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| Number | Title | Issue Date |
| 7862800 | Radiopaque cyanoacrylate compositions This invention relates to sterilized cyanoacrylate adhesive compositions with x-ray imagining capabilities, methods of making such compositions, and methods of using such compositions. ... | 01/04/2011 |
| 7255877 | Fenofibrate microparticles Fenofibrate microparticles are prepared using a combination of surface modifiers with a phospholipid. Particle size growth and stability are controlled while significantly smaller sized fenofibrate particles are produced. ... | 08/14/2007 |
| 7198795 | methods for evaluating the effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions. ... | 04/03/2007 |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7112340 | Compositions of and method for preparing stable particles in a frozen aqueous matrix The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The ... | 09/26/2006 |
| 7037528 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 05/02/2006 |
| 6977085 | Method for preparing submicron suspensions with polymorph control The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) d... | 12/20/2005 |
| 6962689 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver. ... | 11/08/2005 |
| 6951656 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 10/04/2005 |
| 6531111 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.... | 03/11/2003 |
| 6475466 | Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of en... | 11/05/2002 |
| 6203779 | Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of en... | 03/20/2001 |
| 6072069 | Biodegradable nonionic contrast media Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being triiodo-3,5-diaminobenzoic acid derivatives, where the functional groups are der... | 06/06/2000 |
| 6051210 | N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R1, R2, R3, R4, R5, R6, R7 and R8 are th... | 04/18/2000 |
| 5725840 | Steroidal ester contrast media for x-ray and magnetic resonance imaging The present invention relates to metabolically labile esters, and to contrast media for X-ray and magnetic resonance imaging comprising these esters. The esters have formula (I): ##STR1## in which R3 is asteroid residue. The esters contain... | 03/10/1998 |
| 5695742 | Aqueous injectable formulations useful for radiodiagnosis comprising iodinated aromatic compounds used as X-ray contrast media This invention refers to injectable aqueous formulations containing radiopaque contrast agents useful for X-ray imaging of human or animal body. This invention specially deals with injectable aqueous solutions of mixtures of non-ionic and water-soluble io... | 12/09/1997 |
| 5693311 | Polyiodinated compounds, process for preparing them and diagnostic compositions A compound of the following formula II ##STR1## in which R7, R8, R'7, R'8, collectively, contain 10-24 hydroxyl groups and are selected, independently, from H, (C1 -C10)alkyl, (C1... | 12/02/1997 |
| 5670136 | 2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and R... | 09/23/1997 |
| 5587143 | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene ... | 12/24/1996 |
| 5575905 | Iodination process The invention provides a process for the preparation of a 2,4,6-triiodinated or 2,4,6,2',4',6'-hexaiodinated 3,5-disubstituted-aniline or 3,3'-disubstituted-5,5'-linked bisaniline, which process comprises electrochemically iodinating a 3,5-disubstitu... | 11/19/1996 |
| 5550263 | X-ray contrast agent The present invention refers to a phospholipid-based compound, that is a phospholipid to which an X-ray contrast-giving moiety has been covalently linked, liposomes comprising said compound as well as the use of said liposomes as a diagnostic or contrast ... | 08/27/1996 |
| 5531979 | Compositions of iodophenoxy alkanes and iodophenyl ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharm... | 07/02/1996 |
| 5451393 | X-ray contrast compositions useful in medical imaging An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average part... | 09/19/1995 |
| 5447710 | Method of making nanoparticulate X-ray blood pool contrast agents using high molecular weight nonionic surfactants The present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier asso... | 09/05/1995 |
| 5370861 | Iodinated esters contrast medium and use Water insoluble iodinated esters of formula (I), in which R1 is a substituted or unsubstituted C1-20 aliphatic, C7-20 araliphatic or C6-20 aryl group or a C1-20 heterocyclic group having one or more h... | 12/06/1994 |
| 5366722 | Contrast media comprising a non-ionic contrast agent and sodium ions The invention relates to improved contrast media containing non-ionic contrast agents, e.g. non-ionic iodinated X-ray contrast agents, the improvement being achieved by incorporation of sodium at 20-60 mM/l.... | 11/22/1994 |
| 5326552 | Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier asso... | 07/05/1994 |
| 5312615 | Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous solution of an iodinated opacifying agent. The ratio between th... | 05/17/1994 |
| 5312616 | Compositions of iodobenzoic acid derivatives in film-forming materials for visualization of the gastrointestinal tract Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1##... | 05/17/1994 |
| 5258172 | Iodinated aliphatic emulsions for X-ray contrast Contrast agents comprising stable aqueous emulsions of iophendylate and their use in radiological examination of the small and large intestine after oral administration are described.... | 11/02/1993 |
| 5242683 | Contrast media comprising a paramagnetic agent and an iodinated agent for X-ray and MRI There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent. The contrast medium can be used for both X-ray and magnetic resonance ... | 09/07/1993 |
| 5238714 | Efficient microcapsule preparation and method of use The present invention relates to a method of preparing microcapsules suitable for encapsulation of therapeutic and diagnostic agents. The capsular coats are prepared from biodegradable polymers. In a particular aspect of the invention, surface charge of t... | 08/24/1993 |
| 5186922 | Use of biodegradable microspheres labeled with imaging energy constrast materials The invention relates to an inexpensive and easy to use method of visualizing an arterial circulation, using biodegradable microspheres which are permeated with an imaging energy absorbent contrast material, such as an X-ray absorbent material, which enab... | 02/16/1993 |
| 4925649 | Radioiodinated diacylglycerol analogues and methods of use Novel iodinated and radioiodinated 1,2-diacylglycerol analogues are biological reagents for studying the effect of diacylglycerols in the activation of protein kinase C. This calcium-requiring enzyme may be involved in tumor promotion by phorbol diesters ... | 05/15/1990 |
| 4863714 | Sterilization of compositions of limited stability Methods and compositions are provided for producing sterile drug formulations, where drugs are thermolabile and pH sensitive. The method provides formulating the drug with a physiologically acceptable inorganic or organic acidic buffer for buffering at a ... | 09/05/1989 |
| 4735795 | Alkylammonium complexes of diatrizoic acid as X-ray contrast agents New X-ray contrast agents are provided which are alkylammonium complexes of diatrizoic acid having the structure ##STR1## X-ray contrast medium containing the above X-ray contrast agent and a carrier therefor such as a liposome carrier, and a method ... | 04/05/1988 |
| 4656224 | Radiopaque thermoset polymer Compositions consisting essentially of thermoset polymers prepared by copolymerizing a solution of an iodine containing, crosslinkable, unsaturated polyester resin dissolved in a vinyl monomer are disclosed. These compositions have been found to be useful... | 04/07/1987 |
| 4474747 | Process for increasing the tolerance of X-ray contrast media, and contrast media obtained thereby X-ray contrast media, for which the human body has a greater tolerance than that of contrast media comprising solely iodobenzene compounds, and an opacity of the same order of magnitude as the latter contrast media, comprise mixtures of benzene compounds ... | 10/02/1984 |
| 4328202 | Ionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives Ionic compounds of the formula ##STR1## wherein X is --CONR1 R2, --CH2 NH.multidot.Acyl or --CH2 OH; Y is --NR3 R4, --NH.multidot.Acyl or OR5 ; R1, R2,... | 05/04/1982 |
| 4285928 | Contrast composition for angiography A contrast composition for angiography comprising an emulsion containing an organic iodine compound as X-ray contrast agents and a perfluorocarbon compound having oxygen carrying ability.... | 08/25/1981 |
