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| Number | Title | Issue Date |
| 7666441 | Allergenic proteins and peptides from dog dander and uses therefor Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having... | 02/23/2010 |
| 7498038 | Chitin microparticles and their medical uses The present invention relates to chitin microparticles and their medical uses, in particular in the treatment of allergy, or the treatment of conditions that would benefit from an upregulation of the cell mediated immune system, or an up-regulation of natural killer... | 03/03/2009 |
| 7491405 | Antigenic protein originating in A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein;... | 02/17/2009 |
| 7425333 | Hypoallergenic allergy vaccines based on the timothy grass pollen allergen Phl p 7 The present invention pertains to polypeptides derived from the timothy grass pollen allergen Phl p 7. The polypeptides display reduced allergen activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccinatio... | 09/16/2008 |
| 7410654 | Pollen manufacturing method Pollen is washed and cleaned, crushed and sterilized. Pollen particles are filtered through a filter device and the particles of less than 50 μm of diameter are taken out. Then the pollen particles are thrown into electrolysis reducing water including active hydrog... | 08/12/2008 |
| 7407657 | T-cell epitope peptides The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen allergy with an overlap peptide covering the primary structure of the J... | 08/05/2008 |
| 7407944 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of... | 08/05/2008 |
| 7393542 | Remedies for allergic diseases using processed peanut seed coat An agent for treating or preventing allergic disease comprising, as an active ingredient, a treated product of peanut seed coats. ... | 07/01/2008 |
| 7384635 | Protein variants of naturally occurring allergens The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants. ... | 06/10/2008 |
| 7348009 | Recombinant allergen with reduced enzymatic activity The present invention provides a novel treatment for allergy comprising a recombinant allergen with reduced enzymatic activity, thereby reducing the potential for an allergic response upon contact with a wild-type allergen. ... | 03/25/2008 |
| 7306782 | Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hy... | 12/11/2007 |
| 7303756 | Multiphase system The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change in ambient conditions alters the viscosity of the carrier phase. The i... | 12/04/2007 |
| 7279163 | Water-in-oil emulsion vaccines Oil-in-Water emulsion vaccines induce higher biliary IgA responses which decrease mucosal/internal organ invasion and fecal shedding, increase specific activity of serum IgG subpopulations, and increase the relative avidity index of serum IgG subpopulations, resulti... | 10/09/2007 |
| 7279295 | Allergen The present invention relates to a novel allergen from timothy grass (Phleum pretense) pollen, Phl p11 as disclosed in SEQ ID NO:2, and use thereof as a reagent and in a diagnositic kit as well as for immunotherapy. ... | 10/09/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7241450 | DNA sequence and recombinant production of a Gramineae allergen The invention relates to the identification and characterization of a grass-pollen allergen, and to the recombinant DNA molecule encoding therefore, and to corresponding DNA and peptide sequences. ... | 07/10/2007 |
| 7235246 | Dermatomycosis vaccine The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity agains... | 06/26/2007 |
| 7214380 | Adjuvant therapy Methods are provided for the treatment of allergic and other immune disorders associated with overproduction of Th2 type cytokines by antigen specific T cells. Immunotherapy with adjuvants, as provided in the present invention, greatly inhibits the development of ai... | 05/08/2007 |
| 7208156 | Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are discl... | 04/24/2007 |
| 7208155 | Agent for treating allergic or hypersensitivity condition The use of an agent in the manufacture of a medicament to affect an allergic condition and/or a hypersensitivity condition is described. The agent is capable of modulating a ganglioside associated activity. The agent is not coupled to an antigen. The modulation of t... | 04/24/2007 |
| 7166302 | Complexing agents for compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 01/23/2007 |
| 7166291 | Allergenic proteins and peptides from dog dander and uses therefor Isolated nucleic acids encoding allergens of Canis familiaris, Can fI or Can fII. are disclosed. A cDNA encoding a peptide having a Can fI activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Ca... | 01/23/2007 |
