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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 7404960 | Multivalent vaccine composition having increased stability of capsular polysaccharide A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more o-acetyl groups and which is not a... | 07/29/2008 |
| 7371390 | Vaccine against HBV and HPV Novel combined vaccine compositions are provided, comprising a hepatitis B viral antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, a herpes simplex viral antigen, a VZV antigen, a ... | 05/13/2008 |
| 7357936 | Adjuvant systems and vaccines The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting particle is essentially devoid of antigen. ... | 04/15/2008 |
| 7244422 | Vaccines containing ribavirin and methods of use thereof The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of Ribavirin as an adjuvant to a vaccine protocol and compositions having Ribav... | 07/17/2007 |
| 7244715 | Vaccines containing ribavirin and methods of use thereof Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope presen... | 07/17/2007 |
| 7217784 | VP1 of foot-and-mouth disease virus A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1 protein of a foot-and-mouth disease virus. Also disclosed are a vacc... | 05/15/2007 |
| 7048931 | Compositions and methods for the therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a t... | 05/23/2006 |
| 7029678 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses. ... | 04/18/2006 |
| 6951752 | Method for large scale production of virus antigen The present invention provides improved methods of production of viral antigen on a culture of adherent cells bound to a microcarrier, wherein the methods provide for increased viral antigen yield per culture medium volume. The invention is also directed to a cell c... | 10/04/2005 |
| 6913923 | Virus envelope vector for gene transfer A gene transfer vector is prepared by introducing an exogenous gene into an inactivated virus envelope, through a freezing and thawing treatment or mixing with a detergent. There are also provided a pharmaceutical composition for gene therapy containing this gene tr... | 07/05/2005 |
| 6893644 | Hepatitis vaccines containing 3-O-deacylated monophoshoryl lipid A A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid. A ... | 05/17/2005 |
| 6884422 | Freeze-dried hepatitis A attenuated live vaccine and its stabilizer The present invention relates to hepatitis A vaccine, especially to a lyophilized attenuated hepatitis A vaccine which can be stored at ambient temperature for extended periods of time, and to a method for producing the same. The present invention further relates to... | 04/26/2005 |
| 6855535 | Method of large scale production of Hepatitis A virus The present invention provides methods of large scale production of Hepatitis A Virus (HAV) on VERO cells bound to microcarrier. The invention also provides for methods of isolation of HAV from the cell culture supernatant of HAV infected VERO cells. ... | 02/15/2005 |
| 6825027 | Method of production of purified hepatitis a virus particles and vaccine preparation The present invention provides methods of purification of Hepatitis A Virus from the supernatant of an infected cell culture and production of a preparation of purified HAV antigen. The present invention is also directed to an HAV vaccine composition comprising a pr... | 11/30/2004 |
| 6756040 | Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also relates to a multivalent vaccines, that is a vaccine for the amelioratio... | 06/29/2004 |
| 6699480 | Vaccine compositions The invention provides the use of Hepatitis A virus capsid, or a mucosally immunogenic fragment or epitope thereof, for the manufacture of a mucosal vaccine composition for administration to a mucosal surface of a patient to induce production of serum Imm... | 03/02/2004 |
| 6680060 | Hepatitus A virus vaccines A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine ... | 01/20/2004 |
| 6623739 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent inducers of a range of immune responses.... | 09/23/2003 |
| 6620414 | Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination... | 09/16/2003 |
| 6565849 | Methods of enhancing activity of vaccines and vaccine compositions Disclosed are methods for vaccine priming, using co-treatment, at a temporally similar or at a previous time, with a priming antibody capable of priming, or enhancing, or potentiating the effects of a vaccine, or vaccine composition. Also disclosed are me... | 05/20/2003 |
| 6562350 | Combined vaccine against both HAV and measles virus and method of producing it A combined hepatitis A-measles live vaccine, its lyophilized formulations with enhanced storage stability and methods of preparing the same by mixing the viral stocks of hepatitis A virus and measles virus or by propagating the two viruses on same diploid... | 05/13/2003 |
