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| Number | Title | Issue Date |
| 7388024 | Indeno[2,1A]indenes and isoindolo[2,1-A]indoles The present invention provides indeno[2,1a]indene and isoindolo[2,1-a]indole derivatives of the Formula I, its salts and its stereoisomers, wherein X, R1, R2, R3, R4, R6, R7, R8, R9 | 06/17/2008 |
| 7211241 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging. ... | 05/01/2007 |
| 7201940 | Method and apparatus for thermal spray processing of medical devices The invention relates to devices for the treatment of heart disease and particularly to endo-arterial prostheses, which are commonly called stents. More particularly, the invention relates to methods of manufacturing and coating stents utilizing thermal spray proces... | 04/10/2007 |
| 7163935 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 01/16/2007 |
| 7138106 | Compositions for use in embolizing blood vessels Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylacetate, cellu... | 11/21/2006 |
| 7122172 | Methods and compositions for targeted drug delivery Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET or SPECT, and create a biological effect and methods of their use. These DDMs are variously designed to target specific receptors, then become internalized and then func... | 10/17/2006 |
| 7081452 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 07/25/2006 |
| 7060248 | Matrix metalloproteinase inhibitors Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties; a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety i... | 06/13/2006 |
| 6999078 | Method of forming a perspective rendering from a voxel space A method for forming a high spatial resolution perspective rendering from a low spatial resolution voxel space is disclosed. The method comprises steps of: a) initializing a virtual window of predetermined resolution pixels, and placing the virtual window in or near... | 02/14/2006 |
| 6974567 | Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, coronary artery disease, renal disease, thrombosis, transient isc... | 12/13/2005 |
| 6970734 | Flexible marker bands A catheter assembly comprises a catheter shaft having a first region and a second region. The first region is less radiopaque than the second region. The first region is constructed of a shaft material and the second region is constructed from the shaft material in ... | 11/29/2005 |
| 6827926 | Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy Metallotetrapyrrolic compounds having photherapeutic properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the central pyrrolic core. Also disclosed are methods of using metallotetr... | 12/07/2004 |
| 6797257 | Paramagnetic polymerized protein microspheres and methods of preparation thereof The present invention relates to a composition that includes gadolinium particles encapsulated in microsphere shells. The composition is suitable for use as a contrast agent with a plurality of imaging modalities, including, for example, ultrasound, magnetic resonan... | 09/28/2004 |
| 6689752 | Modulators of ଲ-amyloid peptide aggregation comprising D-amino acids Compounds that modulate natural ଲ amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a ଲ amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide compr... | 02/10/2004 |
| 6686458 | Synthetic molecules that specifically react with target sequences The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenic... | 02/03/2004 |
| 6676928 | Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use Perfluoroalkyl-containing complexes with polar radicals of general formula I in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex, and Z represents a linker group, are suitable for intravenous lymphography... | 01/13/2004 |
| 6660248 | Fullerene (C60)-based X-ray contrast agent for diagnostic imaging An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamid... | 12/09/2003 |
| 6596259 | Metal based cubane structure contained in an octanuclear complex stable over several oxidation states and a method of producing the same The present invention is directed to a complex comprising a redox-active metal cluster in a chemically inert shell. The inventive complex has the formula M8 (μ4 -E)4 (μ-L)12 X, where M is chosen from a transit... | 07/22/2003 |
| 6476070 | Compositions useful for remodeling body spaces A composition comprising of a monomer component comprised of at least one alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed from an alkyl cyanoacrylate monomer, an alkyl esterified f... | 11/05/2002 |
| 6476069 | Compositions for creating embolic agents and uses thereof A composition useful as an embolic agent that selectively creates an embolic blockage in the lumen of a blood vessel, duct, fistula or other like body passageways by combining a monomer component and a second component wherein, said monomer component comp... | 11/05/2002 |
| 6468502 | Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nucl... | 10/22/2002 |
| 6461587 | Perfluoroalkylamides, their production and their use in diagnosis The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.... | 10/08/2002 |
| 6447749 | Perfluoro-alkyl containing dye molecules and galencial formulations This invention describes galenical formulations that contain perfluoroalkyl-containing dye molecules and other perfluoroalkyl-containing substances. The new formulations are suitable as, i.a., contrast media for near-infrared diagnosis.... | 09/10/2002 |
| 6426059 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polmer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.... | 07/30/2002 |
| 6413495 | X-ray intercepting metal complexes of chlorin derivatives An X-ray-intercepting gold complex of mono-L-aspartyl (or mono-L-glutamyl) chlorin e6 or a salt thereof is used in the therapy of the tumor, cancer or arteriosclerosis lesions by X-ray irradiation. The complex provides a sharp x-ray image of tumor, solid ... | 07/02/2002 |
| 6383470 | Microparticle preparations made of biodegradable copolymers The invention relates to microparticle preparations made of biodegradable copolymers for use in treatment and diagnosis, especially ultrasonic diagnosis, as well as a process for their production.... | 05/07/2002 |
| 6355275 | Embolization using carbon coated microparticles Described are methods of embolization using an embolizing agent composition that includes microparticles with carbon surfaces, and comprising a contrast agent. Preferred microparticles include a permanently radiopaque particle substrate and a pyrolytic ca... | 03/12/2002 |
| 6342202 | Compositions for use in embolizing blood vessels Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylace... | 01/29/2002 |
| 6335384 | Methods for embolizing blood vessels Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer ... | 01/01/2002 |
| 6333110 | Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging Provided is a method of fluorescence imaging of living tissue using functionalized nanocrystals. The method comprises contacting an effective amount of functionalized nanocrystals with the living tissue; exposing the tissue to a spectrum of light suitable... | 12/25/2001 |
| 6319607 | Purification of functionalized fluorescent nanocrystals Provided are methods for purifying functionalized fluorescent nanocrystals having affinity ligand operably bound thereto by using a solid support matrix in a reactor through which solutions are circulated, and by using an immobilized solid phase formed by... | 11/20/2001 |
| 6309701 | Fluorescent nanocrystal-labeled microspheres for fluorescence analyses Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals operably bound to a polymeric microsphere, and a method of producing the fluorescent microspheres which comprises contacting the polymeric microsphere with a plura... | 10/30/2001 |
| 6287538 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1, R2, R3 a... | 09/11/2001 |
| 6281263 | Methods for embolizing blood vessels Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer ... | 08/28/2001 |
| 6274121 | Superparamagnetic particles, process for their manufacture and use Superparamagnetic particles consist of superparamagnetic one-domain particles and aggregates of superparamagnetic one-domain particles to whose surfaces are bound inorganic and optionally organic substances optionally having further binding sites for coup... | 08/14/2001 |
| 6261535 | Diagnostic methods for targeting the vasculature of solid tumors The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are target... | 07/17/2001 |
| 6203778 | Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization The properties of a tissue extracellular space, particularly the microvascular component of that space can be characterized by the use of x-ray diagnostic modalities in conjunction with particulate contrast agents. The present invention provides a method ... | 03/20/2001 |
| 6187285 | Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging Chelates of the compounds of formula I ##STR1## in which R is a hydrophilic group containing 3 or 4 successive phenyl rings and m is 1 or 2, with metal ions, for use in diagnostic imaging.... | 02/13/2001 |
| 6177060 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.... | 01/23/2001 |
| 6153172 | Reflective microspheres for ultrasonic imaging The present invention provides a method of contrast enhanced ultrasonic diagnostic imaging comprising administering to a subject a contrast enhancing amount of spheres or particles comprising a matrix enclosing a contrast agent which reflects sound waves,... | 11/28/2000 |
