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| Number | Title | Issue Date |
| 8440215 | Absorbable polymer formulations A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectab... | 05/14/2013 |
| 8435552 | Collagen/hydroxyapatite composite scaffold, and process for the production thereof A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilizing the suspension until a desired final freezing temperature is reached to produce th... | 05/07/2013 |
| 8435550 | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a st... | 05/07/2013 |
| 8435551 | Cancellous construct with support ring for repair of osteochondral defects The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter ... | 05/07/2013 |
| 8435553 | Elastin stabilization of connective tissue A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protoc... | 05/07/2013 |
| 8431146 | Scaffold comprising co-precipitated Collgen and glycosaminoglycan for inhibiting adhesion of body tissue layers A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhes... | 04/30/2013 |
| 8431147 | Malleable implants containing demineralized bone matrix Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a p... | 04/30/2013 |
| 8425926 | Antimicrobial medical devices The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The ant... | 04/23/2013 |
| 8425927 | Compositions and methods for coating medical implants Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant. ... | 04/23/2013 |
| 8420110 | Drug coated expandable devices Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agen... | 04/16/2013 |
| 8420111 | Method and kit for reducing the symptoms of peripheral vascular disease A method for reducing the symptoms of peripheral vascular disease and for improving peripheral circulation wherein a progestin is administered to a subject in need thereof. ... | 04/16/2013 |
| 8414908 | Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo impla... | 04/09/2013 |
| 8414909 | Drug releasing coatings for medical devices The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part... | 04/09/2013 |
| 8414910 | Drug releasing coatings for medical devices The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodim... | 04/09/2013 |
| 8414907 | Coatings on medical implants to guide soft tissue healing Embodiments include coatings or surface treatments for medical instruments, devices, and/or implants that promote soft tissue healing. More particularly, embodiments relate to treating portions of instruments, devices, and implants where tissue healing is desired wi... | 04/09/2013 |
| 8409601 | Rapamycin coated expandable devices Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agen... | 04/02/2013 |
| 8409604 | Immobilized biologically active entities having a high degree of biological activity The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity. ... | 04/02/2013 |
| 8409603 | Compositions and methods for tissue engineering, tissue regeneration and wound healing In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel structure and an isolated polypeptide having the carboxy-terminal amino ac... | 04/02/2013 |
| 8409602 | Sealants for fetal membrane repair The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocom... | 04/02/2013 |
| 8409600 | Methods for prevention and/or treatment of capsular contracture Methods for prevention or treatment of capsular contracture following surgical implants and other fibrosis related conditions comprising applying a topical composition comprising a pharmaceutically acceptable keratolytic, a pharmaceutically acceptable protein denatu... | 04/02/2013 |
| 8404264 | Functionalizing implantable devices with a poly (diol citrate) polymer The present invention is directed to a novel poly (diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using implantable devices coated with citric acid copolymers or citric aci... | 03/26/2013 |
| 8399010 | Highly-mineralized osteogenic sponge compositions and uses thereof Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogen... | 03/19/2013 |
| 8399008 | System and method for attaching soft tissue to annodized metal implant One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said por... | 03/19/2013 |
| 8399009 | Bioceramic and biopolymer composite The invention provides a high performance porous bioceramic composite that has a high compression strength resulting from the ability to compression form a bioceramic precursor material and a pore forming agent under a high pressure load prior to sintering and/or re... | 03/19/2013 |
| 8399007 | Method for formulating a controlled-release pharmaceutical formulation Methods for making formulations of drugs and crystalline side chain polymers which formulations provide controlled and/or sustained release drug formulations. ... | 03/19/2013 |
| 8394399 | Drug-enhanced adhesion prevention The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Pemirolast, or an analog thereof, directly to t... | 03/12/2013 |
| 8394400 | Bulking agent The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformit... | 03/12/2013 |
| 8388994 | Fibrous non-woven polymeric material The present invention relates to biocompatible non-woven fibrous materials having a nano-micro topography and methods for producing such materials. The materials may be used to cover implantable medical devices and to fabricate a three-dimensional drug-eluting fibro... | 03/05/2013 |
| 8383143 | Antimicrobial medical devices containing chlorhexidine free base and salt The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, prefer... | 02/26/2013 |
| 8377461 | Multifunctional medical articles The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible a... | 02/19/2013 |
| 8372419 | Coated implants, their manufacturing and use thereof The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said soluti... | 02/12/2013 |
| 8372420 | Compositions and methods for coating medical implants Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant. ... | 02/12/2013 |
| 8372421 | Inhibition of mitogen-activated protein kinases in cardiovascular disease The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic material with a mitogen-activated protein kinase (MAPK) pathway inhibito... | 02/12/2013 |
| 8372423 | Implantable medical devices having microporous surface layers and method for reducing foreign body response to the same This disclosure provides implantable devices coated with microporous surface layers with macrotopographic features that improve bio-integration at the interface of the implantable devices and the surrounding tissue. ... | 02/12/2013 |
| 8372424 | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperat... | 02/12/2013 |
| 8372422 | Hydroxyapatite-targeting poly(ethylene glycol) and related polymers Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two te... | 02/12/2013 |
| 8367095 | Two-piece, internal-channel osmotic delivery system flow modulator An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The flu... | 02/05/2013 |
| 8367094 | Antimicrobial material and method for making the same This invention provides a modified catheter/indwelling device biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characte... | 02/05/2013 |
| 8367093 | Functionalized chemically inert polymers for coatings Provided herein are methods for functionalizing an polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer. ... | 02/05/2013 |
| 8367092 | Method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a rec... | 02/05/2013 |
