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| Number | Title | Issue Date |
| RE43274 | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferativ... | 03/27/2012 |
| 8133473 | Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy... | 03/13/2012 |
| 8133474 | Sensors for fluorescence and magnetic resonance imaging The present invention generally relates to agents and compositions having MRI and/or optical signals, and methods for their use in the determination of an analyte. In some cases, an optical, MRI, or other signal produced by the agent or composition may be affected b... | 03/13/2012 |
| 7897140 | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photos... | 03/01/2011 |
| 7537751 | Labeling reagents and labeled targets comprising nonmetallic porphyrins This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful ... | 05/26/2009 |
| 7371742 | Porphyrin derivatives for photodynamic therapy This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells, bacteria, tumorous tissues. The invention also relates to compositions contai... | 05/13/2008 |
| 7354568 | Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ... | 04/08/2008 |
| 7344704 | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as... | 03/18/2008 |
| 7341711 | Porphyrin compounds and their use in high-field MRI A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided: in which R0 and R′0 are such that the compoun... | 03/11/2008 |
| 7306785 | Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound... | 12/11/2007 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7279585 | Lipophilic electrophoretic probes Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can b... | 10/09/2007 |
| 7265100 | Separation of regioisomers of metal phthalocyanines The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as phototherapeutic and photodiagnostic agents ... | 09/04/2007 |
| 7244841 | Porphyrin derivatives and their use in photodynamic therapy A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated... | 07/17/2007 |
| 7217531 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 05/15/2007 |
| 7198775 | Detectably labeled porphyrin compound for identifying the sentinel lymph node A detectably labeled porphyrin compound for identifying a sentinel lymph node in patients, particularly those with cancer. A method of identifying a sentinel lymph node, comprising the steps of: injecting the detectably labeled porphyrin compound into a tumor, where... | 04/03/2007 |
| 7192650 | Element having porphyrin polymer fixed on a substrate and method of preparing the same A photo-functional molecule element having, on a substrate, a porphyrin polymer containing covalently-fixed porphyrin units, and the method of preparing the same. The photo-functional molecule element may be used as a photoelectric conversion element such as an orga... | 03/20/2007 |
| 7193237 | Organic semiconductor material and organic electronic device An organic semiconductor material comprising a compound which has a generalized porphyrin skeleton and which has a molecular structure such that the distance from the generalized porphyrin ring plane to the center of each atom forming the generalized porphyrin skele... | 03/20/2007 |
| 7166719 | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferativ... | 01/23/2007 |
| 7153956 | Cyanine dye having multifunctional peripheral groups The present invention provides an IR-absorbing dye of formula (I) or (II) wherein R10, R13, R20, R23, R30, R33, R40 and R | 12/26/2006 |
| 7148345 | Synthetically expedient water-dispersible IR dyes having improved lightfastness The present invention provides an IR-absorbing naphthalocyanine dye of formula (I): wherein M is selected from Ga(A1); A1 is an axial ligand selected from —OH, ha... | 12/12/2006 |
| 7147840 | Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof A compound having the structural formula: where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 132-Oxo-bacteriopyropheophorbide—a carboxylic acid a... | 12/12/2006 |
| 7138391 | Hydrophilizable and hydrophilic cyanine dyes The present invention provides an IR-absorbing dye of formula (I) or (II): wherein Q1, Q2, Q3 and Q4 are the same or different and are independently select... | 11/21/2006 |
| 7122076 | Synthetically expedient water-dispersible IR dyes The present invention provides an IR-absorbing naphthalocyanine dye of formula (I): wherein M is selected from Si(A1)(A2), Ge(A1)(A2)... | 10/17/2006 |
| 7112671 | Non-symmetric tripyrranes in the synthesis of novel macrocycles The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, ... | 09/26/2006 |
| 7110808 | Method of optimizing radiosurgery and radiotherapy with metalloporphyrins An apparatus and method for subsequent optimization of radiosurgery and radiotherapy is provided. The invention includes administering a metalloporphyrin to the patient, and then creating a 3-dimensional mapping of tissue through use of PET or SPECT. Malignant and p... | 09/19/2006 |
| 7097826 | Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy... | 08/29/2006 |
| 7094866 | Covalently fixed porphyrin polymer having porphyrin metal complex substituted with coordinating hetero aromatic ring as constituting unit thereof,and method of producing the same A covalently linked linear porphyrin polymer represented by formula (1): wherein R represents an alkyl group or | 08/22/2006 |
| 7087214 | Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases The invention relates to novel, water-soluble porphyrin platinum compounds of the tetraarylporphyrin platinum derivatives type or of the hematoporphyrin platinum derivatives type with high tumor selectivity and their use for the treatment of benign and malignant tum... | 08/08/2006 |
| 7078014 | Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals A method for MR imaging that comprises conducting the MR imaging after injecting compositions that are chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99, Gad... | 07/18/2006 |
| 7070937 | Marker useful for detection and measurement of free radical damage and method The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presenc... | 07/04/2006 |
| 7067276 | Method of using metaloporphyrins for treatment of arteriosclerotic lesions A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a radioactive metal. Cells which exhibit an affinity for the porphyrin e... | 06/27/2006 |
| 7067504 | Di-steroidal prodrugs of ethinyl estradiol The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I: ... | 06/27/2006 |
| 7067505 | Di-steroidal prodrugs of estradiol The present invention is a di-steroidal prodrug of estradiol having the following formula: ... | 06/27/2006 |
| 7053210 | Efficient synthesis of pyropheophorbide a and its derivatives A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, wit... | 05/30/2006 |
| 7030105 | Method of synthesis of β-thiolato cobalamin compounds The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH, specifically from one to less than four molar equivalents of GluSH. The... | 04/18/2006 |
| 7026347 | Porphyrin-polyamine conjugates for cancer therapy Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conju... | 04/11/2006 |
| 7022840 | Porphyrin array exhibiting large two photon absorption property and including, as structural unit, bis (imidazolylporphyrin metal complex) linked with acetylenic bond and the derivative thereof, and method of producing the same A porphyrin array exhibiting a large two-photon absorption property, and being linked with an acetylenic bond(s), represented by the following formulas: wherein R1 represents an alkyl or aryl group, M1 | 04/04/2006 |
| 7019132 | Porphyrin derivatives The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing singlet state oxygen radical and the inventive compounds have superior adva... | 03/28/2006 |
| 7018395 | Photodynamic treatment of targeted cells The present invention is drawn to methods for photodynamic therapy (PDT) of a target cell, target tissue or target composition in a mammalian subject, using a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent... | 03/28/2006 |
