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| Number | Title | Issue Date |
| 8101160 | Formulations for use in inhaler devices A formulation for use in an inhaler device comprises carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm; fine particles of an excipient material having a mass median aerodynamic diameter of not more than 20 μm; and... | 01/24/2012 |
| 8092785 | Process for milling poorly soluble drugs in presence of liquid propellants Drug substance for use in a pharmaceutical formulation may be prepared by a process which process comprises co-milling a suspension of the drug substance and a pharmaceutically acceptable polymer in a liquid propellant. ... | 01/10/2012 |
| 8080236 | Particulate materials Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing the particles or formulations. In one embodiment, an inhaler contains an aerosol f... | 12/20/2011 |
| 8075873 | Method of preparing dry powder inhalation compositions The invention provides a method of preparing a dry powder inhalation composition comprising a pharmaceutically acceptable particulate carrier, a first particulate inhalant medicament and a second particulate inhalant medicament. Also provided are dry powder composit... | 12/13/2011 |
| 8071074 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 12/06/2011 |
| 7914771 | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor The present invention encompasses methods and compositions for the treatment and prevention of chronic obstructive pulmonary disease (COPD) or emphysema, typically smoking-induced emphysema. More specifically, the present invention relates to the treatment and preve... | 03/29/2011 |
| 7842284 | Odor eliminating items and methods of use for hunting A regimen for hunting includes using a number of zeolite-containing personal items in connection with a hunter's apparel and body to reduce the hunter's scent for improved hunting. The personal items include mouthwash, deodorant/anti-perspirant, body and boot powder... | 11/30/2010 |
| 7790145 | Respiratory dispersion for metered dose inhalers A respiratory dispersion is provided for the pulmonary delivery of at least two bioactive agents. The dispersion comprises a propellant suspension medium having dispersed therein a plurality of perforated microstructures, wherein the two bioactive agents are incorpo... | 09/07/2010 |
| 7776315 | Pharmaceutical compositions based on anticholinergics and additional active ingredients A pharmaceutical composition comprising an anticholinergic and at least one additional active ingredient selected from among corticosteroids, dopamine agonistes, PDE-IV inhibitors, NK1-antagonists, endothelin antagonists, antihistamines, and EGFR-kinase inhibitors, ... | 08/17/2010 |
| 7736628 | Powdered inhalants based on modified lactose mixtures as excipient The invention relates to a new process for preparing modified lactose mixtures, these lactose mixtures per se and compositions of medicaments for powder inhalation consisting of one or more micronised active substances and the modified lactose according to the inven... | 06/15/2010 |
| 7718163 | Carrier particles for use in dry powder inhalers A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material (4) on the surfaces of the carrier particles to promote the release of the active particl... | 05/18/2010 |
| 7713518 | Capsule for a powder medicament A capsule for a powder has a body which is provided with an internal chamber (21) to hold the powder and first and second openings to an exterior environment. The body is adapted to be displaced from a filling state, in which the first and second openings are... | 05/11/2010 |
| 7678364 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 03/16/2010 |
| 7666395 | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The compound may be administered as a liquid or dry powder aerosol formulation.... | 02/23/2010 |
| 7628978 | Stabilized preparations for use in metered dose inhalers Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalka... | 12/08/2009 |
| 7628977 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 12/08/2009 |
| 7591999 | Powdery preparation for nasal administration According to the present invention, a powdery preparation for nasal administration comprising a physiologically active substance, a non-water-absorbing and hardly water-soluble powder(s) and one or two selected from the group consisting of a mucolytic agent and a no... | 09/22/2009 |
| 7582284 | Particulate materials The present invention relates to active substances in particulate form, to methods for preparing them, to formulations containing them and to uses of such substances and formulations. A preferred embodiment is directed to particulate suspensions having improved floc... | 09/01/2009 |
| 7541022 | Pharmaceutical formulations for dry powder inhalers A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is sui... | 06/02/2009 |
| 7498020 | Medicaments This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises particulate salbutamol and physiologically acceptable salts and solvates thereof and a fluor... | 03/03/2009 |
| 7481995 | Aerosol composition An aerosol composition comprising a propellant and a first particulate material comprising particles having a median aerodynamic diameter with the range 0.05 to 11 μm, such as a medicament suitable for pulmonary inhalation, and a second particulate material compris... | 01/27/2009 |
| 7473416 | Medicaments for asthma treatment A method and apparatus are disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a soli... | 01/06/2009 |
| 7459146 | Stabilized aerosol dispersions The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant. ... | 12/02/2008 |
| 7442388 | Phospholipid-based powders for drug delivery Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation.... | 10/28/2008 |
| 7442368 | Delivery of stimulants through an inhalation route The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patien... | 10/28/2008 |
| 7435407 | Inhibition of olfactory neurosensory function to treat eating disorders and obesity The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical compo... | 10/14/2008 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7431916 | Administration of medicinal dry powders A method of administering a metered dry powder combined dose of finely divided dry medication powders is disclosed, wherein said method comprises providing a relative motion between a nozzle of a dry powder inhaler and a dose bed carrying said combined dose of finel... | 10/07/2008 |
| 7427607 | Drug administration method A method of administering a drug whereby a fine drug powder can be accurately administered to a target site (in particular, a target site in the body cavity) via fluidization and spraying with a gas by using a micro tube. Concerning the administration mode, in parti... | 09/23/2008 |
| 7417051 | Medicaments comprising betamimetics and a novel anticholinergic A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X− is an anion with a single negative charge; and (b) a betamimetic 2, or a... | 08/26/2008 |
| 7405207 | Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof This invention relates to a sealed container containing a powder formulation comprising a dehydroepiandrosterone, its analogue(s) or salt(s) by itself or with a pharmaceutically or veterinarily acceptable carrier or diluent, and having a particle size of about 0.1 Î... | 07/29/2008 |
| 7399528 | Powder particles with smooth surface for use in inhalation therapy Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by sub... | 07/15/2008 |
| 7393544 | Dispersion for pulmonary delivery of a bioactive agent Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between ... | 07/01/2008 |
| 7368102 | Pulmonary delivery of aminoglycosides The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of aminoglycosides. According to a preferred embodiment, compositions and method... | 05/06/2008 |
| 7368104 | Treatment of respiratory diseases A pharmaceutical composition for pulmonary delivery comprises glycopyrrolate in a controlled release formulation, wherein, on administration, the glycopyrrolate exerts its pharmacological effect over a period greater than 12 hours. ... | 05/06/2008 |
| 7364749 | Preparations for the application of anti-infective and/or anti-inflammatory agents Use of an anti-infective and/or anti-inflammatory agent for the preparation of a pharmaceutical composition for the treatment of diseases of external or internal parts of the human or animal body which are susceptible to the administration of such agents. ... | 04/29/2008 |
| 7357884 | Conductive ink composition A conductive ink composition is obtained by dispersing, in an organic solvent, a solid material made from metal fine particles each coated with protective colloids each made of at least two organic compounds, the metal fine particles consisting of an alloy containin... | 04/15/2008 |
| 7358093 | Aztreonam L-lysine and methods for the preparation and analysis thereof The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam. ... | 04/15/2008 |
| 7354966 | Compounds for use as surfactants Compounds of formula (I): and uses of such compounds are described. ... | 04/08/2008 |
| 7351747 | Skin treatment for relief of itch A method for treating skin itch in an individual in need of such treatment, by topically administering an amount effective for relieving said itch of an additive selected from the group consisting of (a) aluminum chlorohydrates; (b) aluminum zirconium chlorohydrates... | 04/01/2008 |
