Class 424/9.3 - Magnetic imaging agent (e.g., NMR, MRI, MRS, etc.)

Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein a compound or composition is adapted
No. of patents: 427
Last issue date: 02/16/2010

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Number	Title	Issue Date
7662362	Nanoparticulate probe for in vivo monitoring of tissue oxygenation A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative co...	02/16/2010
7622102	Method for monitoring early treatment response Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the tissue adjoining or surrounding the cancerous tissue befo...	11/24/2009
7560096	Diagnostic procedures using direct injection of gaseous hyperpolarized Xe and associated systems and products A method of screening for pulmonary embolism uses gaseous phase polarized 129Xe which is injected directly into the vasculature of a subject. The gaseous 129Xe can be delivered in a controlled manner such that the gas substantially dissolves in...	07/14/2009
7553479	Heat stable colloidal iron oxides coated with reduced carbohydrates and uses thereof Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamag...	06/30/2009
7459144	Process for preparation of MR contrast agents The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogen...	12/02/2008
7438894	Dyes for organ function monitoring Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti...	10/21/2008
7438893	Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ...	10/21/2008
7427391	Formulations for use in medical and diagnostic procedures The present invention relates to formulations for use in medical or diagnostic procedures comprising a stabilizing agent alone or in combination with an osmotic agent. In one embodiment, the stabilizing agent is a natural hydrocolloid, preferably locust bean gum, an...	09/23/2008
7419654	Charge neutral complexes of paramagnetic metals as intracellular magnetic resonance imaging contrast agents A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3 with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the para...	09/02/2008
7412279	Systems and methods for targeted magnetic resonance imaging of the vascular system This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Me...	08/12/2008
7410634	Tissue metabolic stress monitoring Various pathophysiological states are determined by evaluating the rate of 17O-containing water production oxygen using proton MRI. The method can be used to identify viable but threatened myocardium, injured by viable muscle, penumbra tissue in a stroke ...	08/12/2008
7407646	Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic i...	08/05/2008
7385041	Dual functioning excipient for metal chelate contrast agents A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient, Xm[X′(L′)]n, which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safet...	06/10/2008
7385395	Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improv...	06/10/2008
7373782	Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life produ...	05/20/2008
7371365	Methods for detecting parenchymal plaques in vivo Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amy...	05/13/2008
7368254	Lipid-based systems for targeting diagnostic agents The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting from increased levels of extracellular PLA2 activity in the di...	05/06/2008
7368910	Dual gradient echo pulse sequence using interleaved spiral-out spiral-in k-space trajectories Measurements of functional, hemographic, and blood flow parameters use a multiple echo or spin echo gradient pulse sequence whereby an early echo is acquired near the beginning of the pulse sequence which avoids saturation effects and a later echo near the end of th...	05/06/2008
7368099	MRI contrast agents An MRI contrast agent enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent includes an imaging unit which contains an unpaired electron-carrying atom and/or molecule and is capable of amplifying or reducing MRI signal...	05/06/2008
7364859	Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge...	04/29/2008
7362840	Circuit and method for adjusting timing alignment using programmable codes A method is provided for adjusting timing alignment in which a receiver generates a plurality of imbalanced correction codes (1310), and square waves both having the same frequency. The receiver mixes the imbalanced correction codes with the square waves to c...	04/22/2008
7361336	Methods of cancer therapy targeted against a cancer stem line Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer t...	04/22/2008
7357917	Diagnostic procedures using Xe spectroscopy characterstic chemical shift to detect pathology in vivo An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized 129Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chem...	04/15/2008
7354568	Magnetic resonance imaging agents for the detection of physiological agents The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances. ...	04/08/2008
7351402	Polarizing agents for dynamic nuclear polarization We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two paramagnetic centers. In a preferred embodiment, the polarizing agent compri...	04/01/2008
7344704	Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration 1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as...	03/18/2008
7344698	Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ...	03/18/2008
7341738	Lipid-encapsulated polyanionic nucleic acid Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid ...	03/11/2008
7341711	Porphyrin compounds and their use in high-field MRI A new use in magnetic resonance imaging employing a field greater than 1.5 Tesla, of a porphyrin compound of the following general formula I is provided: in which R0 and R′0 are such that the compoun...	03/11/2008
7338651	Multi-use multimodal imaging chelates Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester ...	03/04/2008
7332111	Devices and methods for the production of particles The present invention provides methods and devices for producing particles with an average diameter less than about 15 μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-B...	02/19/2008
7330748	Method for determining in vivo concentration of a metabolite Method for determining in vivo concentration of a metabolite that includes administering a contrast agent to a subject, allowing the contrast agent to disperse to tissue of interest, performing CEDST MRI analysis of the subject, and comparing the results to known in...	02/12/2008
7329402	Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The...	02/12/2008
7326402	Method of diagnosing, monitoring, staging, imaging and treating cancer The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer. ...	02/05/2008
7320784	Immobilized labeling compounds and methods The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the support; and collecting the metal-conjugate complex released from th...	01/22/2008
7306785	Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound...	12/11/2007
7304171	Compounds and methods for cytoprotection Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically accepta...	12/04/2007
7303741	Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, a...	12/04/2007
7291295	Method for precipitating finely divided solid particles A method for precipitation of finely divided solid particles comprising a) Dissolving a compound C in a fluid A to provide a solution A; b) Thermostatization of said solution A to a temperature ranging between −50°0 C. and 200° C.;...	11/06/2007
7287390	Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods Hyperpolarizers for producing polarized noble gases can include: (a) a control module configured to direct the operation of a hyperpolarizer to produce polarized noble gas via spin-exchange interactions between a noble gas and an alkali metal; (b) at least one optic...	10/30/2007

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Class 424/9.3 - Magnetic imaging agent (e.g., NMR, MRI, MRS, etc.)