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| Number | Title | Issue Date |
| 8337865 | Modified flagellin improved toll-like receptor 5 stimulating activity Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agoni... | 12/25/2012 |
| 8337864 | Modified flagellin improved toll-like receptor 5 stimulating activity Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agoni... | 12/25/2012 |
| 8236327 | Modified flagellin improved toll-like receptor 5 stimulating activity Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agoni... | 08/07/2012 |
| 8039008 | Identification of residues critical for the function of the vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis Disclosed are Vibrio cholerae comprising a mutated transcriptional regulatory protein (ToxT) amino acid sequence, wherein the mutation results in a reduction in the expression of cholera toxin by the Vibrio cholerae. Also disclosed are Vibrio choler... | 10/18/2011 |
| 7871629 | Delivery of DNA vaccines into fish by immersion A method for immunizing fish against pathogenic infection is disclosed. More particularly, this invention provides a method of immunizing fish against bacterial and viral infection which comprises immersing the fish in a solution comprised of an effective amount of ... | 01/18/2011 |
| 7838016 | strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproc... | 11/23/2010 |
| 7438914 | Composition and method for enhancing immune response A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptide... | 10/21/2008 |
| 7422752 | Mutant forms of EtxB and CtxB and their use as carriers The present invention describes the use of a mutant form of EtxB or CtxB to deliver an agent to a target cell wherein the mutant has GM-1 binding activity; but wherein the mutant has a reduced immunogenic and immunomodulatory activity relative to the wild type form ... | 09/09/2008 |
| 7384639 | Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to... | 06/10/2008 |
| 7361355 | Mutant forms of cholera holotoxin as an adjuvant Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wi... | 04/22/2008 |
| 7332174 | Mutant forms of cholera holotoxin as an adjuvant Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response... | 02/19/2008 |
| 7285281 | Mutant forms of cholera holotoxin as an adjuvant Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wi... | 10/23/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7261899 | Method of producing thy A-strains of , such strains and their use A method of producing a thy A−strain of vibrio cholerae comprising the step of site-directed mutagenesis in the V. cholerae chromosome at the locus of the thy A gene SEQ ID NO: 1 of FIG. 1, is described. Particularly, a Δ thy A str... | 08/28/2007 |
| 7160549 | Methods for making compositions including gram negative microbial polypeptides The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative microbe, disrupting the microbe, solubilizing the disrupted microbe, and ... | 01/09/2007 |
| 7090856 | Anti-fouling exopolysaccharides isolated from cultures of and An anti-fouling agent derived by culturing Vibrio alginolyticus in a suitable aqueous solution as well as a newly isolated strain of V. alginolyticus (DSM 15590) for producing the anti-fouting agent. The anti-fouling agent can be used as a component to... | 08/15/2006 |
| 7090853 | Noscapine derivatives as adjuvant compositions and methods of use thereof An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines. ... | 08/15/2006 |
| 7070781 | Nontoxic mucosal adjuvant A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic mucosal adjuvant is a detoxified mutant of a bacterial ADP-ribosylating t... | 07/04/2006 |
| 7063852 | Hybrid LT-A/CT-B holotoxin for use as an adjuvant The present invention provides a novel composition which is a hybrid heat labile enterotoxin comprising the A-subunit of the heat labile toxin of Escherichia coli (LT-A) and the B-subunit of the cholera enterotoxin of Vibrio cholerae (CT-B). The hybrid... | 06/20/2006 |
| 7056521 | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT). ... | 06/06/2006 |
| 7041296 | Methods of treating inflammatory bowel disease using cholera toxin B subunit The present invention provides a method of treating or preventing inflammation in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. The present invention also provides a method of decreasing the activity of interferon... | 05/09/2006 |
| 7037499 | Adjuvant for transcutaneous immunization A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune re... | 05/02/2006 |
| 6913757 | Live, avirulent strain of V. anguillarum that protects fish against infection by virulent V. anguillarum and method of making the same The present invention comprises the identification, characterization and sequencing of a gene within the V. anguillarum genome, the mugA gene, a live, attenuated strain of V. anguillarum which comprises a mutated mugA gene, methods of making the strain... | 07/05/2005 |
