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...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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| Number | Title | Issue Date |
| 8012502 | Resorbable thin membranes Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The memb... | 09/06/2011 |
| RE42012 | Compositions and methods for enhancing receptor-mediated cellular internalization Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also... | 12/28/2010 |
| 7850987 | Nutrient composition(s) and system(s) for individualized, responsive dosing regimens Individualized responsive dosing nutrient systems, compositions, methods of dosing, and processes of producing the same, which allow a consumer to generate individualistic biological responses/effects. More specifically, a nutrient system for generating individualiz... | 12/14/2010 |
| 7785619 | Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens Individualized responsive dosing pharmanutrient systems, compositions, methods of dosing, and processes of producing the same, which allow a consumer to generate individualistic biological responses/effects. More specifically, a pharmanutrient system for generating ... | 08/31/2010 |
| 7727546 | Nutrient system for individualized responsive dosing regimens Individualized responsive dosing dietary supplement systems, compositions, methods of dosing, and processes of producing the same, which allow a consumer to generate individualistic biological responses/effects. More specifically, a dietary supplement system for gen... | 06/01/2010 |
| 7651698 | Prolonged release bioadhesive therapeutic systems The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active principle dissolution test of more than 70% over 8 hours and to a method for its preparation. This bioadhesive therapeu... | 01/26/2010 |
| 7632517 | Buccal, polar and non-polar spray containing zolpidem Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide zolpidem for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I... | 12/15/2009 |
| 7579019 | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon ... | 08/25/2009 |
| 7507420 | Peptidyl prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 03/24/2009 |
| 7491406 | Fast dissolving orally consumable films Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, met... | 02/17/2009 |
| 7407669 | Fast dissolving orally consumable films Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, met... | 08/05/2008 |
| 7399466 | Method and compositions for promoting osteogenesis The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require osteogenesis. Osteocalcin is an endogenous inhibitor of the PHEX activi... | 07/15/2008 |
| 7393544 | Dispersion for pulmonary delivery of a bioactive agent Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between ... | 07/01/2008 |
| 7357255 | Packaged supply of individual doses of a personal care product A packaged supply of individual doses of a personal care product, e.g., strips of a water-soluble film that contains a pharmaceutically active material, comprises the combination of a) a tray; b) a plurality of substantially identical packets uniformly stacked in th... | 04/15/2008 |
| 7351425 | Confectionary product containing functional ingredients A gum, lollipop and lozenge having at least two separate components, with at least one of such components containing amounts of herbal, medicinal and/or mineral elements or combinations thereof. ... | 04/01/2008 |
| 7347985 | Breath freshening and oral cleansing product with magnolia bark extract A pullulan-free edible film composition for oral cleansing, breath freshening, and anti-microbial benefits includes a film forming agent and Magnolia Bark Extract. In a treatment process, an effective amount of Magnolia Bark Extract is delivered to the oral cavity b... | 03/25/2008 |
| 7338664 | Color changing matrix as wear indicator A sustained-release matrix for dental application includes either an anti-microbial agent or a colorant that is released from the matrix when the matrix contacts water. The preferred matrices include a water-soluble polymer and a water-insoluble support resin. ... | 03/04/2008 |
| 7332230 | Multilayer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients A multilayer preparation in the form of films of hydrophilic polymers for rapid release of substances present in the film layers into liquid surroundings is characterized in that adjacent layers differ from one another in that in each case one layer is soluble in a ... | 02/19/2008 |
| 7332177 | Method and formulation for treating resistance to antihypertensives and related conditions A method for the prevention or treatment of symptoms of hypertension in a patient who is resistant to antihypertensive effects of an antihypertensive compound administered in the absence of melatonin comprises administering to said patient melatonin in an amount eff... | 02/19/2008 |
| 7323160 | Method of treating a patient's teeth using fluoride releasing glass composition A method of treating sensitive teeth includes (1) attaching a fluoride releasing glass composition to a person's tooth, and (2) allowing fluoride to be slowly released over time in order to reduce chronic and/or acute tooth sensitivity. A preferred glass composition... | 01/29/2008 |
