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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8003078 | Targeted MR imaging agents MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of targe... | 08/23/2011 |
| 7988950 | Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (MRI) which contain a chelating moiety with polyhydroxylated substituents The present invention relates to a novel class of paramagnetic ion-based contrast i agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic i profile analo... | 08/02/2011 |
| 7807140 | Magnetic resonance imaging contrast agents synthesized using ring-opening metathesis polymerization Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedica... | 10/05/2010 |
| 7608249 | Enhanced substrate imaging by reversible binding to a paramagnetic complex The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a reversible binding of the substrate molecule to a paramagnetic chela... | 10/27/2009 |
| 7524483 | Responsive paramagnetic MRI contrast agents A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent. ... | 04/28/2009 |
| 7438893 | Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ... | 10/21/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7279150 | Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ... | 10/09/2007 |
| 7255875 | Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ... | 08/14/2007 |
| 7235227 | Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as... | 06/26/2007 |
| 7229606 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 06/12/2007 |
| 7226578 | Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear ... | 06/05/2007 |
| 7211241 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging. ... | 05/01/2007 |
| 7208139 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable comp... | 04/24/2007 |
| 7186399 | Methods for targeted drug delivery A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c)... | 03/06/2007 |
| 7128895 | Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed. ... | 10/31/2006 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 7078015 | Ultrasound imaging and treatment Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic dr... | 07/18/2006 |
| 7074387 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as NMR shift reagents. | 07/11/2006 |
| 7047058 | Apparatuses, systems and methods for extravasation detection An apparatus for the detection of extravasation in an imaging procedure includes at least a first source of energy to supply imaging energy to tissue in the vicinity of a site and at least a first sensor to measure a signal resulting from the energy supplied to the ... | 05/16/2006 |
| 6998107 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 02/14/2006 |
| 6951639 | 1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them 1,4,7,10-Tetraazacyclodedecane butyltriols of general formula IA in which R1 means hydrogen or a metal ion equivalent independent of one another and ... | 10/04/2005 |
| 6916461 | Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear ... | 07/12/2005 |
| 6906050 | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis Substituted porphyrin and azaporphyrin deviations with various substitutents in the 12- and 17-positions of the porphyrin skeleton as pharmaceutical agents for use in photodynamic therapy, MRI diagnosis, and radiodiagnostics. ... | 06/14/2005 |
| 6818203 | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) a... | 11/16/2004 |
| 6803030 | Bile acids conjugates with metal ion chelates and the use thereof Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.). ... | 10/12/2004 |
| 6676928 | Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use Perfluoroalkyl-containing complexes with polar radicals of general formula I in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex, and Z represents a linker group, are suitable for intravenous lymphography... | 01/13/2004 |
| 6641797 | Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use Perfluoroalkyl-containing complexes with sugar radicals of general formula I ##STR1## in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position, Rf means a perfluorinated ca... | 11/04/2003 |
| 6565830 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Compounds of formula I ##STR1## wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.... | 05/20/2003 |
| 6548044 | Imaging sexual response The present invention relates to methods for contrast-enhanced imaging of sexual response. In particular, the present invention relates to methods of magnetic resonance imaging (MRI), computerized X-ray tomography (CT), ultrasound, and optical imaging usi... | 04/15/2003 |
| 6521209 | Bifunctional detection agents The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.... | 02/18/2003 |
| 6468502 | Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nucl... | 10/22/2002 |
| 6461588 | Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries... | 10/08/2002 |
| 6342598 | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarbox... | 01/29/2002 |
| 6337064 | Manganese chelates with high relaxivity in serum Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging. ##STR1##... | 01/08/2002 |
| 6287538 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1, R2, R3 a... | 09/11/2001 |
| 6254850 | Metal complexes, suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and an... | 07/03/2001 |
| 6248306 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polymer complexes containing a) complexing ligands of general formula I A--{X--[Y--(Z--( W--Kw)z)y ]x }a (I) in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, ind... | 06/19/2001 |
| 6232295 | Cell-specific contrast agent and gene delivery vehicles A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule havi... | 05/15/2001 |
| 6193950 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab... | 02/27/2001 |