| 6531313 | Invasive bacterial vectors for expressing alphavirus replicons The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to be expressed in the animal or the animal cells. The bacteri... | 03/11/2003 |
| 6488934 | Hepatitis B vaccine A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3 de-O-acylated monophosphoryl lipid A.... | 12/03/2002 |
| 6451320 | Combined hepatitis and herpesvirus antigen compositions Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in addition one or more of the following: an EBV antigen, a hepatit... | 09/17/2002 |
| 6440718 | Method for producing non-infectious recombinant picornavirus particles The invention relates to a process for recombinantly preparing picornavirus particles, in particular hepatitis A virus particles, their precursors and particles which are derived therefrom, with a structural protein precursor molecule (P1-2A or P1) and th... | 08/27/2002 |
| 6423318 | Hepatitis A virus vaccines A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine ... | 07/23/2002 |
| 6368602 | Mucosal immunization against hepatitis A virus (HAV) through rectal administration of HAV vaccine A method for administering the HAV vaccine to a subject by absorption through a mucosal tissue, particularly through the mucosa of the rectum. The method of the present invention enables the HAV vaccine to be administered to the subject rectally, for exam... | 04/09/2002 |
| 6280734 | Simian-human HAV having a chimeric 2C protein The present invention discloses simian-human hepatitis A virus chimeric genomes which encode a hepatitis A virus having a chimeric 2C protein. The invention further discloses the use of these viruses or the nucleic acid sequence encoding them as vaccines.... | 08/28/2001 |
| 6194210 | Hepatitis A virus culture process A microcarrier based process to produce viral vaccines, of which one example is hepatitis A virus (HAV), is composed of an aggregated microcarrier system of glass coated polystyrene microcarriers and MRC-5 cells which creates a stable environment for the ... | 02/27/2001 |
| 6180110 | Attenuated hepatitis a virus vaccine which grows in MRC-5 cells A live hepatitis A virus (HAV) adapted to grow in MRC-5 cells is described, the HAV preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation. Methods for adapting HAV to grow in MRC-5... | 01/30/2001 |
| 6149911 | Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration, characterized in that the said antigen or hapten is couple... | 11/21/2000 |
| 6146632 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of a range of immune responses.... | 11/14/2000 |
| 6146643 | Human/simian chimeric hepatitis A virus vaccine The present invention relates, in general, to a substantially pure preparation of the simian hepatitis A viral isolate AGM-27; a substantially pure preparation of the genomic DNA of simian hepatitis A viral isolate AGM-27; a pharmaceutical composition com... | 11/14/2000 |
| 6136322 | Hepatitis A virus deletion mutants and vaccine formulations containing the same Disclosed are live hepatitis A virus deletion mutants having a deletion mutation in the 5' nontranslated region of the viral genome. The deletion mutation may be selected from the group consisting of (a) pY1 deletion mutations that cause the virus to reta... | 10/24/2000 |
| 6129922 | Methods for adjuvant free hepatitis A virus vaccination The invention provides the use of Hepatitis A virus capsid, or a mucosally immunogenic fragment or epitope thereof, for the manufacture of a mucosal vaccine composition for administration to a mucosal surface of a patient to induce production of serum Imm... | 10/10/2000 |
| 6117449 | Method for inducing a systemic immune response to a hepatitis antigen A method is provided for inducing a systemic immune response to an antigen selected from hepatitis B and hepatitis C antigens in a mammal. The method comprises orally administering lyophilized multilamellar liposomes containing the antigen. The liposomes ... | 09/12/2000 |
| 6113912 | Hepatitis A virus vaccines A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine ... | 09/05/2000 |
| 6063380 | Enhanced immunogenic vaccine Vaccines, composed of antigens absorbed on alum or formulated in an alum-containing composition, have enhanced immunogenicity over existing vaccines. The vaccines of the invention are characterized by their combination with 2-120 μg per kg or 0.1 to 6 mg... | 05/16/2000 |
| 6027730 | Herpes simplex vaccine comprising HSV glycoprotein GD and 3 deacylated monophosphoryl lipid A Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.... | 02/22/2000 |
| 6020167 | Composition used as a therapeutic agent against chronic viral hepatic diseases A combination, comprising at least one polypeptide sequence, mediating the antigenicity of one or more epitopes, and a carrier, capable of presenting this/these polypeptide sequence(s), which are useful for the production of a medicament for the treatment... | 02/01/2000 |
