"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7378109 | Pharmaceutical composition for improving palatability of drugs and process for preparation thereof The present invention discloses compositions, comprising a lipid-polymer matrix to mask the bitter or unpleasant taste of the medicament. The lipid or a blend of lipids, are used in combination with the pH dependent polymer where the said polymer is acid soluble or ... | 05/27/2008 |
| 7067116 | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer, such as pullulan, and a taste masked pharmaceutically active agent, such as dextromethorphan. The taste masking agent is preferably a sul... | 06/27/2006 |
| 7067493 | Single dose azithromycin The present invention relates to a method of treating infections in humans by administering a single dose of azithromycin. ... | 06/27/2006 |
| 6706285 | Enteric coated formulation of a benzimidazole derivative and method for preparation thereof Disclosed are an enteric coated formulation of a benzimidazole derivative comprising a core and a film of an enteric coating agent on the surface thereof, the core containing a complex of the benzimidazole derivative and an ion-exchange resin, and the enteric coatin... | 03/16/2004 |
| 6685962 | Gastroretentive controlled release pharmaceutical dosage forms Pharmaceutical gastroretentive drug delivery systems for the controlled release of an active agent in the gastrointestinal tract are disclosed, which comprise: (a) a single- or multi-layered matrix comprising a polymer that does not retain in the stomach ... | 02/03/2004 |
| 6420473 | Acrylic enteric coating compositions A non-toxic, edible, enteric film coating, dry powder composition for use in making an aqueous enteric suspension which may be used in coating pharmaceutical tablets comprises a) an acrylic resin, said resin comprising i) from 20 to 85 percent by weight o... | 07/16/2002 |
| 6194000 | Analgesic immediate and controlled release pharmaceutical composition Disclosed is a method for the therapeutic treatment of pain related to wind up in a human or animal. The method of the invention is practiced by administering to the subject an effective amount of an analgesic pharmaceutical composition which includes a N... | 02/27/2001 |
| 6066336 | Cholesterol-lowering tablets An improved cholesterol-lowering tablet is manufactured by blending tablet grade cholestyramine with an appropriate amount of lubricant and directly compressing into elongated tablets having a specified thickness. These inner tablets are successfully film... | 05/23/2000 |
| 5980882 | Drug-resin complexes stabilized by chelating agents The invention provides a pharmaceutical composition comprising a drug-resin complex and a chelating agent in which the composition is in the form of a solid or a gel. The invention also provides a method of making such a composition and a method for impro... | 11/09/1999 |
| 5935604 | Nasal drug delivery composition containing nicotine The present invention provides a nasal drug delivery composition comprising nicotine or a pharmacologically-acceptable salt or derivative thereof wherein the composition is adapted to delivery a pulse of nicotine for rapid absorption and a controlled rele... | 08/10/1999 |
| 5840339 | Blood cholesterol reducing pharmaceutical composition A salt comprising the reaction product of nicotinic acid and an anion exchange resin having a degree of crosslinking with divinylbenzene of less than 4%. These salts are useful in reducing blood cholesterol levels.... | 11/24/1998 |
| 5837226 | Ocular microsphere delivery system A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of a ion-exchange resin and a polymeric coating completely surrounding the core wherein ... | 11/17/1998 |
| 5718920 | Particles for binding monovalent cations A method and particles for binding monovalent cations, each of the particles having a nucleus containing a cation exchange material, and applied thereon, a coating comprising a membrane being permeable for monovalent cations, in particular sodium, potassi... | 02/17/1998 |
| 5688510 | Process for producing stable medicinal composition, and pharmaceutical preparation A process for producing a pharmaceutical composition is disclosed. In the process, 1 part by weight of a physiologically inert powdery additive, 0.001-1 part by weight of a macromolecular additive per part by weight of said insert powdery additive, and at... | 11/18/1997 |
| 5654004 | Oral pharmaceutical preparation releasable in the lower digestive tract An oral pharmaceutical preparation releasable in the lower digestive tract, characterized by having a double-coated structure wherein a solid drug having a core containing an active ingredient is covered with both an inner coat made of a cationic polymer ... | 08/05/1997 |
| 5442008 | Stabilized polymer film coated compounds and stabilized formulations in compressed from using same Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations Stabilized compounds of the formula I ##STR1## in which R, R1, R2, R3, R4 and R5 have the stat... | 08/15/1995 |
