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| Number | Title | Issue Date |
| 8003089 | Y shape branched hydrophilic polymer derivatives, their preparation methods, conjugates of the derivatives and drug molecules, and pharmaceutical compositions comprising the conjugates The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates. ... | 08/23/2011 |
| 7964182 | Pharmaceutical compositions comprising phosphate-binding polymer The present invention discloses pharmaceutical composition comprising phosphate binding polymers such as Sevelamer carbonate substantially free of monovalent anion other than bicarbonate anion. Particularly, monovalent anion content is less than about 0.05% (w/w). D... | 06/21/2011 |
| 7846426 | Compositions and methods for treating and preventing cardiomyopathy and heart disease The present invention relates to compositions and methods for treating and preventing heart disease. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188—P188) and methods of using the same for treating and preventi... | 12/07/2010 |
| 7311902 | Conjugates comprising human IL-18 and substitution mutants thereof Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjuga... | 12/25/2007 |
| 7241813 | End-capped polymers and compositions containing such compounds End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula: and may be combin... | 07/10/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7202225 | Therapeutic delivery compositions and methods of use thereof The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition comprising an administerable admixture of an effective amount of a nucleic ac... | 04/10/2007 |
| 7199089 | Liquid preparation for contact lens comprising a disinfectant and buffer mixture A liquid preparation for a contact lens is provided, including at least one disinfectant selected from the group consisting of germicidal biguanides and germicidal quaternary ammonium salts (Component A), glycolic acid and/or asparatic acid (Component B), and 2-amin... | 04/03/2007 |
| 7135554 | Method of forming a polymerized hemoglobin solution from stabilized hemoglobin A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, th... | 11/14/2006 |
| 7128924 | Safe, eco-friendly, health protective herbal colors and aroma useful for cosmaceutical applications The invention relates to a novel safe and eco-friendly health protective and beauty enhancing herbal compositions having various cosmetic applications such as lipsticks, eye shadows, glow-glitters and rouges, said compositions containing colorants from plants of the... | 10/31/2006 |
| 7094369 | Processes for manufacturing polymeric microspheres Processes of manufacturing polymeric microspheres facilitate the generation of polymeric microspheres of size ranges smaller than 600 microns diameter by forming beads of a predetermined size from a starting material which may include a template polymer, and subsequ... | 08/22/2006 |
| 7052686 | Pegylated interleukin-10 Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 a... | 05/30/2006 |
| 7045589 | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block ... | 05/16/2006 |
| 7045552 | Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a fina... | 05/16/2006 |
| 7041281 | Natural feel polymers Natural feel polymers exhibit an advantageous blend of flexibility and a strong affinity to natural fibers imparting a natural feel when applied to keratin-based fibers, e.g. hair, skin, or textiles, e.g. cotton, wool, and are water-soluble and water-resistant. The ... | 05/09/2006 |
| 7030082 | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The f... | 04/18/2006 |
| 7018625 | Personal care compositions Personal care compositions, particularly hair care products, include a polymer mixture made from (A) a derivatized polymer of maleic anhydride having defined repeat units of a monomer (e.g. α-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and... | 03/28/2006 |
| 7005125 | Personal care products Personal care products, particularly hair care products, are made herein by mixing (A) a polymer having defined repeat units of a monomer (e.g. α-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and maleimide, which is derivatized with an amine... | 02/28/2006 |
| 6989362 | Methods of treating dopamine dysregulation using agents that regulate phosphorylation/dephosphorylation in dopamine signaling The present invention discloses that DARPP-32 is substrate for the cyclin dependent kinase Cdk5. The phosphorylation takes place at a specific threonine residue of DARPP-32 (Threonine 75). The Cdk5 catalyzed phosphorylation of DARPP-32 converts this protein into an ... | 01/24/2006 |
| 6930090 | Methods of activating a receptor using amphiphilic drug-oligomer conjugates The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugate comprises a therapeutic compound conjugated to ... | 08/16/2005 |
