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| Number | Title | Issue Date |
| 7704489 | Method of photocatalytic nanotagging A nanotagged chemical structure comprising a chemical structure with an associated photocatalyst and a tagging nanoparticle (a nanotag) grown in proximity to the photocatalyst, and a method for making the nanotagged chemical structure. The nanoparticle is grown in p... | 04/27/2010 |
| 7682603 | Polymersomes incorporating highly emissive probes The instant invention concerns compositions comprising polymersomes, visible or near infrared emissive agents, and optionally a targeting moiety associated with a surface of the polymersome. The invention also relates to use of these compositions in the treatment of... | 03/23/2010 |
| 7371742 | Porphyrin derivatives for photodynamic therapy This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells, bacteria, tumorous tissues. The invention also relates to compositions contai... | 05/13/2008 |
| 7348361 | Solution for diagnosing or treating tissue pathologies The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followe... | 03/25/2008 |
| 7320786 | Photodynamic therapy treatment for eye disease This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing ... | 01/22/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7297326 | Ocular diagnosis of Alzheimer's disease The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound, which binds to an amyloid protein. An increase in binding of the compound... | 11/20/2007 |
| 7268155 | Photosensitizer conjugates for pathogen targeting Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described. ... | 09/11/2007 |
| 7265100 | Separation of regioisomers of metal phthalocyanines The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as phototherapeutic and photodiagnostic agents ... | 09/04/2007 |
| 7255851 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 08/14/2007 |
| 7247655 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy... | 07/24/2007 |
| 7244841 | Porphyrin derivatives and their use in photodynamic therapy A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated... | 07/17/2007 |
| 7198774 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 04/03/2007 |
| 7192650 | Element having porphyrin polymer fixed on a substrate and method of preparing the same A photo-functional molecule element having, on a substrate, a porphyrin polymer containing covalently-fixed porphyrin units, and the method of preparing the same. The photo-functional molecule element may be used as a photoelectric conversion element such as an orga... | 03/20/2007 |
| 7190109 | Illuminator for photodynamic therapy An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible lig... | 03/13/2007 |
| 7166719 | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferativ... | 01/23/2007 |
| 7153956 | Cyanine dye having multifunctional peripheral groups The present invention provides an IR-absorbing dye of formula (I) or (II) wherein R10, R13, R20, R23, R30, R33, R40 and R | 12/26/2006 |
| 7148345 | Synthetically expedient water-dispersible IR dyes having improved lightfastness The present invention provides an IR-absorbing naphthalocyanine dye of formula (I): wherein M is selected from Ga(A1); A1 is an axial ligand selected from —OH, ha... | 12/12/2006 |
| 7147840 | Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof A compound having the structural formula: where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 132-Oxo-bacteriopyropheophorbide—a carboxylic acid a... | 12/12/2006 |
| 7138391 | Hydrophilizable and hydrophilic cyanine dyes The present invention provides an IR-absorbing dye of formula (I) or (II): wherein Q1, Q2, Q3 and Q4 are the same or different and are independently select... | 11/21/2006 |
| 7138103 | Use of bi-specific antibodies for pre-targeting diagnosis and therapy The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable construct comprises a carrier portion which comprises or bears at least... | 11/21/2006 |
| 7135193 | Liposome compositions of porphyrin photosensitizers Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin photosensitizer, particularly the hydro-mono benzoporphyrins (BPD) having ... | 11/14/2006 |
| 7125542 | Methods and compositions for treating conditions of the eye Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT me... | 10/24/2006 |
| 7122076 | Synthetically expedient water-dispersible IR dyes The present invention provides an IR-absorbing naphthalocyanine dye of formula (I): wherein M is selected from Si(A1)(A2), Ge(A1)(A2)... | 10/17/2006 |
| 7112671 | Non-symmetric tripyrranes in the synthesis of novel macrocycles The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, ... | 09/26/2006 |
| 7110808 | Method of optimizing radiosurgery and radiotherapy with metalloporphyrins An apparatus and method for subsequent optimization of radiosurgery and radiotherapy is provided. The invention includes administering a metalloporphyrin to the patient, and then creating a 3-dimensional mapping of tissue through use of PET or SPECT. Malignant and p... | 09/19/2006 |
| 7094866 | Covalently fixed porphyrin polymer having porphyrin metal complex substituted with coordinating hetero aromatic ring as constituting unit thereof,and method of producing the same A covalently linked linear porphyrin polymer represented by formula (1): wherein R represents an alkyl group or | 08/22/2006 |
| 7087214 | Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases The invention relates to novel, water-soluble porphyrin platinum compounds of the tetraarylporphyrin platinum derivatives type or of the hematoporphyrin platinum derivatives type with high tumor selectivity and their use for the treatment of benign and malignant tum... | 08/08/2006 |
| 7067276 | Method of using metaloporphyrins for treatment of arteriosclerotic lesions A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a radioactive metal. Cells which exhibit an affinity for the porphyrin e... | 06/27/2006 |
| 7053210 | Efficient synthesis of pyropheophorbide a and its derivatives A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, wit... | 05/30/2006 |
| 7045117 | Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives Palladium-substituted Bacteriochlorophyll derivatives are administered to a subject suspected of having a tumor and the patient is then irradiated and the fluorescence of the suspected area is measured. A high fluorescence indicates a tumor site. A preferred derivat... | 05/16/2006 |
| 7038041 | Selective nuclear receptor-targeted systems for delivery of cytotoxins to cancer cells for targeted photodynamic therapy An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The meth... | 05/02/2006 |
| 7030105 | Method of synthesis of β-thiolato cobalamin compounds The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH, specifically from one to less than four molar equivalents of GluSH. The... | 04/18/2006 |
| 7026347 | Porphyrin-polyamine conjugates for cancer therapy Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conju... | 04/11/2006 |
| 7022840 | Porphyrin array exhibiting large two photon absorption property and including, as structural unit, bis (imidazolylporphyrin metal complex) linked with acetylenic bond and the derivative thereof, and method of producing the same A porphyrin array exhibiting a large two-photon absorption property, and being linked with an acetylenic bond(s), represented by the following formulas: wherein R1 represents an alkyl or aryl group, M1 | 04/04/2006 |
| 7019132 | Porphyrin derivatives The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing singlet state oxygen radical and the inventive compounds have superior adva... | 03/28/2006 |
| 7015240 | Treatment of macular edema The invention relates to the use of photodynamic therapy (PDT) to treat macular edemas, including DME, CRVO and BRVO. It provides an alternative to photocoagulation and the disadvantages associated therewith. ... | 03/21/2006 |
| 7014839 | Light imaging contrast agents The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging. ... | 03/21/2006 |
| 7008742 | Heat-induced formation of co-crystalline composition containing titanyl phthalocyanine and titanyl fluorophthalocyanine A process for forming a cocrystalline mixture of titanyl phthalocyanine (TiOPc) and titanyl fluorophthalocyanine (TiOFPc) includes: dry milling a mixture of crude TiOPc and crude TiOFPc, thereby forming an amorphous pigment mixture of TiOPc and TiOFPc; and heating t... | 03/07/2006 |
| 7008937 | Porphyrins and metalloporphyrins for inhibiting heme iron uptake The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are tetra-positively charged porphyrins based on meso-tetra(4-pyridyl)porp... | 03/07/2006 |
