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Class 424/9.351 - The region of the imaging agent responsibile for binding to an in vivo target or the region of the target responsible for binding to the agent is specifically recited functionally or as a sequence of amino acids, carbohydrate residues, or nucleic acids


Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the carbohydrate attached to said
No. of patents: 13
Last issue date: 09/30/2008


NumberTitleIssue Date
7429381Production and use of novel peptide-based agents for use with bi-specific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antib...
09/30/2008
7208138Contrast enhancement agent for magnetic resonance imaging
Imaging agents for magnetic resonance imaging are disclosed. Methods of monitoring angiogenesis and the growth and remission of tumor tissue are also disclosed. Methods of monitoring blood clot formation and dissolution are additionally disclosed. Methods of monitor...
04/24/2007
6984374Method for the evaluation of implantable materials
A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the ...
01/10/2006
6849403Apparatus and method for drug screening
The present invention provides kits and methods for screening drugs and drug candidates for activity by determining the presence or absence of high integrity nucleic acid in a sample. ...
02/01/2005
6576746Site-specific labeling of disulfide-containing targeting vectors
A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and bearing at least one thiol-containing moiety linked thereto...
06/10/2003
6409990Macromolecular carrier for drug and diagnostic agent delivery
New macromolecular carriers for drugs and diagnostic agents are described that make use of the chemical attachment of new leashes to oligomeric backbone structures. The synthesis of these leashes and their facile creation, reaction and conjugation with ch...
06/25/2002
6268351Methods for inducing proliferation in auditory receptor epithelium
The present invention provides novel methods for stimulating proliferation in auditory receptor epithelium. Administration of agents that activate cAMP production result in demonstrable regeneration of hair cells in the cochlea. These agents may be admini...
07/31/2001
5965131Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species i...
10/12/1999
5958408Delivery of diagnostic and therapeutic agents to a target site
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species i...
09/28/1999
5886143Hepatic-directed compounds and reagents for preparation thereof
Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic me...
03/23/1999
5789554Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells
A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclonal antibody has been recombinantly joined to the human kapp...
08/04/1998
5580543Method of magnetic resonance image enhancement
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutr...
12/03/1996
5260050Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for nuclear magnetic resonance imaging. A polyatomic complex which...
11/09/1993
 
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