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| Number | Title | Issue Date |
| 8114437 | Solvent/polymer solutions as suspension vehicles A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The ... | 02/14/2012 |
| 8110220 | Temperature sensitive polymers The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly ploy (hydroxyalkyl (meth) acrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application ... | 02/07/2012 |
| 8092833 | Compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 01/10/2012 |
| 8075916 | Poly(organophosphazene) hydrogels for drug delivery, preparation method thereof and use thereof A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided. ... | 12/13/2011 |
| 8057821 | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationi... | 11/15/2011 |
| 8048450 | Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation An aqueous dispersion of hydrogel nanoparticles and methods of making the aqueous dispersion of hydrogel nanoparticles having an interpenetrating polymer network (“IPN”) are described. The uniformed sized mono-disperse IPN nanoparticles have inverse thermo gelat... | 11/01/2011 |
| 8029824 | Hydrogel of (semi) interpenetrating network structure and process for producing the same A hydrogel of the semi-interpenetrating network structure or interpenetrating network structure, characterized in that the hydrogel is one formed from a first monomer ingredient at least 10 mol % of which is accounted for by a charge-possessing unsaturated monomer, ... | 10/04/2011 |
| 8017151 | Amphiphilic polymer-protein conjugates and methods of use thereof Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided. ... | 09/13/2011 |
| 8007828 | Stabilized biodegradable neurotoxin implants Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effec... | 08/30/2011 |
| 7993675 | Solvating system and sealant for medical use in the sinuses and nasal passages Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming m... | 08/09/2011 |
| 7985424 | Dendritic polymers with enhanced amplification and interior functionality Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to ... | 07/26/2011 |
| 7985423 | Porous bodies and method of production thereof Porous bodies which are soluble or dispersible in non-aqueous media comprising a three dimensional open-cell lattice containing (a) 10 to 70% by weight of a polymeric material which is soluble in water immiscible non-aqueous media and (b) 30 to 90% by weight of a su... | 07/26/2011 |
| 7981444 | Dendritic polymers with enhanced amplification and interior functionality Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-function... | 07/19/2011 |
| 7968123 | Complexing agents for compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 06/28/2011 |
| 7964217 | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor This invention relates to hydrolytically degradable gels of crosslinked poly(ethylene) glycol (PEG) structures. Addition of water causes these crosslinked structures to swell and become hydrogels. The hydrogels can be prepared by reacting two different PEG derivativ... | 06/21/2011 |
| 7959948 | Pharmaceutical composition of quetiapine fumarate A pharmaceutical composition comprising (i) quetiapine or a pharmaceutically acceptable salt thereof, especially quetiapine fumarate; (ii) a mixed excipient comprising an intimate admixture of polyvinylacetate and polyvinylpyrrolidone in a weight ratio from 5:2 to 1... | 06/14/2011 |
| 7931916 | Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration. The invention relates to a biocompatible composition which comprises microparticles of alginic acid or its salts and an active... | 04/26/2011 |
| 7919118 | Spacer moiety for poly (ethylene glycol) modified peptide based compounds The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water-soluble polymer moiety. The spacer moiet... | 04/05/2011 |
| 7883722 | Controlled release composition A composition for controlled delivery of at least one active substance into an aqueous medium by erosion at a preprogrammed rate of at least one surface of the composition, the composition comprising a matrix which is erodible in the aqueous medium in which the comp... | 02/08/2011 |
| 7879356 | Polymeric compositions The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or prevent... | 02/01/2011 |
| 7879357 | Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients The invention relates to a pharmaceutical composition in the form of a hydrogel that comprises a carboxylic acid diester, a C2-C4 alkyl alcohol, an active ingredient and a polymer matrix. The invention also relates to the use of a carboxylic ac... | 02/01/2011 |
| 7850994 | Xerogel films for the controlled release of pharmaceutically active molecules Xerogel films on substrates are provided containing pharmaceutically active compounds. Articles incorporating such films are robust, release active compounds at predictable rates and may provide such release for relatively long periods of time. Orthopedic and trauma... | 12/14/2010 |
