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| Number | Title | Issue Date |
| 8147805 | Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues ... | 04/03/2012 |
| 8084018 | Methods for imaging dopamine transporter level Presented is a method for assessing dopamine transporter levels in a selected area of a subject's central nervous system by SPECT imaging comprising administering an injection of a labeled dopamine transporter ligand at approximately the time the subject is position... | 12/27/2011 |
| 7507394 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. ... | 03/24/2009 |
| 7427389 | Diagnostic agents for positron emission imaging using radiolabeled halogenated xanthenes New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene deri... | 09/23/2008 |
| 7402299 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 07/22/2008 |
| 7384623 | High energy phototherapeutic agents High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using ... | 06/10/2008 |
| 7378081 | Composition and method for direct visualization of the human appendix A positive contrast agent composition containing meglumine diatrizoate, sodium diatrizoate, simethicone, famotidine and aspartame in predetermined amounts that is orally administered to a patient for clinical evaluations of appendicitis wherein a positive contrast e... | 05/27/2008 |
| 7368101 | Process for the preparation of iopamidol and the new intermediates therein A process for the preparation of (S)-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarbox... | 05/06/2008 |
| 7338652 | Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene deri... | 03/04/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7259100 | Nanoparticles and method for making the same A method for making nanoparticles, nanoparticle inks and device layers therefrom is disclosed. In accordance with the present invention, nanoparticles are isolated from a composite material that is formed by treating a metal oxide precursor to form the metal nanopar... | 08/21/2007 |
| 7259101 | Nanoparticles and method for making the same A method for making nanoparticles, nanoparticle inks and device layers therefrom is disclosed. In accordance with the present invention, nanoparticles are isolated from a composite material that is formed by treating a metal oxide precursor to form the metal nanopar... | 08/21/2007 |
| 7198795 | methods for evaluating the effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions. ... | 04/03/2007 |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7189383 | Radioactively labelled amino acid analogues, their preparation and use The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C1–C6) alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substit... | 03/13/2007 |
| 7175828 | Modulators of β-amyloid peptide aggregation comprising D-amino acids Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3–5 D-amino ac... | 02/13/2007 |
| 7112340 | Compositions of and method for preparing stable particles in a frozen aqueous matrix The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The ... | 09/26/2006 |
| 7105151 | Oxygen delivery agents and uses for the same The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery ag... | 09/12/2006 |
| 7087212 | Multicomponent assemblies having enhanced binding properties for diagnosis and therapy An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regul... | 08/08/2006 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 7078276 | Nanoparticles and method for making the same A method for making nanoparticles, nanoparticle inks and device layers therefrom is disclosed. In accordance with the present invention, nanoparticles are isolated from a composite material that is formed by treating a metal oxide precursor to form the metal nanopar... | 07/18/2006 |
| 7078015 | Ultrasound imaging and treatment Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic dr... | 07/18/2006 |
| 7037528 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 05/02/2006 |
| 7011677 | Methods for vascular reconstruction of diseased arteries Disclosed are methods for vascular reconstruction of diseased, non-aneurysmal arteries. ... | 03/14/2006 |
| 7008614 | Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component: R1—CO2—R2 wherein R1 represents a substituted or unsubstituted 2,3,5-tri... | 03/07/2006 |
| 6998107 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 02/14/2006 |
| 6977085 | Method for preparing submicron suspensions with polymorph control The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) d... | 12/20/2005 |
| 6974593 | Insoluble drug delivery Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercriti... | 12/13/2005 |
| 6962689 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver. ... | 11/08/2005 |
| 6951641 | Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to exist in an aggregated state that is greater in increased concentrations... | 10/04/2005 |
| 6951656 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 10/04/2005 |
| 6710179 | Compounds with analgesic effect Compounds of general formula (I) wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprisi... | 03/23/2004 |
| 6660248 | Fullerene (C60)-based X-ray contrast agent for diagnostic imaging An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamid... | 12/09/2003 |
| 6599448 | Radio-opaque polymeric compositions The present invention provides a radio-opaque composition including a polymer or monomer, wherein the polymer or monomer has a non-leachable radio-opaque moiety. The non-leachable radio-opaque moiety is covalently attached to the polymer or monomer.... | 07/29/2003 |
| 6531111 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.... | 03/11/2003 |
| 6509406 | Plastic molding materials which can be detected by X-ray contrast The invention provides X-ray contrastable plastics materials with low-molecular weight iodine compounds, a process for preparing X-ray contrastable plastics materials with low molecular weight iodine compounds, the use of low molecular weight iodine compo... | 01/21/2003 |
| 6479033 | Antitumor cystostatic and contrast agent The invention concerns a composition for the treatment of tumors, of (i) at least one cytostatic drug component which is unencapsulated or is encapsulated in a PEG-, immuno-, or immuno/PEG liposome, (ii) at least one of lyophilized starch particles, degra... | 11/12/2002 |
| 6475466 | Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of en... | 11/05/2002 |
| 6426145 | Radiopaque compositions for visualization of medical devices A radiopaque polymeric composition useful as a polymer coating on a substrate. The compositions are designed to be bioabsorbable and are particularly useful on implantable medical devices, such as vascular prostheses and the like.... | 07/30/2002 |
| 6264916 | N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for x-ray CT imaging Compounds having formulae I, II or/III, or pharmaceutically acceptable salts thereof, ##STR1## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted c... | 07/24/2001 |
