Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 7674455 | Targeted retrograde gene delivery to motor neurons Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to th... | 03/09/2010 |
| 7674454 | Enzyme-prodrug therapy for prosthetic joint repair The invention relates to the use of gene therapy in the treatment of aseptic loosening of orthopaedic prostheses and discloses methods of refixing such prostheses without open revision surgery. In particular, it provides adenoviral vectors and prodrugs for simultane... | 03/09/2010 |
| 7666405 | Deleted adenovirus vectors and methods of making and administering the same The present invention provides deleted adenovirus vectors. The inventive adenovirus vectors carry one or more deletions in the IVa2, 100K, polymerase and/or preterminal protein sequences of the adenovirus genome. The adenoviruses may additionally contain other delet... | 02/23/2010 |
| 7666404 | Glanders/meliodosis vaccines The present invention relates to nucleic acids encoding B. mallei and B. pseudomallei AHL synthases and LuxR transcriptional regulators, and methods for use, as well as describes the construction, characterization and use of avirulent strains of B. ... | 02/23/2010 |
| 7645446 | Glutamic acid decarboxylase (GAD) based delivery system The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions us... | 01/12/2010 |
| 7638119 | Method of diminishing the symptoms of neurodegenerative disease A method of diminishing the symptoms of neurodegenerative disease in a patient is disclosed. In one embodiment, the method comprises the steps of: (a) identifying a patient with a neurodegenerative disease, (b) producing a cell culture, wherein the cell culture comp... | 12/29/2009 |
| 7608256 | Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type... | 10/27/2009 |
| 7608255 | Replication-competent anti-cancer vectors Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and ... | 10/27/2009 |
| 7601342 | Cell fusions and methods of making and using the same The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive immunotherapy. The fusions according to the invention can also be used in methods... | 10/13/2009 |
| 7588757 | Methods of treating Parkinson's disease using recombinant adeno-associated virus virions Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous system of a primate. Once delivered, the genes are expressed, which ... | 09/15/2009 |
| 7588756 | Treatment of cardiac power failure The invention relates to medicaments for treating cardiac power failure. The medicaments contain a therapeutically effective quantity of one or more S100 protein(s) or one or more mutant or fragments of the same, or contain one or more nucleic acid sequence(s) which... | 09/15/2009 |
| 7585497 | Induction of apoptosis and cell growth inhibition by protein 4.33 There is disclosed an isolated cDNA sequence (SEQ ID NO:1) encoding a P4.33 polypeptide and comprising a coding region (SEQ ID NO:2) of the sequence described in SEQ ID NO:1, or a sequence having at least 90% homology with the coding region of SEQ ID NO:1. The P4.33... | 09/08/2009 |
| 7585498 | Regulation of adenovirus DNA packaging by IPTG The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention comprise a binding site of the E. coli Lac repressor protein embed... | 09/08/2009 |
| 7582290 | Packaging cell line for diphtheria toxin expressing non-replicating adenovirus The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria tox... | 09/01/2009 |
| 7572438 | Mutant having uracil phosphoribosyl transferase activity The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a vi... | 08/11/2009 |
| 7569219 | Recombinant double-stranded RNA phage, and use of the same A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactiv... | 08/04/2009 |
| 7569217 | Porcine adenovirus E1 and E4 regions The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 region, is described herein. Methods... | 08/04/2009 |
| 7569218 | Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses Methods of delivering a desired polypeptide to an individual are disclosed. The methods comprise administering to the individual an immunogenic vector comprising a nucleic acid encoding the desired polypeptide operably linked to regulatory elements in combination wi... | 08/04/2009 |
| 7534425 | Animal model and cell-line expressing modified chlorine channel The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which influence endo/exocytosis, which influence processing of proteins and... | 05/19/2009 |
| 7531167 | Herpes simplex virus vector The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55. ... | 05/12/2009 |
| 7521043 | Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines The present invention provides methods for treating tumors, which comprise the step of administering into tumor sites a minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells introduced with the vector. The present invention also provides comp... | 04/21/2009 |
| 7517520 | Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-fr... | 04/14/2009 |
| 7510706 | Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene... | 03/31/2009 |
| 7498024 | Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allow... | 03/03/2009 |
| 7485291 | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof Single vector constructs for expression of a functional antibody molecule are described. The vectors have a self-processing cleavage site between two heterologous DNA coding sequences allowing for expression of two coding sequences using a single promoter. Exemplary... | 02/03/2009 |
| 7476382 | Reovirus for the treatment of neoplasia Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can b... | 01/13/2009 |
| 7473419 | Intravascular delivery of nucleic acid Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the ... | 01/06/2009 |
| 7473418 | Pan cancer oncolytic vectors and methods of use thereof Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replica... | 01/06/2009 |
| 7470426 | Treatment of neoplasms with viruses The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are us... | 12/30/2008 |
| 7468182 | nucleic acids and uses thereof Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinan... | 12/23/2008 |
| 7468181 | Means and methods for the production of adenovirus vectors The invention relates to methods and means for the production of adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenoviral vector and wherein the E4-orf6 gene product ... | 12/23/2008 |
| 7465442 | Reduction of dermal scarring Methods and compositions for reducing or inhibiting dermal scarring by expressing p21WAF1/Cip1 in a wound site are provided. ... | 12/16/2008 |
| 7462351 | Nucleic acid delivery The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, dem... | 12/09/2008 |
| 7459154 | Methods and reagents for the enhancement of virus transduction in the bladder epithelium Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Altern... | 12/02/2008 |
| 7459153 | Viral vectors for gene therapy Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural origin, such as glioblastoma, neuroblastoma and medulloblastoma. The fac... | 12/02/2008 |
| 7452530 | Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically acceptable carrier. In particular this invention provides methods for tr... | 11/18/2008 |
| 7452531 | Compositions and methods for tumor-targeted delivery of effector molecules The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor. The primary effector molecule(s) of the invention is used in the method... | 11/18/2008 |
| 7449178 | Attenuated gram negative bacteria Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99... | 11/11/2008 |
| 7442540 | Polynucleotide encoding coleopteran-toxic polypeptide Disclosed are novel insecticidal polypeptides, and compositions comprising these polypeptides, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed host cells, and transgenic plants that contain nucleic acid segments t... | 10/28/2008 |
| 7438918 | Lipid A deficient mutants of The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells. ... | 10/21/2008 |