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| Number | Title | Issue Date |
| 8153103 | Conjugates of photo-activatable dyes A new class of photoactivatable dyes provides the ability to study cell-cell communication in live animals non-invasively with high spatiotemporal resolution. The compositions are made up of a macromolecule, a caging group, and a coumarin dye. Upon photolysis, the c... | 04/10/2012 |
| 8147806 | Cellular labeling for nuclear magnetic resonance techniques The disclosure provides, in part, fluorocarbon imaging reagents and formulations for the ex vivo labeling of cells. Labeled cells may be detected in vivo or ex vivo by a nuclear magnetic resonance technique, such as magnetic resonance imaging (MRI) or magnetic reson... | 04/03/2012 |
| 8128908 | Nanoparticles and their use for multifunctional bioimaging The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use. The invention provides for multifaceted bioimaging (e.g., intra-arter... | 03/06/2012 |
| 8092784 | Enzyme substrate comprising a functional dye and associated technology and methods Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of th... | 01/10/2012 |
| 8080235 | Protein kinase A reporters useful in high throughput assays Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds. ... | 12/20/2011 |
| 8029767 | Fluorescent membrane intercalating probes and methods for their use The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles,... | 10/04/2011 |
| 8029766 | Intravascular imaging device and uses thereof The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging age... | 10/04/2011 |
| 8021647 | In vivo optical imaging Provided herein are methods for imaging an optically labeled target cell implanted in vivo using a reporter construct that encodes an enzyme that is not endogenous to the target cell. The disclosed methods include the steps of: (a) introducing target cell transforme... | 09/20/2011 |
| 7951357 | Implantable power sources and sensors A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the... | 05/31/2011 |
| 7906106 | In vivo cell trafficking Provided herein are methods of monitoring inflammatory cell migration in a mammal. The methods include the steps of: providing a donor mammalian subject; introducing an inflammatory agent into the donor mammal to create a granuloma; isolating granuloma-derived nucle... | 03/15/2011 |
| 7897142 | Peptide based-compounds The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. ... | 03/01/2011 |
| 7875261 | Fluorinated resorufin compounds and their application The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one o... | 01/25/2011 |
| 7875260 | Imaging agents for functional imaging of lymphatic structures Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid which bind to the receptors. Lymph vascular cell receptor expression m... | 01/25/2011 |
| 7829066 | Assay for anti-metastatic agents This invention relates, e.g., to a method for identifying an agent that inhibits a metastatic cell (e.g. that inhibits cancer metastasis), comprising measuring the amount of seeding of a tumor by a detectably labeled, metastatic cell, in a subject, in the presence a... | 11/09/2010 |
| 7790144 | Receptor-avid exogenous optical contrast and therapeutic agents Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologes. The compounds are be conjugated to bioactive peptides, carbohydrates, horm... | 09/07/2010 |
| 7736624 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell an... | 06/15/2010 |
| 7736625 | Light stabilized in vivo stain composition and method of manufacture Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive ground state. ... | 06/15/2010 |
| 7727513 | Method for screening for bacterial conjunctivitis A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discov... | 06/01/2010 |
| 7682602 | Near-infrared fluorescent contrast medium A near-infrared fluorescing contrast medium which exhibits superior imaging capability and is also difficult to accumulate in a living body, is disclosed, comprising a cyanine compound containing water-solubilizing groups and represented by the following formula. Th... | 03/23/2010 |
| 7655217 | Near infrared imaging agent This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluoresc... | 02/02/2010 |
| 7625550 | Enhanced resolution of tumor metastasis using a skin flap model A enhanced method for observing tumor progression, angiogenesis and/or metastasis in animal models in real time is described. The invention employs a skin flap over the area to be observed that can be opened and closed reversibly. The invention also permits simultan... | 12/01/2009 |
| 7597878 | Optical fluorescent imaging Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a lig... | 10/06/2009 |
| 7566444 | Versatile hydrophilic dyes Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to... | 07/28/2009 |
| 7556797 | Minimally invasive physiological function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 07/07/2009 |
| 7514069 | Tumor-targeted optical contrast agents Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormo... | 04/07/2009 |
| 7510699 | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in res... | 03/31/2009 |
| 7510700 | Pathological tissue detection and treatment employing targeted benzoindole optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and pho... | 03/31/2009 |
| 7507395 | Methods of using fluorescent pH indicators for intracellular assays Systems, including compositions and methods, for measuring pH, particularly in cells, organelles, and other samples. The compositions include pH-sensitive fluorescent and fluorogenic 2′,7′-dialkylfluorescein derivatives and associated nonfluorescent precursor co... | 03/24/2009 |
| 7504089 | Cyanine dyes A compound of the formula (I) wherein the variables are defined herein. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided. ... | 03/17/2009 |
| 7488468 | Near infrared fluorescent contrast agent and fluorescence imaging A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living ... | 02/10/2009 |
| 7481994 | Calcium biosensor polypeptides and methods of use The invention features methods and compositions for determining states of intracellular calcium stores in a eukaryotic cell. Also provided are methods for identifying an agent (e.g., a gene product or small molecule compound) that modulates intracellular calcium sto... | 01/27/2009 |
| 7473415 | Near infrared fluorescent contrast agent and method for fluorescence imaging A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R... | 01/06/2009 |
| 7470420 | Optical determination of glucose utilizing boronic acid adducts The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particu... | 12/30/2008 |
| 7462346 | Light-stabilized(in vivo) stain composition and method of manufacture Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive ground state. ... | 12/09/2008 |
| 7462347 | Fluorescent membrane intercalating probes The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles,... | 12/09/2008 |
| 7445767 | In-vivo diagnostic method by near infrared radiation This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluoresc... | 11/04/2008 |
| 7438894 | Dyes for organ function monitoring Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 10/21/2008 |
| 7431925 | Internal image antibodies for optical imaging and therapy Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molec... | 10/07/2008 |
| 7408095 | Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen Methods of introducing heterologous cells into fish are provided. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are also use... | 08/05/2008 |
| 7403812 | Method and apparatus for determining target depth, brightness and size within a body region A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originat... | 07/22/2008 |
