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Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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| Number | Title | Issue Date |
| 7976834 | Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide se... | 07/12/2011 |
| 7968085 | Hydrogel formulations A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openi... | 06/28/2011 |
| 7947261 | Conjugates formed from polymer derivatives having particular atom arrangements Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent ... | 05/24/2011 |
| 7947263 | Biocompatible surgical compositions Biocompatible synthetic macromer compositions are provided including a first polymer having multiple functional groups and a second functionalized polyurethane prepolymer, which can be employed as an adhesive or sealant for medical/surgical uses. ... | 05/24/2011 |
| 7947262 | Use of fullerenes for the treatment of mast cell and basophil-mediated disease Mast cell (MC) and peripheral blood basophil (PBB)-associated diseases are treated or prevented, or their symptoms are alleviated by the administration of water soluble fullerenes (buckeyballs) to the individual under conditions sufficient to inhibit MC and PBB resp... | 05/24/2011 |
| 7939055 | Polymeric aromatic N-halo sulfonamides A polymer comprises a monomer having a N-halo sulfonamide pendant group and having the formula: wherein A is a trivalent linkage; wherein Q is a divalent linkage and y is 0 or 1; wherein R1... | 05/10/2011 |
| 7914776 | Solid dispersions of opioid antagonists Solid dispersions of stable, amorphous opioid antagonists, particularly [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid, with improved water solubility and bioavailability are disclosed. Also disclosed are m... | 03/29/2011 |
| 7858078 | Bioabsorbable surgical composition Bioabsorbable macromer compositions are provided including a diisocyanate-functional bioabsorbable polymer. In some embodiments, the diisocyanate-functional bioabsorbable polymer can be combined with a functionalized polyol. The resulting bioabsorbable macromer comp... | 12/28/2010 |
| 7858079 | Tissue adhesives and sealants and method for their use Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses. ... | 12/28/2010 |
| 7794700 | Multimeric VLA-4 antagonists comprising polymer moieties Disclosed are conjugates exhibiting VLA-4 antagonistic properties. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. The conjugates of this invention are characterized as containing more than one VL... | 09/14/2010 |
| 7771711 | Sphingolipids' polyalkylamines conjugates The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a... | 08/10/2010 |
| 7625552 | Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a c... | 12/01/2009 |
| 7597882 | Protein crosslinkers, crosslinking methods and applications thereof Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological ... | 10/06/2009 |
| 7588754 | Biodegradable polyacetals and methods Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (I). Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications. ... | 09/15/2009 |
| 7442370 | Polymer conjugates of mutated neublastin A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin. ... | 10/28/2008 |
| 7323167 | Method of treatment with modified arginine deiminase The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis. ... | 01/29/2008 |
| 7316811 | Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide se... | 01/08/2008 |
| 7311901 | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also r... | 12/25/2007 |
| 7300662 | Drug/drug delivery systems for the prevention and treatment of vascular disease A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia f... | 11/27/2007 |
| 7294278 | Method for oxygenating wastewater A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo... | 11/13/2007 |
| 7291713 | Branched polyalkylene glycols The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group... | 11/06/2007 |
| 7288416 | Ionic polymers and polymer-comprising substrates An objective of the present invention is to provide ionic polymers that can provide for polymer-comprising substrates whose surfaces can stably and easily immobilize ligands such as sugar chains interacting with biological substances, in which the ligand portion exi... | 10/30/2007 |
| 7273756 | Method for chondrocyte expansion with phenotype retention The present invention provides a method that maintains chondrocyte phenotype during serial expansion by culturing a population of chondrocytes in a defined serum-free culture medium containing cytokines and on a substrate that is modified by covalent attachment of h... | 09/25/2007 |
| 7238828 | Absorbable α-cyanoacrylate compositions A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1: | 07/03/2007 |
| 7230068 | Polymer derivatives The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp... | 06/12/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7226586 | Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high N... | 06/05/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7224050 | Plastic materials including dendrimers or hyperbranched polymers for integrated circuit packaging Integrated circuit packages and their manufacture are described, wherein the packages comprise dendrimers or hyperbranched polymers. In some implementations, the dendrimers or hyperbranched polymers include repeat units having one or more ring structures and having ... | 05/29/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7208145 | Polymeric reagents comprising a ketone or a related functional group Polymeric reagents comprising a polymer attached, either directly or through one or more atoms to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioke... | 04/24/2007 |
| 7199089 | Liquid preparation for contact lens comprising a disinfectant and buffer mixture A liquid preparation for a contact lens is provided, including at least one disinfectant selected from the group consisting of germicidal biguanides and germicidal quaternary ammonium salts (Component A), glycolic acid and/or asparatic acid (Component B), and 2-amin... | 04/03/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7179867 | Thermosensitive biodegradable copolymer A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or —C(═O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with function... | 02/20/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7166733 | O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes The present invention relates to amidomalonate O,O′—Pt and N,O—Pt chelates and methods of preparing them in essentially pure form. ... | 01/23/2007 |
| 7138520 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent. ... | 11/21/2006 |
| 7125558 | Process for the preparation of activated polyethylene glycols The present invention relates to a process for the preparation of activated polyethylene glycols, or PEG(NPC)2s, comprising reacting polyethylene glycol with an activator while in the presence of an aromatic nitrogen containing heterocyclic base. The proc... | 10/24/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
