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| Number | Title | Issue Date |
| 8029822 | Rupturing controlled release device having a preformed passageway The present invention provides a simple and improved osmotic device that is capable of providing a controlled release of active agent contained in the core first through a preformed passageway and then through an in situ formed second passageway into an environment ... | 10/04/2011 |
| 7955619 | Abuse resistant drugs, method of use and method of making An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comp... | 06/07/2011 |
| 7858119 | Extended release pharmaceuticals An extended release pharmaceutical formulation is disclosed. A selected pharmaceutical agent is encased within polymeric film layers providing for gradual release of the pharmaceutical active for over 12 and even 24 hours in the gastrointestinal tract and the blood ... | 12/28/2010 |
| 7387791 | Liposome drug delivery This invention comprises pharmaceutical compositions for administering a biologically active compound to an animal. Particularly provided are proliposomal compositions that are advantageously used to deliver biologically active compounds to the gastrointestinal trac... | 06/17/2008 |
| 7364585 | Medical devices comprising drug-loaded capsules for localized drug delivery A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer polyelectrolyte shell. The medical device is adapted to apply a press... | 04/29/2008 |
| 7338663 | Expandable osmotic composition and coating suspension The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may ... | 03/04/2008 |
| RE40059 | Sensitive substance encapsulation A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating the plated material under controlled atmosphere and airflow to reduce v... | 02/12/2008 |
| 7318936 | Minimization of drug oxidation in drug irradiated excipients formulations This invention relates to compositions and methods for preventing oxidation of beneficial agents. ... | 01/15/2008 |
| 7316819 | Oral peptide pharmaceutical dosage form and method of production A pharmaceutical composition for oral delivery of a peptide is in the form of a lamination having at least two layers. The first layer of the lamination includes at least one pharmaceutically acceptable pH-lowering agent. The second layer includes a therapeutically ... | 01/08/2008 |
| 7316821 | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated ... | 01/08/2008 |
| 7312040 | Microcapsule biosensors and methods of using the same The present invention relates to the detection of analyte(s) of interest in a test sample using a rupturable microcapsule biosensor. In general, the microcapsule biosensor includes a microcapsule comprising a shell encapsulating a detectable agent and further includ... | 12/25/2007 |
| 7303762 | Absorption enhancers The invention relates to the use of hydrophilic aromatic alcohols to enhance the uptake of molecules, including biologically active macromolecules, into the body across the intestinal wall from the lumen of the gut; to compositions for oral administration which cons... | 12/04/2007 |
| 7300665 | Nocturnal muscle enhancing composition and method A method and nutrient supplement composition for nocturnal administration to human subjects where the nutrient supplement composition includes both a sustained timed release portion and a rapid release portion, both portions containing a mixture of edible food prote... | 11/27/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7276252 | Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isol... | 10/02/2007 |
| 7267718 | Pullulan film compositions The invention concerns compositions based on pullulan and a setting system for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. T... | 09/11/2007 |
| 7264824 | Oral dosage form Oral dosage form for food and food supplement as well as dietetics comprising polyunsaturated acids in a xylose-hardened gelatine capsule with a retarded release time. ... | 09/04/2007 |
| 7258872 | Chromone enteric release formulation Orally administered chromones have been found to be effective in the treatment of allergic conditions such as asthma, general food allergies, ulcerative colitis, atopic eczema, chronic urticaria, and irritable bowel syndrome if it is presented such that the respecti... | 08/21/2007 |
| 7235258 | Sustained-release formulations for treating CNS-mediated disorders Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which a... | 06/26/2007 |
| 7211313 | Surfaces rendered self-cleaning by hydrophobic structures and a process for their production A self-regenerating, self-cleaning hydrophobic surface is formed when particles are secured on a carrier that is itself a mixture of particles and binder. When particles on the surface are ablated by erosion, new particles in the carrier are exposed to regenerate th... | 05/01/2007 |
