Class 424/9.361 - Heterocyclic compound is attached to or complexed with the metal

Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the metal is attached to or complexed
No. of patents: 103
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173106	Pharmaceutical composition of peptide drug and enzyme-inhibition compounds The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject. ...	05/08/2012
7727512	Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ...	06/01/2010
7419654	Charge neutral complexes of paramagnetic metals as intracellular magnetic resonance imaging contrast agents A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3 with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the para...	09/02/2008
7354568	Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ...	04/08/2008
7354433	Disinfection, destruction of neoplastic growth, and sterilization by differential absorption of electromagnetic energy Neoplastic tissue, viral and bacterial infections, and other physiological disorders and conditions are treated by irradiation of the host with electromagnetic radiation at a wavelength that is differentially absorbed by the offending tissue or cells. Radiation with...	04/08/2008
7344704	Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as...	03/18/2008
7341711	Porphyrin compounds and their use in high-field MRI A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided: in which R0 and R′0 are such that the compoun...	03/11/2008
7338651	Multi-use multimodal imaging chelates Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester ...	03/04/2008
7279150	Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ...	10/09/2007
7235227	Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as...	06/26/2007
7226578	Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear ...	06/05/2007
7214190	Apparatus and method for noninvasive monitoring of analytes in body fluids Noninvasive in vivo real time analyte measurement uses a multitude of sensors binding reversibly to the analyte whereby the response of the sensors to a noninvasive stimulus is altered by their bound versus unbound state. The stimulus and responses are electromagnet...	05/08/2007
7198775	Detectably labeled porphyrin compound for identifying the sentinel lymph node A detectably labeled porphyrin compound for identifying a sentinel lymph node in patients, particularly those with cancer. A method of identifying a sentinel lymph node, comprising the steps of: injecting the detectably labeled porphyrin compound into a tumor, where...	04/03/2007
7097826	Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy...	08/29/2006
7029655	Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's dise...	04/18/2006
7015309	Pyrrhocoricin-derived peptides, and methods of use thereof Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R1-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X′-Y′-R2 SEQ ID NO: 1 or multimeri...	03/21/2006
7011815	Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ...	03/14/2006
6932960	N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and/or their metal chelates. Use of N-substi...	08/23/2005
6916461	Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear ...	07/12/2005
6911457	Diabetes imaging probes The present invention relates to novel imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions. ...	06/28/2005
6895340	Method of molecular structure recognition An analytical method and apparatus using principal component analysis of nuclear magnetic resonance (NMR) data for rapid molecular structure/function pattern recognition. The presence of a molecular substructure in an organic compound is determined by comparing prin...	05/17/2005
6875419	Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R,...	04/05/2005
6770020	Method of using gadolinium neutron capture to treat cancers Described is a method of using gadolinium-containing compounds as agents for neutron capture therapy to treat neoplastic cell growth. The subject is exposed to a gadolinium-containing compound for a time sufficient to allow the compound to accumulate in neoplastic c...	08/03/2004
6689775	Uses of thioredoxin The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting...	02/10/2004
6686458	Synthetic molecules that specifically react with target sequences The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenic...	02/03/2004
6656448	Matrix metalloproteinase inhibitors Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties;a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targetin...	12/02/2003
6652835	Targeting multimeric imaging agents through multilocus binding The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant...	11/25/2003
6517814	Macrocyclic chelants useful for metallopharmaceuticals Macrocyclic chelant are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and compositions. Therapeutic and imaging methods of use are also disclosed....	02/11/2003
6426059	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polmer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging....	07/30/2002
6315978	Bioconjugates and delivery of bioactive agents The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which comprise of bioactive...	11/13/2001
6299859	Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab...	10/09/2001
6294152	Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging A compound of formula (I): ##STR1## wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and comp...	09/25/2001
6177060	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging....	01/23/2001
6166200	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Cascade polymer complexes that contain a) complexing ligands of general formula I A--{X--[Y--(Z--W--KW z)y ]x}a (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, i...	12/26/2000
6146615	Contrast agents for image enhancement in magnetic resonance imaging A compound of formula (I): ##STR1## wherein, R1, R2, R3 and R4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R1, R2 and ...	11/14/2000
6045821	Liposomal agents The present invention relates to a liposomal agent comprising liposomes having bound to a membrane thereof a chelated diagnostically or therapeutically effective metal ion. The chelating agent binding the metal ion has a macrocyclic chelant moiety with, a...	04/04/2000
6022524	Process for the conjugation of chelants with molecules containing amino groups A process for the preparation of macromolecular chelants characterized by a high content in chelant groups per macromolecule....	02/08/2000
6019959	Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis Oligomeric compounds that contain perfluoroalkyl of general formula I A--RF (I) in which A is a molecule portion that contains 2-6 metal complexes that are connected directly or via a linker to a nitrogen a...	02/01/2000
6010682	Liposoluble compounds useful as magnetic resonance imaging agents Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other ...	01/04/2000
6004529	Chelating agents The invention provides a complexant compound of formula I R3 S (CR12)n N(R2)i (CR12)n X(CR12)n N(R2)i (CR1...	12/21/1999

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Class 424/9.361 - Heterocyclic compound is attached to or complexed with the metal