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| Number | Title | Issue Date |
| 8440176 | Covalently grafted pharmaceutically active polymers The invention relates to graftable polymers comprising biologically active agents and the use of such polymers in the manufacture of shaped articles, such as implantable medical devices and catheters. The graftable polymers are covalently grafted to a surface via on... | 05/14/2013 |
| 8431113 | Polymer conjugates The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled polymerisation processes for producing the conjugates. An initiation f... | 04/30/2013 |
| 8420069 | Antimicrobial and antifouling polymeric materials A polymeric material, methods of making the polymeric material, articles that include the polymeric material, and compositions that contain the polymeric material are provided. The polymeric material has a plurality of different pendant groups that include a first p... | 04/16/2013 |
| 8383093 | Subcutaneous delivery of poly(oxazoline) conjugates The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety. ... | 02/26/2013 |
| 8349309 | Polymeric coupling agents and pharmaceutically-active polymers made therefrom A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B (I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio (II) | 01/08/2013 |
| 8343473 | Hydrophilized antimicrobial polymers A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of t... | 01/01/2013 |
| 8252276 | Cyclodextrin-based polymers for therapeutics delivery The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug... | 08/28/2012 |
| 8197802 | Method for treating or inhibiting the formation of adhesions following surgery or injury Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a syntheti... | 06/12/2012 |
| 8182802 | Composition of polymers Compositions are described comprising a of a block copolymer having an overall ionic charge and in which one of the blocks has pendant zwitterionic groups and a biologically active compound having a charge opposite that of the polymer. The polymer is preferably a li... | 05/22/2012 |
| 8153112 | Compositions and methods for treating cavity conditions Compositions, methods and kits to be used as a lubricant and for treatment of a cavity pathology including joint pathology are provided. The composition comprises therapeutically effective amounts of at least one bioactive agent, such as magnesium compound, at least... | 04/10/2012 |
| 8153111 | Photo-triggered release of active substances from dendrimer-photosensitizer complexes Compositions of dendrimer-photosensitizer complexes including therapeutic molecules, and methods for their synthesis and use are disclosed. The therapeutic molecules and the photosensitizers are each covalently attached to the dendrimer at its end-groups, essentiall... | 04/10/2012 |
| 8119115 | Antiviral method This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes an alcohol, and an enhancer selected from the group consisting of cat... | 02/21/2012 |
| 8110179 | Cyclodextrin-based polymers for therapeutics delivery The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug... | 02/07/2012 |
| 8101164 | Dual phase drug release system The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect at... | 01/24/2012 |
| 8048408 | Polymer conjugates The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled polymerisation processes for producing the conjugates. An initiation f... | 11/01/2011 |
| 7883694 | Method for preventing the formation of adhesions following surgery or injury Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a syntheti... | 02/08/2011 |
| 7858080 | Aldehyde conjugated flavonoid preparations There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to f... | 12/28/2010 |
| 7790150 | Dual phase drug release system The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect at... | 09/07/2010 |
| 7736636 | Method for treating occlusive vascular diseases & wound healing Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of Nicotine, nicotinic acid analogs thereof, their combination with or without other pro-angiogenesis factors, vasodi... | 06/15/2010 |
| 7556799 | Ion binding polymers and uses thereof The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmac... | 07/07/2009 |
| 7419504 | Poly(ester amide) block copolymers Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can ob... | 09/02/2008 |
| 7361726 | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The medical articles generally comprise an implantable substrate having a ... | 04/22/2008 |
| 7351787 | Process for the preparation of activated polyethylene glycols A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the... | 04/01/2008 |
| 7273845 | Polymeric prodrugs of vancomycin Methods of preparing vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are preferably releasable, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related compounds. Vancomycin-polymer... | 09/25/2007 |
| 7265186 | Multi-arm block copolymers as drug delivery vehicles The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attache... | 09/04/2007 |
| 7214382 | Self-warming or self-heating cosmetic and dermatological compositions and method of use This invention relates to cosmetic applications for topical applications to the human skin. In particular, it relates to anhydrous cosmetic and dermatological compositions, with the capacity for self-warming or self-heating upon application. The self-warming or self... | 05/08/2007 |
| 7202225 | Therapeutic delivery compositions and methods of use thereof The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition comprising an administerable admixture of an effective amount of a nucleic ac... | 04/10/2007 |
| 7202325 | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The medical articles generally comprise an implantable substrate having a ... | 04/10/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7192736 | Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, ... | 03/20/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7166702 | Cytotoxic conjugates comprising a chemokine receptor targeting agent Conjugates containing as a ligand chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune... | 01/23/2007 |
| 7157418 | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders Conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immu... | 01/02/2007 |
| 7125558 | Process for the preparation of activated polyethylene glycols The present invention relates to a process for the preparation of activated polyethylene glycols, or PEG(NPC)2s, comprising reacting polyethylene glycol with an activator while in the presence of an aromatic nitrogen containing heterocyclic base. The proc... | 10/24/2006 |
| 7119074 | Treatment of cancers, tumors and malignancies using amphiphilic prodrugs The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the central nerv... | 10/10/2006 |
| 7118737 | Polymer-modified synthetic proteins The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides met... | 10/10/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
| 7084121 | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. M... | 08/01/2006 |
| 7056713 | Urate oxidase The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modifie... | 06/06/2006 |
| 7052686 | Pegylated interleukin-10 Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 a... | 05/30/2006 |
