Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 7947256 | Biocompatible fluorescent imaging agents This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents. ... | 05/24/2011 |
| 7399461 | Prostate-specific membrane antigen and uses thereof This invention provides a method of administering methotrexate triglutamate (MTXglu3), an inhibitor of the neurocarboxypeptidase activity of prostate specific membrane antigen, to a subject so as to inhibit release of glutamate by N-acetylaspartylglutamic acid (NAAG... | 07/15/2008 |
| 7388024 | Indeno[2,1A]indenes and isoindolo[2,1-A]indoles The present invention provides indeno[2,1a]indene and isoindolo[2,1-a]indole derivatives of the Formula I, its salts and its stereoisomers, wherein X, R1, R2, R3, R4, R6, R7, R8, R9 | 06/17/2008 |
| 7338652 | Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene deri... | 03/04/2008 |
| 7198795 | methods for evaluating the effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions. ... | 04/03/2007 |
| 7189383 | Radioactively labelled amino acid analogues, their preparation and use The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C1–C6) alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substit... | 03/13/2007 |
| 7163935 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 01/16/2007 |
| 7081452 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 07/25/2006 |
| 7078013 | Pretargeting methods and compounds Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are... | 07/18/2006 |
| 7030109 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position The present invention discloses radioligands of 9-arylsulfone of the formula (X) or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders. | 04/18/2006 |
| 7005517 | Paramagnetic metal-phthalocyanine complex compounds and contrast agent using the same The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance Imaging), diagnostic X-ray imaging and computed tomography(CT). Th... | 02/28/2006 |
| 6932961 | Oxazinocarbazoles for the treatment of CNS diseases The present invention provides isotopically labeled oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula (I) wherein R1, R2, R3 and R4 ... | 08/23/2005 |
| 6844438 | N-substituted derivatives of morphinan and uses thereof The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can... | 01/18/2005 |
| 6723746 | Functional radiographic imaging methods and agents Systems and methods for radiographic imaging of tissue using a radio-opaque imaging agent that in one embodiment accumulates intracellularly in tissue in proportion to its functional, or physiological, activity. In one embodiment, the imaging agent is a cell membran... | 04/20/2004 |
| 6710179 | Compounds with analgesic effect Compounds of general formula (I) wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprisi... | 03/23/2004 |
| 6686458 | Synthetic molecules that specifically react with target sequences The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenic... | 02/03/2004 |
| 6649142 | Labeled compounds for measuring the function of the muscarinic acetylcholine nervous system A muscarinic acetylcholine nervous system labeled compound for positron emission tomography measurement of the present invention has a structure represented by undermentioned general formula (I): ##STR1## [in the formula, W represents one selected from th... | 11/18/2003 |
| 6610850 | Contrast media for angiography The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also di... | 08/26/2003 |
| 6586592 | Bis-arylsulfones The present invention provides pharmaceutically active compounds useful for the treatment of diseases or disorders of the central nervous system.... | 07/01/2003 |
| 6509003 | Reagents for the determination of cerebral regional acetylcholinesterase activity The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); ##STR1## wherein R1 represents optionally fluorinated lower alkyl; R2 represents lower alkyl; and R3 represents alke... | 01/21/2003 |
| 6359111 | Opioid receptor targeting A compound comprising a ligand portion which has binding affinity for an opioid receptor, and a therapeutically or diagnostically effective group selected from radionuclide chelating agents, fluorochromes, toxins, drugs, polyboron moieties, proteins, biol... | 03/19/2002 |
| 6203778 | Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization The properties of a tissue extracellular space, particularly the microvascular component of that space can be characterized by the use of x-ray diagnostic modalities in conjunction with particulate contrast agents. The present invention provides a method ... | 03/20/2001 |
| 5869024 | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present metho... | 02/09/1999 |
| 5824288 | Thio-substituted pyridines as MRI ligand precursors Novel precursors of ligands or use in MRI contrast agents and which have the formula ##STR1## wherein R2-R.sub.10 are defined herein.... | 10/20/1998 |
| 5817873 | Polyiodinated compounds, their preparation and their use as contrast media for radiology The present invention relates to polyiodinated compounds with a single molecular weight having a molecular concentration of iodine of greater than approximately 20% by weight, and in particular greater than approximately 30% by weight, containing at least... | 10/06/1998 |
| 5709845 | Tricyclic functional dyes for contrast enhancement in optical imaging This invention provides functional dyes of the general formula: ##STR1## wherein R1, R2, and R5 may be the same or different and are selected from the group consisting of hydrogen, C1 -C10 alkyl, ... | 01/20/1998 |
| 5679322 | Iodinated borane cage molecules as X-ray contrast media Highly iodinated borane and carborane cage molecules, having from 60% to 90% w/w iodine, are disclosed as new and useful X-ray contrast media when combined with a pharmaceutically acceptable carrier. The inclusion of appropriate functional group substitue... | 10/21/1997 |
| 5672333 | Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging This invention provides functional dyes of the general formula: ##STR1## wherein R1, R2, and R5 may be the same or different and are selected from the group consisting of hydrogen, C1 -C10 alkyl, C1 -C... | 09/30/1997 |
| 5672332 | Delta 1,2 bicyclo4,4,0! functional dyes for contrast enhancement in optical imaging This invention provides functional dyes of the general formula: ##STR1## wherein R1, R2, and R5 may be the same or different and are selected from the group consisting of hydrogen, C1 -C10 allkyl, ... | 09/30/1997 |
| 5668196 | 3-amido-triiodophenyl esters as x-ray contrast agents This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 0 t... | 09/16/1997 |
| 5665330 | Dual purposed diagnostic/therapeutic agent having a tri-iodinated benzoyl group linked to a coumarin The invention provides a novel compound having the structure ##STR1## wherein R is alkyl and R1, R2, R3 and R4 are each independently OCH3, H or I and n is 0 or 1 and m is 0 or 1. The compound is useful in a method of treating mammals either therapeu... | 09/09/1997 |
| 5527926 | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present metho... | 06/18/1996 |
| 5488133 | Iodinated aroyloxy ketones Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1, R2, R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, ary... | 01/30/1996 |
| 5456900 | Low density microspheres and their use as contrast agents for computed tomography Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography. In one embodiment, the low density microspheres are gas-fil... | 10/10/1995 |
| 5443814 | X-ray contrast compositions containing iodophenoxyalkanes and cellulose derivatives Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for the... | 08/22/1995 |
| 5424056 | X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodoaniline derivative as the x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically accep... | 06/13/1995 |
| 5401489 | Biomodulators as universal imaging agents Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to... | 03/28/1995 |
| 5385720 | Compositions of iodobenzoic acid derivatives and cellulose derivatives for visualization of the gastrointestinal tract Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein Z is H, halo, C1 -... | 01/31/1995 |
| 5385722 | Compositions of iodophenyl esters and iodophenyl sulfonates and cellulose derivatives for visualization of the gastrointestinal tract Disclosed are contrast agents of the formula ##STR1## wherein ##STR2## Z is H, halo, C5 -C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-a... | 01/31/1995 |
| 5385721 | Compositions of alkylbenzenes and cellulose derivatives for visualization of the gastrointestinal tract Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein R is methyl, ethyl, n-propyl,... | 01/31/1995 |