| 7323161 | Patch for tooth whitening The patch for tooth whitening of the present invention includes a tooth-adhering layer (1) containing erodible polymer complexes formed by hydrogen bonding of a polymer with a carboxyl group (—COOH) and a polymer with a carbonyl group (—C═O) or ether gr... | 01/29/2008 |
| 7316821 | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated ... | 01/08/2008 |
| 7314862 | Antitumor agent The present invention relates to an antitumor agent containing a histone deacetylase inhibitor and a topoisomerase II inhibitor in combination. This combination has been found to exhibit a synergistic anticancer or antitumor effect compared to administration of eith... | 01/01/2008 |
| 7303756 | Multiphase system The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change in ambient conditions alters the viscosity of the carrier phase. The i... | 12/04/2007 |
| 7304030 | Matrix protein composition for dentin regeneration The present invention relates to the surprising finding that enamel matrix, enamel matrix derivatives and/or enamel matrix proteins induce dentin regeneration. The invention thus relates to the use of a preparation of an active enamel substance for the preparation o... | 12/04/2007 |
| 7303768 | Preparation of aqueous clear solution dosage forms with bile acids Compositions for pharmaceutical and other uses comprising clear aqueous solutions of bile acids which do not form any detectable precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the inve... | 12/04/2007 |
| 7282217 | Rapidly disintegrable tablets The invention provides a rapidly disintegrating tablet comprising an active ingredient, a water soluble, directly compressible carbohydrate, and a water soluble, directly compressible filler. Also provided is a method of producing a rapidly disintegrating tablet, wh... | 10/16/2007 |
| 7273887 | Topical anesthetic formulation The topical anesthetic formulation of the present invention is typically a solution that preferably includes lidocaine, USP as the active anesthetic ingredient with benzyl alcohol and isopropyl alcohol. This invention deals with problems commonly associated with top... | 09/25/2007 |
| 7267718 | Pullulan film compositions The invention concerns compositions based on pullulan and a setting system for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. T... | 09/11/2007 |
| 7255876 | Composition comprises sustained-release fine particles and manufacturing method thereof The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from th... | 08/14/2007 |
| 7241143 | Preloaded dental dam and method for gingival tissue retraction A method and a device for effecting the cordless retraction of the gingival sulcus tissue that includes a dam shaped to be fitted onto a tooth. The dam having a peripheral wall defining a well. The peripheral wall may be either pervious or impervious to light rays a... | 07/10/2007 |
| 7241746 | Method and composition for treating periodontal disease The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramici... | 07/10/2007 |
| 7241411 | Thin film strips A method of forming a thin film strip and thin film strips formed thereby where the method comprises coating a liner substrate with a wet slurry of film forming ingredients and other components and drying the wet slurry in a drying apparatus to form a film, measurin... | 07/10/2007 |
| 7235248 | Pharmaceutical compositions comprising cyclosporins Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva]2-Ciclosporin, in “microemulsion pre-concentrate” and microemulsion form. The compositions typically comprise (1.1) a C1-5alkyl or tetrahydrofurfuryl di- or part... | 06/26/2007 |
| 7232500 | Method and device for producing products in web form This invention pertains to methods and devices for producing products in web form. In particularly advantageous embodiments, the instant invention relates to methods and devices for forming films by coating a coating mass formed from organic raw materials in an aque... | 06/19/2007 |
| 7223416 | Topical composition A composition containing at least one NSAID formulated for topical administration to a mucous membrane and/or skin for prophylactic or symptomatic therapy. The composition may also contain an anti-irritant such as a non-nutritive sweetener, which improves compliance... | 05/29/2007 |
| 7223571 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glyco... | 05/29/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7214683 | Compositions of descarboethoxyloratadine Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. ... | 05/08/2007 |
| 7195483 | Method and device for the retraction and hemostasis of tissue during crown and bridge procedures A method and a device for effecting the cordless retraction of the gingival sulcus tissue (21) prior to the taking of an impression of a tooth (20) for making a crown or bridge which is attained by controlling any bleeding in the gingival sulcus area (... | 03/27/2007 |
