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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 8114428 | Methods for manufacturing a composition for treating bone and/or cartilage defects The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone a... | 02/14/2012 |
| 8114430 | Polyoxaester suspending vehicles for use with implantable delivery systems Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and a... | 02/14/2012 |
| 8114427 | Biologically active implants This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thi... | 02/14/2012 |
| 8114429 | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable... | 02/14/2012 |
| 8110208 | Hemostatic compositions for arresting blood flow from an open wound or surgical site A hemostatic composition for stopping or decreasing blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a mixture of a cationic polymer and a cation exchange material. In one embodiment, the composition comprises a ... | 02/07/2012 |
| 8106008 | Compositions and methods for arthrodetic procedures The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrod... | 01/31/2012 |
| 8101197 | Forming coils Coils, such as embolic coils, can include a substrate; and a porous material supported by the substrate. Related methods, devices, and compositions, can include: injecting a material into a container containing the coil; and forming the material into a coating that ... | 01/24/2012 |
| 8101198 | Osteogenic enhancer composition An osteogenic enhancer composition for bone and cartilage repair and methods of using the same are described. ... | 01/24/2012 |
| 8101196 | Polysaccharide biomaterials and methods of use thereof The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macro... | 01/24/2012 |
| 8097268 | Coatings for implantable medical devices Coatings for implantable medical devices comprising non-fouling moieties or polymers chemically bonded to the surface of the device via chelating structures, and methods of fabricating the coatings are disclosed. ... | 01/17/2012 |
| 8092818 | Medical devices having bioactive surfaces According to an aspect of the present invention, medical devices are provided, which contain (a) a substrate and (b) a polymeric region disposed over the substrate which contains at least one block copolymer. The block copolymer, in turn, contains at least two polym... | 01/10/2012 |
| 8092819 | Implantable medical device coated with a bioactive agent The present invention provides an implantable medical device comprising a bioactive agent and poly(alkyl cyanoacrylate) polymer. In one embodiment of the invention, the bioactive agent is a water-soluble material, such as an antisense agent. ... | 01/10/2012 |
| 8092820 | Dry hemostatic compositions and methods for their preparation Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextra... | 01/10/2012 |
| 8080259 | Sustained delivery of an active agent using an implantable system The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment i... | 12/20/2011 |
| 8075905 | Dental materials equipped with active anti-plaque substance(s) A process by means of which the colonization by plaque on dental materials can be permanently prevented or delayed without the product properties of the dental material being negatively influenced. The process involves equipping the dental material with anti-plaque ... | 12/13/2011 |
| 8075904 | High aspect ratio template and method for producing same for central and peripheral nerve repair Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompat... | 12/13/2011 |
| 8071537 | Implantable device for the sustained release of a polypeptide Described herein are implantable devices, formulations and methods of making implantable devices for the release of a polypeptide from an implantable device, and methods of use thereof. ... | 12/06/2011 |
| 8067020 | Sustained release formulation A composition comprises a protein, a polyol, and a metal. The protein is stabilized by the polyol and the metal, and is protected from denaturing when in contact with an organic solvent. The polyol may be a hydrocarbon containing two or more hydroxyl groups (—OH) ... | 11/29/2011 |
| 8067021 | Methods and compositions for delivery of growth factor to fibrous connective tissue The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of ... | 11/29/2011 |
| 8057813 | Multiple drug delivery from a balloon and a prosthesis Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as we... | 11/15/2011 |
| 8057814 | Drug delivery from stents An intravascular stent has a coat comprising a crosslinked amphiphilic polymer and a sparingly water soluble matrix metalloproteinase inhibitor (MMPI). Preferably the polymer is formed from 2-methacryloyloxy-2′-ethyltrimethylammonium phosphate inner salt, C4-... | 11/15/2011 |
| 8048857 | Flowable carrier compositions and methods of use A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calciu... | 11/01/2011 |
| 8048438 | Stable non- aqueous single phase viscous vehicles and formulations utilizing such vehicles This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperat... | 11/01/2011 |
| 8048437 | Medical device with surface coating comprising bioactive compound Coatings comprising protein resistant components and therapeutic components on medical devices are disclosed. The coatings act to down-regulate complement activation. Medical devices can be coated with these coatings to prevent side effects and improve patency. ... | 11/01/2011 |
| 8044026 | Composition for promoting cartilage formation or repair comprising a NELL gene product and method of treating cartilage-related conditions using such composition Provided herein are a composition for promoting cartilage formation or regeneration comprising a NELL gene product and a method of treating cartilage-related conditions using such a composition. ... | 10/25/2011 |
| 8034361 | Stent coatings incorporating nanoparticles Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings. ... | 10/11/2011 |
| 8029815 | Methods for treating or preventing restenosis and other vascular proliferative disorders Described herein is the use of ribonucleotide reductase inhibitors in the prevention or treatment of restenosis and other vascular proliferative disorders. ... | 10/04/2011 |
| 8017140 | Drug-delivery stent formulations for restenosis and vulnerable plaque Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque. ... | 09/13/2011 |
| 8017139 | Blend hydrogels and methods of making The present invention provides blend water-swellable materials and hydrogels suitable for use in biomedical or other applications. The blend water swellable materials and hydrogels have at least one hydrophilic polymer and at least one other polymer or oligomer havi... | 09/13/2011 |
| 8002813 | Volume maintaining osteoinductive/osteoconductive compositions An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing a... | 08/23/2011 |
| 7988986 | Implant filling material and method Compositions of cross-linked polyvinylpyrrolidone (PVP) are disclosed that are generally in the form of an elastic, hydrophilic, water-insoluble viscous cohesive mass of material that has many important medical uses including uses as a filler for implants. The prese... | 08/02/2011 |
| 7985414 | Polyurethanes for osteoimplants Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined... | 07/26/2011 |
| 7976859 | Implant filling material and method Compositions of cross-linked polyvinylpyrrolidone (PVP) are disclosed that are generally in the form of an elastic, hydrophilic, water-insoluble viscous cohesive mass of material that has many important medical uses including uses as a filler for implants. The prese... | 07/12/2011 |
| 7976858 | Drug delivery to a joint A method of intra-articular drug delivery may include selecting an attachment zone in a synovial joint; affixing a drug release device in the attachment zone, the drug release device comprising a base affixable in the attachment zone, a sustained-release drug carrie... | 07/12/2011 |
| 7972615 | Peptide compositions for coating metal medical devices with vancomycin The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecul... | 07/05/2011 |
| 7964206 | Porous medical device and method for its manufacture Porous bioabsorbable, bioactive and load-bearing composite medical device structure includes a plurality of regular textile planar layers (1a, 1b . . . ) formed of continuous bioabsorbable polymer matrix and bioceramic fibers acting as re... | 06/21/2011 |
| 7959938 | Polyoxaester suspending vehicles for use with implantable delivery systems Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and a... | 06/14/2011 |
| 7960335 | Octreotide implant having a release agent and uses thereof Methods, formulations and kits are described that allow for the controlled release of octreotide, e.g., octreotide acetate, in a subject. ... | 06/14/2011 |
| 7947299 | Compositions and techniques for localized therapy A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the ... | 05/24/2011 |
| 7947300 | Resorbable thin membranes Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The memb... | 05/24/2011 |
