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| Number | Title | Issue Date |
| 8187585 | Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide The present invention relates to a composition comprising at least one fibronectin binding protein, and/or at least one a truncated fibronectin binding protein and/or at least one fibronectin binding peptide, all comprising at least one fibronectin binding domain; a... | 05/29/2012 |
| 8183218 | Agent for inducing apoptosis comprising MSX1 or a gene encoding the same as an active ingredient The present invention relates to a novel use of Msx1 protein or a nucleotide encoding the same for inducing apoptosis. The Msx1 of the present invention induces apoptosis through direct interaction with p53 via a homeodomain and such interaction leads to increased s... | 05/22/2012 |
| 8178504 | Gene therapy expression of GHRH for increasing RBC count in subjects The present invention pertains to compositions and methods useful for treating anemia and other effects that are commonly associated in cancer bearing animals. The invention is accomplished by delivering an effective amount of a nucleic acid expression construct tha... | 05/15/2012 |
| 8178084 | Pharmaceutical kits comprising mesenchymal stem cells A method of treating a natural soft skeletal tissue injury in a patient the method comprising administering to the patient a composition of mesenchymal stem cells in liquid suspension enriched compared to the natural source of said cells, or tenocytes derived theref... | 05/15/2012 |
| 8178087 | Process of production of bacteriophage compositions and methods in phage therapy field A method for producing bacteriophage stock compositions including (a) incubating a culture medium including at least one bacterial strain, at least one bacteriophage strain that can infect the bacterial strain, and at least one antibiotic, wherein the concentration ... | 05/15/2012 |
| 8178086 | Activation of HCV specific T cells Methods for activating HCV-specific T cells are described. The methods utilize one or more administrations of HCV protein compositions, followed by one or more administrations of a viral vector comprising a nucleic acid encoding a least one HCV epitope that is prese... | 05/15/2012 |
| 8178085 | Methods of proliferating stem cells The invention relates to methods of proliferating stem cells. More particularly, the invention relates to the use of glycosaminoglycans or proteoglycans to promote the growth of stem cells in ex vivo culture, while preserving their multipotentiality. ... | 05/15/2012 |
| 8168167 | Method for biologically combating the proliferation of , and novel disinfecting agent containing amoebic protozoa of the genus The invention relates to a method for biologically combating the proliferation of Legionella pneumophila, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses amoebic protozoa of the species Willaer... | 05/01/2012 |
| 8168166 | Live genetically attenuated malaria vaccine Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function. ... | 05/01/2012 |
| 8163275 | Multi-lineage progenitor cells Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described. ... | 04/24/2012 |
| 8158119 | Cardiac targeted delivery of cells A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit. | 04/17/2012 |
| 8158596 | Materials and methods for FOXP3 tumor suppression Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor... | 04/17/2012 |
| 8158121 | Cardiac muscle regeneration using mesenchymal stem cells Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix whic... | 04/17/2012 |
| 8158120 | Cardiac muscle repair or regeneration using bone marrow-derived stem cells Disclosed are compositions and methods for repairing and/or regenerating cardiac tissue by administering adult bone marrow-derived stem cells to an individual. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is o... | 04/17/2012 |
| 8158118 | Mesenchymal precursor cell A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differen... | 04/17/2012 |
| 8142769 | Preparation and xenotransplantation of porcine islets The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient m... | 03/27/2012 |
| 8137662 | Proliferated cell lines and uses thereof The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and ... | 03/20/2012 |
| 8137663 | Oncolytic virus therapy A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acce... | 03/20/2012 |
| 8128921 | Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when present in naturally occurring form, encodes a protein necessary for... | 03/06/2012 |
| 8124592 | Development of a preventive vaccine for filovirus infection in primates The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus. ... | 02/28/2012 |
| 8124067 | Method for immunotherapy of tumors A method for making dendritic cells reactive to an antigen comprises obtaining a sample of dendritic cells and contacting the cells with the antigen and at least one Toll-like receptor stimulant. Dendritic cells activated by this method provide a means for treating ... | 02/28/2012 |