| 7163683 | Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are discl... | 01/16/2007 |
| 7128921 | Dermatophagoides proteins and fragments thereof The present invention relates to high molecular weight Dermatophagoides proteins, nucleic acid molecules encoding such proteins, and therapeutic and diagnostic reagents derived from such proteins. ... | 10/31/2006 |
| 7112333 | T cell epitopes of ryegrass pollen allergen The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a p... | 09/26/2006 |
| 7112329 | T cell epitope peptide The T-cell epitope site on a Japanese cypress (hinoki) pollen allergen molecule has been identified by stimulating a T-cell line established from a patient suffering from Japanese cypress pollen allergy with an overlap peptide covering the primary structure of the J... | 09/26/2006 |
| 7108858 | Non-anaphylactic forms of allergens and their use The present invention is drawn to an immunogen derived from a protein allergen, which is a) a non-anaphylactic immunogenic recombinant fragment of the protein allergen which contains an IgG epitope partly but not wholly overlapping an IgE epitope of the protein alle... | 09/19/2006 |
| 7094946 | Animal model for allergic disorders An animal suitable as a model for an allergic disorder, wherein the animal is an immuno-modulated animal which has been sensitized with an antigen under a specific pathogen free environment such that when the animal displays allergy symptoms caused by the antigen. | 08/22/2006 |
| 7090857 | Antigenic preparations The present invention relates to antigenic preparations comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, process for the preparation of these antigenic preparations, their use as pharmaceutical substances as wel... | 08/15/2006 |
| 7091192 | Linear cyclodextrin copolymers Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclode... | 08/15/2006 |
| 7074900 | Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin Thioredoxin, a small dithiol protein, is a specific reductant for allergenic proteins and particularly allergenic proteins present in pollen and animal and plant sources. All targeted proteins contain disulfide (S—S) bonds that are reduced to the sulfhydryl (SH) l... | 07/11/2006 |
| 7060274 | Receptor specific transepithelial transport of therapeutics The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to metho... | 06/13/2006 |
| 7055334 | Air-conditioning unit and air-conditioning apparatus incorporating same An indoor air-conditioning unit 10 which can effectively deactivate allergens includes an intake grill 11 for drawing in indoor air. Indoor heat exchangers 13, 14, and 15 exchange heat between air drawn in from the intake grill 11 ... | 06/06/2006 |
| 7048928 | Anti-allergic pharmaceutical composition containing at least one allergen and at least one antihistamine compound The present invention relates to an anti-allergic pharmaceutical composition containing at least two active agents chosen from among: (i) one allergen, (ii) one antihistamine compound, and (iii) one inhibitor of histamine synthesis. The active agents are associated ... | 05/23/2006 |
| 7029686 | Variants of Phleum pratense allergenic proteins Hypoallergenic variants of the major allergen Ph1 p 1 of Phleum pratense plants and their use in the therapy of the allergic diseases is disclosed. ... | 04/18/2006 |
| 7025972 | Allergen absorbent, blocking, and deactivating compositions and method An allergen and blocking sorbent for topical application to the skin comprising a surface-modified layered material, such as an intercalated clay, dispersed in a cosmetically acceptable solvent. The organic surface modifier is an organic molecule that contains a sub... | 04/11/2006 |
| 7025964 | Peptide-based immunotherapeutic agent A peptide-based immunotherapeutic agent effective for every allergy patient is provided. A reagent for typing HLA class II molecules of the patient to be used in selecting a peptide-based immunotherapeutic agent effective for every allergy patient is also provided. ... | 04/11/2006 |
| 7026128 | Allergenic proteins and peptides from dog dander and uses therefor Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having... | 04/11/2006 |
| 7018609 | Compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 03/28/2006 |
| 6994870 | Local nasal immunotherapy with allergen strip for allergic rhinitis A method and strip for treating allergen-induced airway inflammation. The method includes applying a nasal or skin strip containing a mixture of an allergen and a pharmaceutically acceptable carrier to an individual having allergen-induced airway inflammation in a m... | 02/07/2006 |