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| Number | Title | Issue Date |
| 7820144 | Receptor selective cannabimimetic aminoalkylindoles Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may include radioactive atoms. Also disclosed are methods of using the disc... | 10/26/2010 |
| 7648695 | Medicaments for chemotherapeutic treatment of disease New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or h... | 01/19/2010 |
| 7402299 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 07/22/2008 |
| 7384623 | High energy phototherapeutic agents High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using ... | 06/10/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7172749 | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharm... | 02/06/2007 |
| 7141235 | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer... | 11/28/2006 |
| 7105151 | Oxygen delivery agents and uses for the same The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery ag... | 09/12/2006 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 7078015 | Ultrasound imaging and treatment Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic dr... | 07/18/2006 |
| 7005120 | Osmotically stabilized microbubble preparations A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wher... | 02/28/2006 |
| 7003345 | System and method for enhancing microscope images of tissue using citric acid and agents of the like A system and method for enhancing images of ex-vivo or in-vivo tissue produced by confocal microscopy, optical coherence tomography, two-photon microscopy, or ultrasound, is provided by applying to the tissue a solution or gel having an effective concentration of ci... | 02/21/2006 |
| 6998107 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 02/14/2006 |
| 6953569 | Mixed gas microbubble compositions A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wher... | 10/11/2005 |
| 6939531 | Ultrasonic imaging system utilizing a long-persistence contrast agent A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ration of from about 1:100 to abut 1000:1, and wherei... | 09/06/2005 |
| 6933721 | Method and apparatus for enhanced fat saturation during MRI The present invention provides for a method for using a silicon dioxide (SiO2) material that is equally effective in improving magnetic field homogeneity during MR imaging. The present invention further provides for using silicon dioxide in its granular s... | 08/23/2005 |
| 6818202 | Enhancement of NMR and MRI in the presence of hyperpolarized noble gases The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improv... | 11/16/2004 |
| 6652833 | Functionalized active-nucleus complex sensor A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus comp... | 11/25/2003 |
| 6596258 | Method of obtaining extracellular and intracellular pH images and spectra by magnetic resonance using extrinsic indicators containing 1H or 19F The present invention refers to the use of a selection of imidazole compounds in a method of obtaining extracellular or intracellular pH images in biological systems, by magnetic resonance, consisting of administering the imidazole compound to said biolog... | 07/22/2003 |
| 6593144 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 07/15/2003 |
| 6586592 | Bis-arylsulfones The present invention provides pharmaceutically active compounds useful for the treatment of diseases or disorders of the central nervous system.... | 07/01/2003 |
| 6562319 | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as... | 05/13/2003 |
| 6493570 | Method for improved imaging and photodynamic therapy The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy ("PDT") agent. In particular, the apparatus and method is for imaging and treating diseased tissue.... | 12/10/2002 |
| 6426058 | Enhancement of NMR and MRI in the presence of hyperpolarized noble gases The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance... | 07/30/2002 |
| 6420436 | Imaging contrast media and methods of use This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the gastrointestinal (GI) tract; an improved fluorocarbon composit... | 07/16/2002 |
| 6417384 | Radioiodinated phospholipid ether analogs and methods of using the same The present invention provides improved radioiodinated phospholipid ether analogs which demonstrate significant tumor avidity and longer plasma half-life than shorter-chain analogs. The radioiodinated phospholipid ether analogs of the present invention pr... | 07/09/2002 |
| 6315981 | Gas filled microspheres as magnetic resonance imaging contrast agents Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.... | 11/13/2001 |
| 6241966 | Magnetic resonance imaging using Hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 06/05/2001 |
| 6177059 | GPIb-lipid complex and uses thereof A complex comprising a lipid and a conjugate of GPIb and lipid having a functional group, and use thereof. The GPIb-lipid complex of the present invention is extremely useful as a platelet substitute, a pharmaceutical agent for the prophylaxis and treatme... | 01/23/2001 |
| 6123919 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 09/26/2000 |
| 6103216 | Hepatocyte-selective oil-in-water emulsion A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell-selective delivery vehicle. Radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoa... | 08/15/2000 |
| 6042809 | Administrable compositions and methods for magnetic resonance imaging The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations, methods of making the compositions and formulations and contrast... | 03/28/2000 |
| 5922304 | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.... | 07/13/1999 |
| 5851510 | Hepatocyte-selective oil-in-water emulsion A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell-selective delivery vehicle. Radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis›7-(3-amino-2,4,6-triiodophenyl)heptano... | 12/22/1998 |
| 5843404 | Detection of hypoxia Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compo... | 12/01/1998 |
| 5827502 | Microparticulate microbubble-generating contrast agents The present invention relates to contrast agents comprising microbubble-generating carbohydrate particles having a surfactant admixed within the microparticulate structure, wherein the microbubbles generated by the microparticles comprise a biocompatible ... | 10/27/1998 |
| 5811581 | Process for the purification of opacifying contrast agents A process for the purification of opacifying contrastographic agents, comprising chromatographic and nanofiltration techniques combined together, the subsequent chromatographic separation of the crude product solution and a nanofiltration step, with a fin... | 09/22/1998 |
| 5785953 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 07/28/1998 |
| 5785950 | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them This invention relates to compositions comprising highly fluorinated, chloro-substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of making and using them. More particularly, this invention relates to emulsions comprising ... | 07/28/1998 |
| 5770181 | Composition and method for delivering active agents This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the gastrointestinal (GI) tract; an improved fluorocarbon composit... | 06/23/1998 |
