Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 4999191 | Pasteurella multocida vaccine Mutogenesis of the Clemson University (CU) vaccine strain of P. multocida with N-methyl-N-nitro-N-nitrosoguanidine resulted in temperature sensitive (TS) mutants which grew at 37° C. but not 42° C. Two mutants, PM#1 and PM#3, were found to provide turke... | 03/12/1991 |
| 4770875 | Process for preparation of improved mutant strain of Bordetella bronchiseptica useful for live attenuated vaccine for protection of B. bronchiseptica infection and live attenuated AR vaccine produced therefrom A process for the preparation of a mutant strain of B. bronchiseptica having chromosomal genetic markers carrying at least temperature-sensitive (grown at 42° C.), nalidixic acid-resistant and heat-labile dermonecrotic toxin producing ability negative ma... | 09/13/1988 |
| 4681762 | Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype The present invention relates to a vaccine composition for the prevention of infectious diseases comprising an immunogenically-effective amount of a genetically attenuated and stable avirulent bacterial strain derived from a virulent bacterial strain by i... | 07/21/1987 |
| 4456588 | Method of the preparation of improved mutant strain of Bordetella bronchiseptica useful as live attenuated vaccine for prophlaxis of B. bronchiseptica infection A method for the preparation of a new mutant strain of Bordetella bronchiseptica having a plural of hereditary chromosomal markers of at least temperature-sensitivity and urease negative, more particularly a phase I mutant strain of B. bronchiseptica havi... | 06/26/1984 |
| 4379140 | Turkey rhinotracheitis vaccine A live vaccine against Alcaligenes faecalis, for application to turkeys, containing a temperature-sensitive non-virulent genetically stable strain of Alcaligenes faecalis having good immunizing capabilities and the absence of adverse side-effects.... | 04/05/1983 |
| 4337314 | Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype A vaccine composition comprising a genetically attenuated bacterial strain which contains at least two mutations of the same phenotype which strain is rendered avirulent while retaining immunogenicity.... | 06/29/1982 |