| 6911427 | No-modified hemoglobins and uses therefore S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used which are not specific only for thiol groups, but which nitrosate Hb mor... | 06/28/2005 |
| 6732573 | Single riser/single capillary blood viscometer using mass detection or column height detection An apparatus and method for determining the viscosity of the circulating blood of a living being over plural shear rates caused by a decreasing pressure differential by monitoring the changing weight of the blood, or the changing level of a column of blood over time... | 05/11/2004 |
| 6645483 | Lubricious coating A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is... | 11/11/2003 |
| 6630167 | Hyaluronic acid anti-adhesion barrier Methods of forming crosslinked hyaluronic acid anti-adhesion barriers, crosslinked hyaluronic acid anti-adhesions barriers, methods for preventing or inhibiting adhesions, and methods of promoting healing of a wound are provided. The method of forming the... | 10/07/2003 |
| 6464970 | Method and composition for preventing surgical adhesions An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. T... | 10/15/2002 |
| 6419916 | Assay for compounds which affect conformationally altered proteins An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected neuroblastoma cells. Another assay comprises contacting organ or tiss... | 07/16/2002 |
| 6387391 | Bioresorbable polymeric clayey and sticky substance This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40° C... | 05/14/2002 |
| 6299868 | Fat-binding polymers The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a med... | 10/09/2001 |
| 6277889 | Molluscicide formulation A molluscicide containing a non-toxic animal repellant and metaldehyde, in which the molluscicidal efficacy of the molluscicide greater than that of the molluscicide if it did not contain repellant. The repellant may be an anthranilate compound or d-puleg... | 08/21/2001 |
| 6271264 | Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polyme... | 08/07/2001 |
| 6214366 | Clearance and inhibition of conformationally altered proteins The present invention provides a method of arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing insoluble protein deposit burden by the administration of branched polycationic compound... | 04/10/2001 |
| 6190688 | Material for elimination or detoxification of super antigens A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provid... | 02/20/2001 |
| 6048523 | Polyester cyclic compounds, their complexes and bonded bodies It is provided a polyester cyclic compound represented by formula (1). It is also provided a complex of a polyester cyclic compound represented by formula (1), (3) or (4) and a compound containing an OH group(s). It is still further provided a bonded body... | 04/11/2000 |
| 6037387 | Blood-compatible material of a supramolecular structure A platelet metabolism suppressing blood compatible material has a supramolecular structure containing a plurality of cyclic compounds and a hydrophilic straight-chain polymer threading into cavities of the cyclic compounds. Both terminals of the polymer a... | 03/14/2000 |
| 5962566 | Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery The presently claimed invention comprises a biopolymer nanoparticle for drug delivery wherein the nanoparticle comprises a homogeneous blend of an aliphatic polyester polymer blended with a polyether, a lipophilic or polypeptide drug and a biocompatible c... | 10/05/1999 |
| 5939537 | Acid-functionalized saccharide monomers The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a s... | 08/17/1999 |
| 5928633 | Material for elimination or detoxification of super antigens A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provid... | 07/27/1999 |
| 5922682 | Polyol esters, their preparation and use in depot forms of pharmacologically active agents This invention provides a polyester of a polyol, said polyol containing at least 3 hydroxyl groups and having a molecular weight of up to 20,000 at least 1 hydroxyl group in said polyol being in the form of an ester, with a poly- or co-poly-lactic acid re... | 07/13/1999 |
| 5919830 | Stable non-aqueous blends for personal care compositions A stable non-aqueous carrier for personal care compositions comprising: a) about 80-98% by weight of a liquid polyoxyalkylene glycol of MW=3000-100000; b) about 2-20% by weight of a non-ionic solid triblock EO/PO/EO copolymer of MW=8500-25,000.... | 07/06/1999 |
| 5902589 | Method for treating hydratable polymers, compositions obtained therefrom, and methods of using same Aqueous solutions of hydratable polymers are prepared by hydrating a hydratable polymer in water without agitation sufficient to shear the molecular structure of the polymer thereby maintaining intact the polymer's molecular structure thereby providing a ... | 05/11/1999 |
