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| Number | Title | Issue Date |
| 7381421 | Liposomes Polyanionic therapeutic compounds, generally nucleic acids, are complexed with calcium phosphate and entrapped within liposomes. For DNA vaccines, the complexation and entrapment process provides improved immune response for gene vaccines delivered intramuscularly. | 06/03/2008 |
| 7358226 | Ultrasonic concentration of drug delivery capsules Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation is used to fragment the localized carriers, releasing associate compou... | 04/15/2008 |
| 7160554 | Enhanced circulation effector composition and method A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the ... | 01/09/2007 |
| 7150882 | Enhanced circulation effector composition and method A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the ... | 12/19/2006 |
| 7122553 | Liposomal formulation of irinotecan The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include liposome entrapped irinotecan in which the li... | 10/17/2006 |
| 7041634 | Method of inhibiting immune system destruction of transplanted viable cells This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a devi... | 05/09/2006 |
| 6793923 | Vaccines with enhanced immune response and methods for their preparation The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen encapsulated in liposomes, a suitable adjuvant and a carrier comprising a con... | 09/21/2004 |
| 6787154 | Artificial antigen presenting cells The present invention is directed to artificial antigen presenting cells and methods of making artificial antigen presenting cells. Such artificial antigen presenting cells may be used in certain methods of isolating and expanding T cell populations as well as modul... | 09/07/2004 |
| 6761914 | Immunogenic formulations comprising oil bodies The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the vaccines and the use of the vaccines to elicit an immune response. ... | 07/13/2004 |
| 6759057 | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs Methods and compositions are described for the treatment of inflammatory diseases including the use of liposomes to deliver non-steroidal anti-inflammatory drugs. Drugs may be encapsulated in the liposomes during their preparation, or alternatively, are combined wit... | 07/06/2004 |
| 6663886 | Inhibition of cell-cell binding by lipid assemblies This invention relates generally to the field of therapeutic compounds designed to interfere between the binding of ligands and their receptors on cell surface. More specifically, it provides products and methods for inhibiting cell migration and activati... | 12/16/2003 |
| 6403117 | Archaesomes, archaeosomes containing coenzyme Q10 and other types of liposomes containing coenzyme Q10 adjuvants and as delivery vehicles Novel archaeosome compositions and their use in vaccine formulations as adjuvants and/or delivery systems, to enhance the immune response to immunogens in an animal such as a human, are described. Another aspect relates to the use of these archaeosomes to... | 06/11/2002 |
| 6368619 | Hydrophobic preparations of hydrophilic species and process for their preparation Single phase preparations of hydrophilic species, in particular macromolecular compounds such as proteins or glycoproteins in a hydrophobic solvent such as an oil can be obtained by preparing a hydrophile/amphiphile array in which the hydrophilic head gro... | 04/09/2002 |
| 6350466 | Targeted polymerized liposome diagnostic and treatment agents Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with... | 02/26/2002 |
| 6333038 | Prophylaxis of allergic disease The invention provides a method for preventing allergic disease in an individual susceptible to such disease, comprising administering an allergen to which the individual has not been sensitized previously. The allergen is administered in a dose and form ... | 12/25/2001 |
| 6322810 | Materials and methods for making improved micelle compositions Provided are methods for preparing improved biologically active micelle and crystalline products comprising a biologically active amphipathic compound in association with a micelle or crystalline product. Methods for producing the micelle or crystalline p... | 11/27/2001 |
| 6316024 | Therapeutic liposome composition and method of preparation Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting co... | 11/13/2001 |
| 6294191 | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.... | 09/25/2001 |
| 6287568 | Methods relating to immunogenic dextran-protein conjugates This invention includes the conception of T-independent conjugate-vaccines and its application in the induction of antigen specific IgA response. We demonstrated that 1) (1,6)dextran can elicit a markedly enhanced IgA response in T-cell free mice (... | 09/11/2001 |
| 6258378 | Delivery of biologically active substance to target sites in the body of patients The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formu... | 07/10/2001 |
