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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 8075921 | Rapamycin-resistant T cells and therapeutic uses thereof Methods for generating highly enriched Th1/Tc1 and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced pur... | 12/13/2011 |
| 8062675 | Mesenchymal precursor cell A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differen... | 11/22/2011 |
| 8057826 | Methods for reducing graft-versus-host disease using pluri-differentiated mesenchymal progenitor cells The present invention provides isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), which simultaneously express a plurality of genes that are markers for multiple cell lineages, wherein the multiple cell lineages comprise at least four different... | 11/15/2011 |
| 8021693 | Methods of organ regeneration using Hox11-expressing pluripotent cells The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of the pancreas, liver cells, spleen cells, or bone cells, that has inju... | 09/20/2011 |
| 7892578 | Treatment of hematologic disorders The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the inventio... | 02/22/2011 |
| 7838041 | Method for treating multiple myeloma The present invention relates to methods for the treatment of multiple myeloma. More particularly, the present invention relates to a method for inducing apoptosis in myeloma cells by administration of a K121-like antibody. ... | 11/23/2010 |
| 7799350 | Use of cytokines and mitogens to inhibit graft versus host disease A method for inducing T cell tolerance in peripheral blood mononuclear cells (PBMCs) comprising adding a suppressive composition to said cells. ... | 09/21/2010 |
| 7799349 | Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which method... | 09/21/2010 |
| 7794756 | Methods of using antibodies to VEGF-C Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that... | 09/14/2010 |
| 7744927 | Methods of promoting hematopoietic and mesenchymal cell proliferation and differentiation The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (AI), AI analogues,... | 06/29/2010 |
| 7691415 | Method for preventing, or reducing the severity of, graft-versus-host disease using pluri-differentiated mesenchymal progenitor cells There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such ... | 04/06/2010 |
| 7670628 | Mesenchymal precursor cell A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differen... | 03/02/2010 |
| 7658951 | Method of improving cardiac function of a diseased heart A method of treating heart failure and improving cardiac function by administering stem cell products to a heart in need of treatment, whereby the stem cell products improve cardiac muscle function thereby treating heart failure and improving cardiac function. A met... | 02/09/2010 |
| 7618654 | Mammalian myeloid progenitor cell subsets A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate into lymphoid lineages. This population is further divided into speci... | 11/17/2009 |
| 7582313 | Methods of organ regeneration using -expressing pluripotent cells The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of the pancreas, liver cells, spleen cells, or bone cells, that has inju... | 09/01/2009 |
| 7563459 | Methods and compositions for regenerating tissue The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering stem... | 07/21/2009 |
| 7465464 | Populations of cells that express flk-2 receptors Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the ... | 12/16/2008 |
| 7445798 | Populations of cells that express FLK-1 receptors Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the ... | 11/04/2008 |
| 7442390 | Method for enhancing engraftment of cells using mesenchymal progenitor cells The present invention provides isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), which simultaneously express a plurality of genes that are markers for multiple cell lineages, wherein the multiple cell lineages comprise at least four different... | 10/28/2008 |
| 7429383 | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells... | 09/30/2008 |
| 7425331 | Protein A methods of use Methods and compositions for modulating an immune response in a subject are provided. Methods include administering to the subject a composition comprising an effective amount of a lymphocyte differentiation factor, e.g., protein A (PA), sufficient to modulate the i... | 09/16/2008 |
| 7386154 | Method to identify the mechanical properties of a material Method to identify the mechanical properties of a material starting from at least a digitalized image of a sample of the material. The image of the sample to be analyzed is processed to achieve a numerical model comprising a determinate number of elementary geometri... | 06/10/2008 |
| 7355696 | Method and apparatus for sorting cells Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a ... | 04/08/2008 |
| 7309501 | Conditioned media to inhibit growth of tumor cells Conditioned media compositions having valuable biological activity are obtained from cultures of immune cells from elasmobranch fishes. A method is provided for producing the conditioned media compositions. Conditioned media obtained using epigonal cells from bonnet... | 12/18/2007 |
| 7303769 | Method for purifying pluri-differentiated mesenchymal progenitor cells There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such ... | 12/04/2007 |
| 7294331 | Methods of using flt3-ligand in hematopoietic cell transplantation Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to Flt3-ligand as an isolated protein, the DNA encoding the Fl... | 11/13/2007 |
| 7282222 | Methods and compositions for directing cells to target organs The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering stem... | 10/16/2007 |
| 7282201 | Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin This invention has as its object providing promoters of the growth and/or differentiation of hematopoietic stem cells and/or hematopoietic progenitors which are useful as therapeutics of diseases that result from insufficient growth and/or differentiation of hematop... | 10/16/2007 |
| 7232566 | Methods for treating HIV infected subjects Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 06/19/2007 |
| 7211258 | Protein A compositions and methods of use The invention provides methods for modulating an immune response in a subject including, for example, administering to the subject a composition comprising an effective amount of a lymphocyte differentiation factor sufficient to modulate the immune response. In one ... | 05/01/2007 |
| 7195758 | Methods of inducing a T cell mediated immune response by administering antigen presenting B cells We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B cells can be obtained from peripheral blood in large numbers. These ce... | 03/27/2007 |
| 7175843 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 02/13/2007 |
| 7173016 | Composition and method for treating graft-versus-host disease Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pento... | 02/06/2007 |
| 7144575 | Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the... | 12/05/2006 |
| 7138144 | Method of inducing immune tolerance via blood/lymph flow-restricted bone marrow transplantation A method of inducing tolerance to a transplant transplanted from a donor to a subject is disclosed. The method comprises (a) restricting outflow of a fluid from a portion of the circulatory system of the subject; and (b) administering a dose of bone marrow cells der... | 11/21/2006 |
| 7129070 | Targeted system for removing tumor cells from cell populations A method is presented for killing a first population of cells within a mixture of viable cells by providing the mixture of viable cells, contacting the cells with a label, illuminating a portion of the mixture, capturing an image of multiple cells in the illuminated... | 10/31/2006 |
| 7122178 | Mesenchymal precursor cell A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differen... | 10/17/2006 |
| 7029666 | Uses for non-autologous mesenchymal stem cells Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and ... | 04/18/2006 |
| 7029671 | Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof The invention relates to a method for activating human-derived antigen-presenting cells by in vitro cultivation with at least one of the glycoside compounds represented by formula (A) or salts thereof [preferred example: (2S,3S,4R)-1-(α-D-galactopyranosyloxy)-2-hex... | 04/18/2006 |
| 6984383 | Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r... | 01/10/2006 |
