 6652849 | Anaerobe targeted enzyme mediated prodrug therapy A genetically-engineered anaerobic organism is provided which, under anaerobic conditions present in a solid tumor, produces an enzyme capable of catalyzing the conversion of a prodrug to its highly cytotoxic product in situ and methods of treating tumors... | 11/25/2003 |
| 6099833 | Method for inhibiting production of toxins from enteropathogenic escherichia coli, and butyric-acid bacteria and butyric-acid bacteria containing pharmaceuticals used in combination with antibiotics for the method A method of treating a human infected with enteropathogenic Escherichia coli which produces toxins, by administering to the human a butyric-acid bacteria and an antibiotic, such as fosfomycin.... | 08/08/2000 |
| 6036953 | Heterologous antigens in live cell V. cholerae strains Disclosed is a V. cholerae cell containing a DNA encoding a fusion polypeptide that includes a heterologous antigenic polypeptide sequence such as a portion of C. difficile toxin A. The fusion polypeptide also includes one of the following: (i) an E. coli... | 03/14/2000 |
| 5989566 | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solve... | 11/23/1999 |
| 5807757 | Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a solution containing a salt of a monovalent ion such as a salt ... | 09/15/1998 |
| 5800821 | Bacterial spores as a heat stable vaccine delivery system A method of stimulating a vertebrate animal to produce an immune response to at least one antigen is described. The method includes genetically engineering a bacterial cell with DNA encoding at least one antigen and inducing the bacterial cell to sporulat... | 09/01/1998 |
| 5767090 | Microbially produced rhamnolipids (biosurfactants) for the control of plant pathogenic zoosporic fungi Disclosed is the use of biosurfactants as biological control products. In particular, rhamnolipid biosurfactants produced by Pseudomonas spp. were demonstrated to rapidly kill zoospores by rupturing the plasma membrane of three representative zoosporic pl... | 06/16/1998 |
| 5756088 | Prescription diet composition for treatment of dog and cat dermatosis The present invention provides a prescription diet composition containing a poly-unsaturated fatty acid such as γ-linolenic acid, -linolenic acid and docosahexaenoic acid, and/or biotin, and an antiflatulent such as a lactic acid bacterium, a Bifi... | 05/26/1998 |
| 5648264 | Thermocellulolytic bacteria and their uses Clostridium thermocellum biovar. nov. SK522 (FERM BP-345 g) is a thermophilic cellulose decomposing bacteria, capable of solubilizing lignin and fermenting cellulose excellently. Although its temperature limit for growth is 40°-80° C., it grows best at ... | 07/15/1997 |
| 5593883 | Ancient microorganisms The recovery of live ancient bacteria, fungi and other biological material from various sources fossilized in amber or related resins is described. Several ancient bacterial strains have been classified as related to various species of the modern genus Ba... | 01/14/1997 |
| 5266315 | Composite for Clostridium difficile diarrhea and pseudomembranous colitis A preventive and curative medical composition for Clostridium difficile diarrhea and psedomembranous colitis, which composition comprises cells or spores of a butyric acid bacterium and Vancomycin.... | 11/30/1993 |
| 4996055 | Deodorized bacteria composition A deodorant has the genus butyric acid bacteria and the genus Bacillus subtilis as effective components and is used for deodorizing the excrement of various animals and other sources of foul odors. The combined use of the genus butyric acid bacteria and t... | 02/26/1991 |
| 4975105 | Method for coating bareroot plants with a live microbial colony The present invention provides a method for developing a culture of microorganisms in the rhizosphere of plants by dipping roots of the plants in a hydrated super absorbant polymer containing living microorganisms, thereby adhering the polymer to the root... | 12/04/1990 |
| 4892731 | Biological intestinal antiseptics Cells or endospores of a butyric-acid bacterium Clostridium butyricum MII588-Sens 1 strain, or cells or endospores of a butyric-acid bacterium Clostridium butyricum MII588-Res 1 strain are effective as a biological intestinal antiseptic.... | 01/09/1990 |
| 4689226 | Process for the production of a bacterial preparation for the prophylaxis of intestinal disturbances in poultry The invention provides a bacterial preparation for the prophylaxis of intestinal disturbances, especially salmonella infections, in poultry, made by anaerobically cultivating either separately or together bacterial strains of normal alimentary tract bacte... | 08/25/1987 |