| 7850993 | Drug-releasing system of biodegradable polymer type A method for producing compression-melt molded product using polylactic acid powder is described. The method comprises the steps of: 1) heat-melting polylactic acid having a weight-average molecular weight of 3,000-40,000 at 140-220° C., 2) allowing the melted poly... | 12/14/2010 |
| 7833548 | Bioactive agent release coating and controlled humidity method A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous syst... | 11/16/2010 |
| 7829117 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of... | 11/09/2010 |
| 7807198 | Compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 10/05/2010 |
| 7776359 | Stereocomplex hydrogels The invention relates to hydrogel compositions, which can be applied as biodegradable materials and to the processes to prepare such hydrogels. The hydrogel of the present invention comprises a stereocomplex gel structure which is the result of the interaction of ol... | 08/17/2010 |
| 7767229 | Use of poly diallyamine polymers A poly(diallylamine)polymer pharmaceutical composition or pharmaceutical derivate used to sequester bile acid and/or to reduce serum cholesterol levels. The polymer is derived from a monomer of formula Ia, where R6 is a bridging group of valency r, and r ... | 08/03/2010 |
| 7754241 | Macromonomer for preparation of a degradable hydrogel A degradable hydrogel and a method of making a degradable hydrogel is disclosed herein. The method comprises obtaining a hydrophilic polymer having at least two hydroxyl groups, reacting the hydrophilic polymer with a di-functional monomer comprised of an acid halid... | 07/13/2010 |
| 7749539 | Polymeric formulations for drug delivery Poly(ester-anhydrides) or polyesters formed from ricinoleic acid and natural fatty diacids and their method of preparation and its use for delivering bioactive agents including small drug molecules, peptides and proteins, DNA and DNA complexes with cationic lipids o... | 07/06/2010 |
| 7727551 | Oral pharmaceutical compositions with modified release of the active ingredient The present invention relates to modified-release oral pharmaceutical compositions containing one or more active principles solubilized, suspended or embedded in a suitably formulated amphiphilicmatrix which, loaded in hydrophilic matrices, provides different releas... | 06/01/2010 |
| 7727969 | Controlled release nanoparticle having bound oligonucleotide for targeted delivery The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer syst... | 06/01/2010 |
| 7709026 | Low concentration of peroxide for treating or preventing vaginal infections The invention relates to a pharmaceutical vaginal composition for treating or preventing vaginal infections. The composition includes a synergistic mix of a bioadhesive, extended release formulation that decreases the pH and that contains a peroxide in an amount suf... | 05/04/2010 |
| 7700129 | Polymer actuator To provide a polymer actuator which is light in weight and capable of linear expansion and contraction with a low voltage. The polymer actuator 1 is composed of a plurality of gel/electrode complexes arranged in an electrolytic aqueous solution 6 | 04/20/2010 |
| 7670621 | Transdermal administration of (R)-3,3-diphenylpropylamin-monoesters The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted... | 03/02/2010 |
| 7670622 | Composition for in vivo vessel repair The present invention relates to a biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition wherein said biocompatible polymer composition is curable in the presence... | 03/02/2010 |
| 7658946 | Solid supports functionalized with phosphorus-containing dendrimers, process for preparing them and uses thereof The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especi... | 02/09/2010 |
| 7655258 | Biodegradable copolymer, and polymeric micelle composition containing the same A biodegradable copolymer with a core block comprising bioresorbable hydrophobic polyester segment and from 3 to 10 shell blocks comprising hydrophilic polyethylene glycol segment. The hydrophobic polyester segment and each of the hydrophilic polyethylene glycol seg... | 02/02/2010 |
| 7641917 | Method of encapsulating an active substance The invention provides a method of encapsulating an active substance in an interpolymer complex, to make an encapsulated product in particulate form. The method comprises forming a mixture of a supercritical fluid, an interpolymer complex and an active substance and... | 01/05/2010 |
| 7550155 | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses The present invention provides aqueous pharmaceutical compositions containing a lipophilic therapeutic agent. In particular, the invention provides aqueous pharmaceutical compositions containing the compound 2,6-diisopropylphenol (propofol). Preferred compositions o... | 06/23/2009 |
