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| Number | Title | Issue Date |
| 8110183 | Method for sustained expression of an exogenous gene A method for sustained expression of an exogenous gene forms a circular episomal plasmid to solve the problem of transient expression of baculovirus in the transduced mammalian cells caused by the dilution and degradation when mammalian cells replicate and also prev... | 02/07/2012 |
| 8105574 | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. ... | 01/31/2012 |
| 8105575 | Expression vectors with improved safety The present invention relates to the use of internal promoters in mammalian expression vectors including plasmid vectors and enhancer-deleted retroviral vectors. The retroviral vectors have improved safety and optimal levels of transgene expression and vector titers... | 01/31/2012 |
| 8101169 | Ocular gene therapy using avalanche-mediated transfection The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field in... | 01/24/2012 |
| 8092791 | Method of producing herpes simplex virus amplicons, resulting amplicons, and their use The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector comprising an HSV origin of replication, an HSV cleavage/packaging signal, and... | 01/10/2012 |
| 8084024 | Method for producing antibodies The present invention relates to a method for producing antibodies and to antibodies produced by this method. In one embodiment the invention relates to a method for producing an antibody that binds to a polypeptide of a first species, the method comprising immunizi... | 12/27/2011 |
| 8075879 | mutants and methods Certain attenuated mutants of Brucella, especially B. melitensis, B. abortus, B. suis and B. ovis, when administered to a human or animal trigger a protective immune response such that subsequent challenge with virulent Brucella of the sa... | 12/13/2011 |
| 8076305 | Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify Ih when compared with wild-... | 12/13/2011 |
| 8071084 | Vaccine for protection against disease Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis. ... | 12/06/2011 |
| 8058248 | Foot and mouth disease virus vaccine comprising interferons Early protection of susceptible animals against foot and mouth disease (FMD) may be achieved by inoculating the animals with a vaccine comprising an interferon DNA sequence. One day after inoculation, animals have been found protected from challenge with virulent fo... | 11/15/2011 |
| 8052965 | Viruses with enhanced lytic potency Described is a replication competent recombinant virus, being capable to replicate and having lytic capacity in target cells, the said cell being hampered in the p53 dependent apoptosis pathway, the virus including in the genome thereof, the coding sequence of at le... | 11/08/2011 |
| 8052967 | Stable adenoviral vectors and methods for propagation thereof Provided are methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B-55K region in the recombinant adenoviral vector or b... | 11/08/2011 |
| 8052966 | Methods and compositions for treating metastatic cancer Methods and compositions for producing targeted delivery vectors are provided. Such vectors are useful for treating neoplastic disorders. Also provided are protocols for administering targeted delivery vectors in a clinical setting such that a therapeutic effect is ... | 11/08/2011 |
| 8048410 | In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral v... | 11/01/2011 |
| 8043611 | Regulated nucleic acid expression system The present invention provides nucleic acid constructs, expression systems, and methods relating to the regulation of gene expression. The invention may be applied to regulate the expression of any coding sequence of interest, including those coding for viral compon... | 10/25/2011 |
| 8034331 | Method of delivery of nucleic acids to peripheral neurons The invention provides for methods for delivering a nucleic acid into a peripheral neuron by identifying a target neuron in a dorsal root ganglion and intrathecally delivering a vector comprising the nucleic acid to the dorsal root ganglion neuron. The nucleic acid ... | 10/11/2011 |
| 8034330 | Modified organs and cells for xenotransplantation It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an α-galac... | 10/11/2011 |
| 8029778 | Methods of using TICAM-1, an adapter protein that binds toll-like receptor 3 A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is effective for prevention/treatment of viral infectious disease such as hepat... | 10/04/2011 |
| 8029777 | system and uses thereof Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells tha... | 10/04/2011 |