| 5286493 | Stabilized controlled release formulations having acrylic polymer coating A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of the plasticized acrylic pol... | 02/15/1994 |
| 5271946 | Controlled release azelastine-containing pharmaceutical compositions Azelastine-containing pharmaceutical compositions which provide controlled release of the active substance using a sustained release component. The compositions contain azelastine or a physiologically acceptable salt of azelastine, together with 0.001 to ... | 12/21/1993 |
| 5004614 | Controlled release device with an impermeable coating having an orifice for release of drug Controlled release devices having a core including an active agent and an outer coating which is substantially impermeable to the entrance of an environmental fluid and substantially impermeable to the release of the active agent during a dispensing perio... | 04/02/1991 |
| 4999189 | Sustained release oral suspensions Stable sustained release wax- and polymer-coated drug-ion exchange resin complexes especially useful in preparing oral suspensions are disclosed.... | 03/12/1991 |
| 4996047 | Sustained release drug-resin complexes Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content above a specified value. The drug-resin complex is subseq... | 02/26/1991 |
| 4869908 | Fibre formulations Tablets containing nutritional and therapeutic substances in conjunction with dietrary fibre substances. The tablets can be formulated in two layers which separate the nutritional and therapeutic substances from the fibre.... | 09/26/1989 |
| 4788055 | Resinate sustained release dextromethorphan composition A pharmaceutical preparation for controlled, sustained release of dextromethorphan comprising a polystyrene sulfonate resin which has been cross-linked with about 3% to about 10% divinyl benzene, having an average particle size of at least 48 μm and less... | 11/29/1988 |
| 4762709 | Liquid prolonged release pharmaceutical formulations containing ionic constituents A formulation of a drug wherein the drug is present as a coated, drug-resin complex suspended in a liquid carrier which carrier also contains a second ionic component bearing the same charge as the coated complexed drug, the second ionic component being p... | 08/09/1988 |
| 4663163 | Modified polysaccharide supports A modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly or indirectly to ... | 05/05/1987 |
| 4529583 | Composition and method of immobilizing emetics and method of treating human beings with emetics A therapeutic composition is coated with a mixture of an emetic chemical and an inert material. A method for reducing absorption into the body of a being of an emetic chemical while still retaining localized emetic activity comprises combining prior to in... | 07/16/1985 |
| 4459278 | Composition and method of immobilizing emetics and method of treating human beings with emetics A therapeutic composition is coated with a mixture of an emetic chemical and an inert material. A method for reducing absorption into the body of a being of an emetic chemical while still retaining localized emetic activity comprises combining prior to in... | 07/10/1984 |
| 4221778 | Prolonged release pharmaceutical preparations Prolonged release pharmaceutical preparations containing ion exchange resin drug complexes at least a substantial portion of which have been treated with a solvating agent and provided with a diffusion barrier coating.... | 09/09/1980 |
| 4211763 | Anion exchange resin in the determination of thyroid function In the determination of thyroid function in the triiodothyronine uptake and thyroxine tests, a tablet formed from a strongly basic anion exchange resin is used as a secondary binding agent to separate the bound and unbound radioactive thyroid hormone.... | 07/08/1980 |
| 4175119 | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs A composition and method of inducing emesis to preclude death from accidental or intentional overdosage of a therapeutic composition. The surface of the therapeutic composition is coated with an emetic chemical of such quantity that if the therapeutic com... | 11/20/1979 |
| 4115537 | Resin tablet and use thereof in diagnostic tests Resilient polystyrene anion-exchange resin beads in a size range of 50 to 600 mesh are bound together by microcrystalline cellulose to form a tablet suitable for use in conducting clinical diagnostic tests, and particularly, in making thyroxine determinat... | 09/19/1978 |
| 3964482 | Drug delivery device A drug delivery device for percutaneously administering a drug comprising a plurality of projections, a drug reservoir containing a drug, and where the projections extend from the reservoir and are adapted for penetrating the stratum corneum for percutane... | 06/22/1976 |