| 6221386 | Use of virulence factors of pathogens to improve liposomal delivery of therapeutic agents Liposome encapsulated antibiotic therapy has limited application against infectious organisms, which can sequester in non-phagocytic cells. Virulence factors of these infectious organisms, for example bacterial components, when used in the formulation of ... | 04/24/2001 |
| 6183772 | Doped colorimetric assay liposomes The present invention provides compositions comprising colorimetric assay liposomes. The present invention also provides methods for producing colorimetric liposomes and calorimetric liposome assay systems. In preferred embodiments, these calorimetric lip... | 02/06/2001 |
| 6180135 | Three-dimensional colorimetric assay assemblies A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flue virus. The assemblies are typically in the form of liposomes which can be maintained in a s... | 01/30/2001 |
| 6165502 | Protein-lipid vesicles and autogenous vaccine comprising the same A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is u... | 12/26/2000 |
| 6156337 | Method for high loading of vesicles with biopolymeric substances A method for loading liposomes with biopolymeric substances functional in humans involves combining a physiologically compatible solution of the biopolymeric substances with one or more dry, liposome-forming lipids, effecting a lipid-containing fraction, ... | 12/05/2000 |
| 6139869 | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surfa... | 10/31/2000 |
| 6132789 | Archaeosomes, archaeosomes containing coenzyme Q10, and other types of liposomes containing coenzyme Q10 as adjuvants and as delivery vehicles Novel archaeosome compositions and their use in vaccine formulations as adjuvants and/or delivery systems, to enhance the immune response to immunogens in an animal such as a human, are described. Another aspect relates to the use of these archaeosomes to... | 10/17/2000 |
| 6126938 | Methods for inducing a mucosal immune response The invention relates to a pharmaceutical composition intended for inducing in a host mammal a protective immune response against an antigen, at a mucosal effector site, which comprises at least two identical or different products each containing an induc... | 10/03/2000 |
| 6124270 | Use of a cationic amphipathic compound as a transfection agent, vaccine additive or drug A cationic amphipathic compound of formula (I), ##STR1## wherein A is a single bond, an NH--R' grouping or (a), wherein --R'-- is a straight or branched, optionally substituted, saturated or unsaturated C1-22 aliphatic chain optionally int... | 09/26/2000 |
| 6107102 | Therapeutic microdevices and methods of making and using same A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am range. Also disclosed are microfabrication methods for making s... | 08/22/2000 |
| 6090406 | Potentiation of immune responses with liposomal adjuvants A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and u... | 07/18/2000 |
| 6071495 | Targeted gas and gaseous precursor-filled liposomes Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in the... | 06/06/2000 |
| 6054133 | Anti-microbial targeting for intracellular pathogens A method and composition are provided for treating intracellular pathogens that reside in phagosomes. The compositions include antibiotics which are conjugated with transferrin or other ligands to form conjugates that target membrane-bound pathogens. The ... | 04/25/2000 |
| 6022874 | Piperazine based cytofectins The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nit... | 02/08/2000 |
| 6004534 | Targeted polymerized liposomes for improved drug delivery The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to co... | 12/21/1999 |
| 5993852 | Biphasic lipid vesicle composition for transdermal administration of an immunogen A composition for transdermal administration of an immunogen is described. The immunogen is entrapped in lipid vesicles having a oil-in-water emulsion in the central core compartment. The vesicles are administered transdermally to elicit an immune respons... | 11/30/1999 |
| 5976538 | Adjuvant composition containing synthetic hydrophobic lipopolysaccharide According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups, while maintaining the overall hydrophobicity, an interface-for... | 11/02/1999 |
| 5932224 | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV polymerase, and are particularly useful in treating or preventing HBV infec... | 08/03/1999 |
| 5925362 | Method to elicit an antitumor response with human prostate-specific antigen Vaccines capable of eliciting an immune antitumor response for prostate tumors are disclosed. The active ingredient in such vaccines is selected from the group consisting of human PSA and expression system capable of generating in situ human PSA.... | 07/20/1999 |
| 5914127 | Isolation and uses of caveolae Methods of isolating and purifying caveolae, microdomains of GPI-anchored proteins, and membranes consisting essentially of caveolae associated with microdomains of GPI-anchored proteins from endothelial cell membranes are disclosed. The methods comprise ... | 06/22/1999 |