| 8021653 | Shuttle vector for and The present invention provides a shuttle vector for a microorganism of the genus Bifidobacterium (BM) and Escherichia coli having a wide host range and a large copy number in BM and capable of highly expressing a desired protein when used as an express... | 09/20/2011 |
| 8012467 | Multivalent vaccines comprising recombinant viral vectors The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. The invention also relates to the us... | 09/06/2011 |
| 8007780 | AAV vectors for gene delivery to the lung Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which display tropism for lung tissue. ... | 08/30/2011 |
| 7998472 | CD34 stem cell-related methods and compositions This invention provides novel stem cell-based methods for treating a number of conditions. These methods employ CD34− stem cells, and have a tremendous advantage in that they do not require myeloablation in the subject being treated. The CD34− | 08/16/2011 |
| 7998473 | Methods of treatment or prevention of gastrointestinal disorders using canine probiotic bifidobacterium According to the invention there is provided a strain of lactic acid bacteria of the species Bifidobacteria pseudolongum obtainable by isolation from resected and washed canine gastrointestinal tract having a probiotic activity in animals. Methods of use and ... | 08/16/2011 |
| 7998471 | Mycobacteria expressing HIV-1 and malaria antigens Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and... | 08/16/2011 |
| 7989426 | Selective induction of apoptosis to treat ocular disease by expression of PEDF The invention is directed to a method of prophylactically or therapeutically treating choroidal neovascularization, wherein the method comprises directly administering to the eye a therapeutic factor or a nucleic acid sequence that encodes a therapeutic factor, whic... | 08/02/2011 |
| 7972593 | Delivery of therapeutic agents to the bone This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinat... | 07/05/2011 |
| 7968086 | Genetically stable enterovirus expression vector with replaced stem loop VI The present invention relates, in general, to an expression vector and in particular, to a genetically stable viral expression vector. ... | 06/28/2011 |
| 7964185 | Apicomplex vaccine strains of a family of Sarcocystidae The invention relates to attenuate mutated strains of apicomplex of a family of Sarcocystidae, containing inactivated MIC1 and MIC3 adhesins and to the use thereof for a vaccine. ... | 06/21/2011 |
| 7955595 | Glutamic acid decarboxylase (GAD) based delivery system The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions us... | 06/07/2011 |
| 7947268 | based oral vaccines for anthrax A vaccine for the prevention of anthrax, including a live, attenuated Salmonella and at least one nucleotide sequence encoding anthrax protective antigen (PA) or a fragment thereof and a nonlethal mutated form of anthrax lethal factor (LF) or a fragment there... | 05/24/2011 |
| 7943125 | Attenuated gram negative bacteria Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99... | 05/17/2011 |
| 7935333 | Method and compositions for modifying target receptor function associated with neurological disorders A method of treating or preventing development of a neurological disorder has been developed wherein a subject with the disorder, or at risk of developing a disorder, is vaccinated against a brain protein or antigen. Alternatively, the antibodies can be directly adm... | 05/03/2011 |
| 7927585 | Production of recombinant AAV virions Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokar... | 04/19/2011 |
| 7927586 | Vaccine for porcine post-weaning diarrhea caused by enterotoxigenic Vaccines and methods for making and using the same. An example vaccine may be a vaccine against enterotoxigenic Escherichia coli. The vaccine may include an Escherichia coli strain. The Escherichia coli strain may produce K88 fimbria and a fusio... | 04/19/2011 |
| 7919478 | Method for treating diabetic ulcers with vectors encoding VEGF A method and means have been developed to deliver a therapeutic dose or dosages of the angiogenic molecule, Vascular Endothelial Growth Factor (VEGF) that results in a statically significant decrease in the time to achieve 100% wound closure and accelerates the rate... | 04/05/2011 |
| 7910093 | Method for detecting cancer cells and monitoring cancer therapy Disclosed herein are methods for identifying cancer cells and monitoring anti-cancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice growing subcutaneously, intrape... | 03/22/2011 |
| 7906111 | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogeni... | 03/15/2011 |
| 7901671 | Therapeutic retroviral vectors for gene therapy The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. The invention further provides improved gene therap... | 03/08/2011 |
| 7883696 | Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type... | 02/08/2011 |
