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| Number | Title | Issue Date |
| 7988951 | Method for inducing selectively suppressed immune response to transplanted tissue or cells Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transp... | 08/02/2011 |
| 7655218 | Methods and compositions for detection and diagnosis of infectious diseases Methods and compositions for the detection and diagnosis of infectious diseases are provided. In particular, efficient and sensitive methods and compositions for the detection of active mycobacterial disease are provided for distinguishing between individuals having... | 02/02/2010 |
| 7176296 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the ... | 02/13/2007 |
| 7144569 | Diagnosis of coeliac disease using a gliadin epitope A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence fr... | 12/05/2006 |
| 7115579 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immun... | 10/03/2006 |
| 7105495 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immun... | 09/12/2006 |
| 6982090 | More easily visualized punctum plug configurations An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a substance causing at least the outwardly exposed surface to contrast... | 01/03/2006 |
| 6833128 | Method for monitoring local reaction associated with injections A method is disclosed for monitoring local reactions, such as inflammatory responses, associated with injection sites. The method is performed using a temporary tattoo, which is transferred from a substrate to the skin of a subject, to measure the local reaction to ... | 12/21/2004 |
| 6830891 | Methods for diagnosis of allergic bronchopulmonary aspergillosis Methods for the diagnosis of ABPA in a human individual comprise determining if the individual carries antibodies reactive with one or more ABPA-related recombinant allergens, which one or more ABPA-related recombinant allergens discriminate between ABPA and allergi... | 12/14/2004 |
| 6756032 | Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge The present invention relates to a method comprising subjecting a test site of a responsive system to a primary challenge; subjecting the same test site to a secondary challenge, wherein the secondary challenge is designed to enhance and/or prolong a response of the... | 06/29/2004 |
| 6558961 | Immunodiagnostics using particle delivery methods Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the individual are provided.... | 05/06/2003 |
| 6410720 | Compounds and methods for treatment and diagnosis of mycobacterial infections The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Metho... | 06/25/2002 |
| 6379909 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of ... | 04/30/2002 |
| 6340455 | Testkit and method Skin prick test for the determination of the predisposition of an individual to develop marginal periodontitis, said kit comprising: (a) a first reagent containing a known quantity of a surface structure common to anaerobic Gram negative pathogens which i... | 01/22/2002 |
| 6309845 | Method of establishing the origin of useful animals and products produced therefrom The invention concerns a method of establishing the origin of useful animals, in particular cattle, pigs and the like. This method comprises the following steps: a) the live animal is marked biologically by applying at least one antigen which is harmless ... | 10/30/2001 |
| 5965455 | Ryegrass pollen allergen The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least... | 10/12/1999 |
| 5939046 | Method of evaluating an effect of a substance applied to the skin of a mammal A method for evaluating an effect of a substance when applied to mammalian skin is provided. The method comprises the steps of: (i) assessing an immune response of the skin of at least one mammal to an antigen, to which the mammal has been sensitized, in ... | 08/17/1999 |
| 5874401 | Cedar pollen protein and use thereof in treating, preventing, and diagnosing pollenosis A protein having a molecular weight of 44,000-54,000 daltons, isoelectric point of 8.5-9.2 and specific sugar chain is prepared from a cedar pollen. The protein induces pollenosis and can be suitably used as desensitization agent because it induces immuno... | 02/23/1999 |
| 5773010 | Low molecular weight allergen obtained from Dermatophagoides farinae New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen... | 06/30/1998 |
| 5496554 | Purified mite allergen New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen... | 03/05/1996 |
| 5104620 | Disposable allergy skin testing kit A disposable allergy skin testing kit that is formed from a top layer sheet, a membrane sheet, and a bottom layer sheet. The bottom sheet has a plurality of recesses formed at predetermined locations to form chambers into which a predetermined antigen has... | 04/14/1992 |
