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| Number | Title | Issue Date |
| 8017105 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 09/13/2011 |
| 7438893 | Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ... | 10/21/2008 |
| 7279150 | Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ... | 10/09/2007 |
| 7270799 | Perturbed membrane-binding compounds and methods of using the same The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for uti... | 09/18/2007 |
| 7235227 | Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as... | 06/26/2007 |
| 7229606 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 06/12/2007 |
| 7211241 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging. ... | 05/01/2007 |
| 7208139 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable comp... | 04/24/2007 |
| 7198776 | Metal complex compounds The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said me... | 04/03/2007 |
| 7186400 | Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy Compounds of general formula (I): in which: R1 is hydrogen, C1–C20 alkyl, C3–C10 cycloalkyl, C4–C20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyc... | 03/06/2007 |
| 7175829 | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SD... | 02/13/2007 |
| 7132513 | Bifunctional chelating agent The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO2, —NH2, —NCS, —NHCOCH2-Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or —NHCO(CH2)m... | 11/07/2006 |
| 7074387 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as NMR shift reagents. | 07/11/2006 |
| 7060250 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 06/13/2006 |
| 7045606 | Bifunctional chelating agent for actinium The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z, NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or NHCO(CH2)m-Q where Q is a hapt... | 05/16/2006 |
| 7033841 | Process and compounds for use in detecting analytes by measurement of residual magnetism, and the use of the said compounds The invention relates to a process for quantitative detection of analytes in liquid and solid phases with the aid of binding remanence measurement, compounds that are suitable for this purpose, and their use in analytic chemistry. ... | 04/25/2006 |
| 7029655 | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's dise... | 04/18/2006 |
| 7011815 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 03/14/2006 |
| 6960418 | Organophotoreceptor with charge transport material with two N,N,N-trisubstituted-amino groups Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 11/01/2005 |
| 6861045 | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SD... | 03/01/2005 |
| 6818203 | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) a... | 11/16/2004 |
| 6803030 | Bile acids conjugates with metal ion chelates and the use thereof Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.). ... | 10/12/2004 |
| 6709646 | Bioactivated diagnostic imaging contrast agents The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. ... | 03/23/2004 |
| 6676928 | Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use Perfluoroalkyl-containing complexes with polar radicals of general formula I in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex, and Z represents a linker group, are suitable for intravenous lymphography... | 01/13/2004 |
| 6676929 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PP... | 01/13/2004 |
| 6652835 | Targeting multimeric imaging agents through multilocus binding The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant... | 11/25/2003 |
| 6641797 | Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use Perfluoroalkyl-containing complexes with sugar radicals of general formula I ##STR1## in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position, Rf means a perfluorinated ca... | 11/04/2003 |
| 6589506 | Method for magnetic resonance imaging of the lung A method for the assessment of pulmonary ventilation and lung perfusion through Magnetic Resonance Imaging (MRI), comprising the steps of: positioning a human subject in an MRI apparatus, delivering a hyperpolarized noble gas to the subject by inhalation, foll... | 07/08/2003 |
| 6565830 | DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production Compounds of formula I ##STR1## wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.... | 05/20/2003 |
| 6521209 | Bifunctional detection agents The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.... | 02/18/2003 |
| 6468502 | Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nucl... | 10/22/2002 |
| 6403055 | Diagnostic imaging contrast agent with improved in serum relaxivity Compounds of formula (I): ##STR1## are used as their paramagnetic chelates as contrast agents in magnetic resonance imaging. These compounds have high affinity to plasma proteins and exhibit extremely high values of relaxivity in serum and are thus u... | 06/11/2002 |
| 6337064 | Manganese chelates with high relaxivity in serum Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging. ##STR1##... | 01/08/2002 |
| 6312664 | Biodegradable contrast media for MR imaging A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone structure, each spacer arm terminating in at least one paramagnet... | 11/06/2001 |
| 6303761 | Triaminepentaacetic acid compound and paramagnetic metal complex prepared from using the compound as ligand The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of the present invention can be used as a contrast agent for... | 10/16/2001 |
| 6254850 | Metal complexes, suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and an... | 07/03/2001 |
| 6248306 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polymer complexes containing a) complexing ligands of general formula I A--{X--[Y--(Z--( W--Kw)z)y ]x }a (I) in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, ind... | 06/19/2001 |
| 6232295 | Cell-specific contrast agent and gene delivery vehicles A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule havi... | 05/15/2001 |
| 6193950 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab... | 02/27/2001 |
| 6183724 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab... | 02/06/2001 |