| 8124068 | Recombinant intracellular pathogen immunogenic compositions and methods of use Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular pathogens are provided. Exemplary immunogenic compositions include, but are n... | 02/28/2012 |
| 8101167 | Conditioned medium and uses thereof The invention relates to compositions containing an agent that has an irritant side effect and a conditioned cell culture medium and/or of an extract thereof, for use, e.g., in the treatment of signs of inflammation and/or of immune disorders, the medium being obtai... | 01/24/2012 |
| 8101168 | Attenuated FNR deficient enterobacteria The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated... | 01/24/2012 |
| 8097242 | Target CA125 peptides for cancer immunotherapy TADG-12 and CA125 are two proteins expressed with high specificity in ovarian cancer tumors. They thus would be potential antigens for immunotherapy in ovarian cancer. The invention is based on the discovery of peptides in TADG-12 and CA125 that can be used to induc... | 01/17/2012 |
| 8084023 | Maintenance and propagation of mesenchymal stem cells Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same. ... | 12/27/2011 |
| 8080240 | Parvovirus methods and compositions for killing neoplastic cells According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursers, while leaving healthy cells intact. The invention thus comprises a method of ki... | 12/20/2011 |
| 8071083 | Tissue regeneration The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded scaffold; allowing or effecting a wound healing response at the site of said defect; allowing said scaffold ... | 12/06/2011 |
| 8066982 | Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing and treating HIV An isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41 and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activi... | 11/29/2011 |
| 8066983 | Attenuated poliovirus A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of... | 11/29/2011 |
| 8062633 | Surface sanitizer for the food industry based on three new lactic acid bacteria that have antagonistic action against , the microorganism that causes listeriosis in humans The present invention relates to a formulation useful to control Listeria monocytogenes that comprises three new lactic acid bacteria, namely Carnobacterium maltaromaticum ATCC® PTA-9380, C. maltaromaticum ATCC® PTA-9381 and Enterococcus mu... | 11/22/2011 |
| 8062632 | Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof A method for making hepatocytes from extrahepatic somatic stem cells comprises: a) culturing somatic stem cells in a medium comprising hepatic growth factor to cause the stem cells to differentiate toward hepatocytes; b) culturing cells from a) in a medium comprisin... | 11/22/2011 |
| 8057788 | Placental stem cell populations The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides m... | 11/15/2011 |
| 8057789 | Placental stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells The present invention provides compositions and methods of using placental stem cells that originate from a postpartum placenta with conventional cord blood compositions or other stem or progenitor cells. The placental stem cells can be used alone or in a mixture wi... | 11/15/2011 |
| 8058253 | Growth hormone releasing hormone treatment to decrease cholesterol levels This invention is related to compositions and methods for decreasing cholesterol levels in a subject. The method utilizes a nucleic acid expression construct that encodes a growth-hormone-releasing-hormone (“GHRH”) that is delivered into a tissue of the subject,... | 11/15/2011 |
| 8048409 | Cellular therapy to heal vascular tissue The present invention encompasses methods and apparatus for minimizing the risks inherent in endovascular grafting for blood vessel therapy and repair. The invention involves delivering adult stem cells, embryonic stem cells, progenitor cells, fibroblasts, or smooth... | 11/01/2011 |
| 8043609 | Viral complement control proteins for eye disorders The present invention provides compositions and methods for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration or choroidal neovascularization, ocular inflammation, or any combination of these. Certain of ... | 10/25/2011 |
| 8043610 | Freeze-dried composition of inactivated virus envelope with membrane fusion activity The objects of the present invention are to provide a freeze-dried composition of an inactivated virus envelop having membrane fusion activity which can be stored at higher temperatures without losing the ability to introduce foreign matters and to provide a method ... | 10/25/2011 |
| 8034328 | Method for enhancing stem cell trafficking Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the animal's circulatory system. The animal may be healthy or suffering some dis... | 10/11/2011 |
| 8034791 | Activation of Egr-1 promoter by DNA damaging chemotherapeutics The present invention relates to methods of inducing expression of a polynucleotide encoding a therapeutic polypeptide, e.g., TNF-α, in a cell comprising contacting the cell with a construct comprising an Egr-1 promoter operably linked to a polynucleotide encoding ... | 10/11/2011 |