| 5064637 | Substituted sulfonamide derivatives which inhibit allergic reactions The present invention involves intradermal, percutaneous, parenteral, or enteral administration of a newly synthesized compound to detect, reduce, or eliminate the occurrence of allergic reactions to sulfonamides. The new compound is a substituted sulfona... | 11/12/1991 |
| 4952395 | Mycobacterial recombinants and peptides Recombinant 540 amino acid residue and 517 amino acid residue proteins encoded by the genome of Mycobacterium tuberculosis are disclosed as are vectors for propagating their DNA sequences and expressing the proteins. Also disclosed are methods for using t... | 08/28/1990 |
| 4855126 | Method to detect T-antigen delayed hypersensitivity Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(ଲ-D-galactopyranosyl)--D-galactopyran oside containing an -O-glycosidically linked bridging arm O--(CH2)n ... | 08/08/1989 |
| 4752471 | Cancer detection preparations and method A method for detecting cancer comprises intradermally injecting into a patient a test preparation comprising a glycoprotein-polysaccharide-like antigenic substance admixed with the patient's blood serum. The patient's serum is also injected intradermally ... | 06/21/1988 |
| 4499065 | Chymopapain allergen and method A chymopapain derivative having the enzymatic activity reduced by at least 95% while retaining the original allergenic activity of at least 90% is suitable for skin testing to detect allergic hypersensitivity to chymopapain and for treating patients exhib... | 02/12/1985 |
| 4386062 | Intradermal horse sweat test A method for semi-quantitativly determining the ability of horses, mules, donkeys and zebras to sweat, which comprises intradermally administering a series of at least twofold dilutions of at least one pharmaceutical compound having ଲ-2 stimulator a... | 05/31/1983 |
| 4316882 | Compositions for testing to predict and/or diagnose allergy to penicillins The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new materials... | 02/23/1982 |
| 4297338 | Malignant tumor immunity level detection Disclosed is a method of detecting in a human the subject's extent of immunity to malignant tumor development, by (a) intradermally injecting into the subject an aqueous isotonic diagnostic solution of (i) a polysaccharide-like antigenic product obtained ... | 10/27/1981 |
| 4252784 | Method and composition for testing to predict and/or diagnose allergy to penicillins The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicillo... | 02/24/1981 |
| 4228147 | Composition and method for testing to predict and/or diagnose allergy to penicillins The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicillo... | 10/14/1980 |
| 4183910 | Method for testing to predict and/or diagnose allergy to penicillins, and compounds and compositions for use in such tests The invention relates to the testing of humans or other animals, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations... | 01/15/1980 |
| 4150107 | Antigen from schistosomes and process for obtaining same The invention relates to a process for obtaining antigens from living adult schistosomes, wherein schistosomes are kept alive for 12 to 96 hours in a sterile physiologically tolerable salt solution, subsequently isolated and extracted with an aqueous medi... | 04/17/1979 |
| 4031199 | Process for the production of allergen-containing extracts Improved allergen-containing extracts are obtained by the extraction of allergy-causing materials, such as pollen and house dust, with hydrophilic aqueous extractants, by pretreating the allergen-containing material with a lipophilic, aqueous extraction l... | 06/21/1977 |
| 3995023 | Process for the production of allergen-containing extracts Improved allergen-containing extracts are obtained by the extraction of allergy-causing materials, such as pollen and house dust, with hydrophilic aqueous extractants, by pretreating the allergen-containing material with a lipophilic, aqueous extraction l... | 11/30/1976 |
| 3979508 | Compositions and methods therewith for penicillin hypersensitivity detection The stereo-isomeric penicilloyl-polylysine conjugates having high optical dextro-rotations are useful for eliciting cutaneous responses in persons with penicillin hypersensitivity. The process for manufacturing the above-entitled stereo-specific conjugates ... | 09/07/1976 |
| 3969497 | Test substance for tuberculosis A new test substance for use in skin testing for tuberculosis, which substance is produced from Mycobacterium tuberculosis (M.tb.) culture filtrate or bacillary extract. The culture filtrate or extract is first fractionated by means of chromatography. Res... | 07/13/1976 |
| 3943119 | Tuberculin active proteins and peptides from the cells of tubercle bacilli Tuberculin active simple proteins and peptides which have the following peptide linkage as a tuberculin active functional group, and a process for preparing the same from the cells of tubercle bacilli.... | 03/09/1976 |