| 6811787 | Over-expressing homologous antigen vaccine and a method of making the same This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering from disease caused by a pathogenic micro-organism. The vaccine is an ... | 11/02/2004 |
| 6733762 | Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner Methods of using Zot or zonulin as an antigen specific inhibitor of APC activity and lymphocyte proliferation, being primarily useful in the field of immunoregulation and immunotherapy as described. Specifically, Zot and zonulin inhibit antigen presenting cell-media... | 05/11/2004 |
| 6723323 | Vibrio Cholerae vaccine candidates and method of their constructing Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA mutant of Vibrio cholerae and the general methodol... | 04/20/2004 |
| 6613321 | Live vaccines against gram-negative pathogens, expressing heterologous O-antigens The present invention relates to live attenuated gram-negative vaccine carrier strains which are useful for expression and delivery of heterologous O-antigens (O-PS) from gram-negative pathogens. Said strains are deficient in the expression of homologous ... | 09/02/2003 |
| 6548287 | Non-pyrogenic bacterial strains and use of the same The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the... | 04/15/2003 |
| 6444210 | Bacterial and synthetic polysaccharide immunomodulators that enhance general immunity The present invention relates to the effects of bacterial polysaccharides on cell mediated immunity in animals. Polysaccharides of the present invention comprise the outer polysaccharides (OPS) located on bacterial cell membranes and other polysaccharides... | 09/03/2002 |
| 6440423 | Mutant enterotoxin effective as a non-toxic oral adjuvant Methods and compositions are provided herein for the se of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This enterotoxin is used in combination with an unrelated antigen to a... | 08/27/2002 |
| 6426075 | Protease-activatable pseudomonas exotoxin A-like proproteins This invention provides protease-activatable Pseudomonas exotoxin A-like ("PE-like") proproteins. The proproteins comprise (1) a cell recognition domain of between 10 and 1500 amino acids that binds to a cell surface receptor; (2) a modified PE translocat... | 07/30/2002 |
| 6395964 | Oral immunization with transgenic plants The oral antigens and adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents wh... | 05/28/2002 |
| 6290962 | Urease-based vaccine and treatment for helicobacter infection Method of eliciting in a mammalian host a protective immune response to Helicobacter infection and treatment of Helicobacter infection by administering to the host an immunogenically effective amount of a Helicobacter urease or urease subunits as antigen.... | 09/18/2001 |
| 6270777 | Conserved metalloprotease epitopes The present invention provides immunogenic compositions comprising peptides derived from the amino acid sequence of P. aeruginosa for protecting susceptible hosts against diseases caused by bacterial pathogens which secrete a zinc metalloprotease.... | 08/07/2001 |
| 6255097 | Two-phase system for the production and presentation of foreign antigens in hybrid live vaccines The present invention relates to a genetic engineering process for the optimal production and exposure to the immune system of additional antigen coded for by a live vaccine. The genetic engineering process is based on the use of spontaneous DNA reorganis... | 07/03/2001 |
| 6203799 | Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit V. cholerae vaccine strains which have a soft agar penetration-defective phenotype and methods for making such strains are described. Also described are methods for identifying new genes involved in V. cholerae motility and the cloning, identification, an... | 03/20/2001 |
| 6162433 | Non antibiotic selectable markers for live vaccines The invention relates to DNA constructs encoding a safe, selectable marker, other than an antibiotic resistance marker, vectors and/or cells including said constructs; and vaccines based on said constructs for use in animals and particularly humans. The s... | 12/19/2000 |
| 6149920 | Over-expressing homologous antigen vaccine and a method of making the same This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering from disease caused by a pathogenic micro-organism. The vac... | 11/21/2000 |
| 6149919 | Immunogenic detoxified mutants of cholera toxin and of the toxin LT, their preparation and their use for the preparation of vaccines An immunogenic detoxified protein comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding ... | 11/21/2000 |
| 6106843 | Process for the isolation of a nontoxinogenic vibrio cholerae strain and a process for preparing cholera vaccine from said vibrio cholerae strain A process for the isolation of nontoxinogenic V. cholerae strain and a process for preparing a cholera vaccine from said V. cholerae strain, said process comprising (a) isolating V. cholerae from the stool of a patient suffering from cholera by spreading ... | 08/22/2000 |