| 7204312 | Compositions and methods for the delivery of chemical components in subterranean well bores The present invention relates to the delivery of a plurality of chemical components in well bore applications. More particularly, this invention relates to delivery capsules and methods of using such delivery capsules for facilitating the delivery of at least a plur... | 04/17/2007 |
| 7205115 | Method and system for stabilization of arachidonic acid for use in platelet function assay Methods and systems for rapidly determining the level of platelet inhibition in whole blood, due to aspirin usage, with a single use arachidonic based assay device that can be stored at room temperature is provided. A lyophilized assay reagent that contains arachido... | 04/17/2007 |
| 7195769 | Pharmaceutical compositions of anti-tubercular drugs and process for their preparation A pharmaceutical composition of anti-tubercular drugs for oral use comprising Rifampicin and/or Isoniazid wherein the bioavailability of Rifampicin and/or other drugs is enhanced. Preferably the bioavailability of Rifampicin is enhanced by preventing its degradation... | 03/27/2007 |
| 7195778 | Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery The invention is directed to a drug delivery device for controlled release of a drug, comprising a core that has a cylindrical plug embedded therein; and a coating that at least partially surrounds the core. The core is comprised of a drug and excipients. The coatin... | 03/27/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7169450 | Enrobed core An enrobed a core, such as a tablet core, that has a coating made of one or more patterned films each having portions that are visually distinct (e.g., differently colored) from one another and having a transition line segment between these visually distinct portion... | 01/30/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7157095 | Multiple-delayed release antifungal product, use and formulation thereof An anti-fungal product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the Cmax for the anti-fungal product being reached in less than about twelve hours after initial release of anti-funga... | 01/02/2007 |
| 7157102 | Multi-layered microcapsules and method of preparing same A multi-layered microcapsule containing one or more active ingredients and process for preparing the same is disclosed. The multi-layered microcapsule comprises an inner solid microparticle core, typically composed of a biodegradable polymer, and having one or more ... | 01/02/2007 |
| 7153840 | Aqueous fludarabine phosphate composition This invention is directed towards a ready-to-use aqueous composition of fludarabine phosphate. In one embodiment, the invention is directed to an aqueous fludarabine phosphate composition which comprises fludarabine phosphate, a base, and water. The concentration o... | 12/26/2006 |
| 7147867 | Dosage form comprising liquid formulation A dosage form is disclosed comprising a drug formulation that self-emulsifies in the drug formulation. ... | 12/12/2006 |
| 7148207 | Oral fludara of high-purity formulation with quick release of active ingredient This invention relates to a quick-release tablet formulation with >99.19% pure fludara (high-purity fludara) as an active ingredient in a defined composition of residual contaminants. ... | 12/12/2006 |
| 7144585 | Cilostazol preparation Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slight... | 12/05/2006 |
| 7135196 | Iron compositions Compositions in solid form, such as powders, comprising a mixture of a ferrous salt and a hydroxypyrone maybe used to increase the level of iron in a patient's bloodstream or to treat and/or prevent gastrointestinal infection. ... | 11/14/2006 |
| 7125561 | Compartmentalized dosage form The present invention provides provide a dosage form that prevents misuse of the medicament contained within. The dosage form contains an inactivating substance in combination with the medicament, wherein the two substances are separated by a permeable or semi-perme... | 10/24/2006 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7122207 | High drug load acid labile pharmaceutical composition A high drug load spheronized beadlet is provided wherein said beadlet comprises about 80% to 100% by weight of an acid labile medicament, preferably didanosine, about 0% to about 10% by weight of a disintegrant, and about 0% to about 10% by weight of a binder select... | 10/17/2006 |
| 7118762 | Controlled release lipoic acid A controlled release formulation of lipoic acid is disclosed. The lipoic acid is combined with excipient materials in such a way that those materials provide for gradual release of the lipoic acid in a manner which makes it possible to substantially increase the per... | 10/10/2006 |
| 7112361 | Methods of making decomposable thin films of polyelectrolytes and uses thereof A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers. ... | 09/26/2006 |
| 7105174 | Multiple-delayed release anti-neoplastic product, use and formulation thereof An anti-neoplastic product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the Cmax for the anti-neoplastic product being reached in less than about twelve hours after initial release of an... | 09/12/2006 |
