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| Number | Title | Issue Date |
| 8088392 | Capsid proteins and uses therefore The present invention provides methods for the use of viral capsid proteins and chaperone proteins to produce immunogenic macro-molecular structures as antigen carrier to carry desired epitopes or antigens, for enhancing the immunogenicity of the carried epitopes or... | 01/03/2012 |
| 8084039 | Methods and compositions for live attenuated viruses Embodiments herein relate to compositions of and methods for live viruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated viruses and compositions to reduce inactivation and/or degradation o... | 12/27/2011 |
| 8062642 | Production of papillomavirus capsid protein and virus-like particles The present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the protein in the cell. In another aspect of the invention, it has ... | 11/22/2011 |
| 8039001 | Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection Embodiments of the present invention provide compositions including a complexes of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. Other embodiments also provide complexes comprising chimeras of p... | 10/18/2011 |
| 8025888 | PCV2 immunogenic compositions and methods of producing such compositions An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells containe... | 09/27/2011 |
| 7976849 | Hepatitis-C virus testing New styles of hepatitis C virus (HCV), referred to as HCV-3 and HCV-4, have been identified and sequenced. Antigenic regions of HCV-2, HCV-3 and HCV-4 polypeptides have been identified. Immunoassays for HCV and antibodies thereto are described, which allow more comp... | 07/12/2011 |
| 7976848 | Optimized expression of HPV 58 L1 in yeast Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic mole... | 07/12/2011 |
| 7959928 | VLP-antigen conjugates and their uses as vaccines The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly pro... | 06/14/2011 |
| 7955603 | Norovirus vaccine formulations The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs,... | 06/07/2011 |
| 7947286 | Drosophila cell lines producing recombinant secretable filovirus surface glycoproteins lacking the membrane spanning domain Filovirus subunit protein immunogens are produced using a recombinant expression system and combined with one or more adjuvants in immunogenic formulations. The subunit proteins include GP95, GP-FL, VP40, VP24, and NP derived from Ebola Virus and Marburg Virus. Adju... | 05/24/2011 |
| 7947287 | Peptides for the treatment of cancer associated with the human papilloma virus (HPV) and other epithelial tumors This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides who... | 05/24/2011 |
| 7939082 | Papilloma virus vaccine A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections caused by papilloma virus. The method includes an initial step of constructing one or more recombinant ... | 05/10/2011 |
| 7910111 | Inhibitors of N-ethylmaleimide sensitive factor Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptid... | 03/22/2011 |
| 7897155 | Method for producing yeast expressed HPV types 6 and 16 capsid proteins Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLP... | 03/01/2011 |
| 7879337 | Mutant porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus which has been modified such that the conserved cysteine in the E protein has been deleted or changed to a non-cysteine residue and polynucleotides that encode it. Vaccines comprising the genetically m... | 02/01/2011 |
| 7858098 | Vaccine This invention pertains to methods for treating infections caused by human papillomaviruses. It has been determined that immunization with HPV16 and HPV 18 virus like particles provides cross-protection against other HPV types. ... | 12/28/2010 |
| 7842298 | Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products suc... | 11/30/2010 |
| 7829100 | Pharmaceutical composition having modified carrier A composition comprising: (a) one to three bioactive agents; and (b) a modified liquid vehicle; wherein immediately after manufacture of the composition, said composition can be administered to a host such that the one to three bi... | 11/09/2010 |
| 7829101 | PCV2 immunogenic compositions and methods of producing such compositions An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells containe... | 11/09/2010 |
| 7824689 | Chicken astrovirus type 2 The present invention provides a new chicken astrovirus (CAstV). This chicken astrovirus (CAstV-2) is immunologically distinct from known avian astroviruses and can be used to prepare vaccines. ... | 11/02/2010 |
| 7815914 | Methods for the treatment of cellular proliferative disorders The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive ras-MAP signaling. The invention also pertains to methods using reovirus for the treatment of cellular proliferative disorders, and pa... | 10/19/2010 |
| 7815915 | Mixture of human papillomavirus virus-like particles The present invention relates to a vaccine composition comprising VLPs containing L1 proteins or functional L1 protein derivatives from HPV 16, HPV 18, HPV 31 and HPV 45 genotypes. ... | 10/19/2010 |
| 7763259 | Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection This invention provides compositions including a chimera of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. The present invention also provides complexes comprising chimeras of papillomavirus L2 p... | 07/27/2010 |
| 7758866 | Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52 An immunogenic composition and methods for producing said composition, the composition comprising VLPs from HPV 16 and 18 and at least one other HPV cancer type, the other cancer type being selected from the list consisting of HPV types 31, 45 and 52, wherein the do... | 07/20/2010 |
| 7740865 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods f... | 06/22/2010 |
| 7740866 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods f... | 06/22/2010 |
| 7722883 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provi... | 05/25/2010 |
| 7709006 | Hepatitis-C virus testing New styles of hepatitis C virus (HCV), referred to as HCV-3 and HCV-4, have been identified and sequenced. Antigenic regions of HCV-2, HCV-3 and HCV-4 polypeptides have been identified. Immunoassays for HCV and antibodies thereto are described, which allow more comp... | 05/04/2010 |
| 7691389 | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encode... | 04/06/2010 |
| 7682618 | Generation of virus-like particles and use as panfilovirus vaccine In this application are described filovirus-like particles for both Ebola and Marburg and their use as a diagnostic and therapeutic agent as well as a filovirus vaccine. Also described is the association of Ebola and Marburg with lipid rafts during assembly and budd... | 03/23/2010 |
| 7674467 | bacteriophage and uses thereof The present invention is directed to isolated Salmonella bacteriophage, and methods of using Salmonella bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Salmonella. ... | 03/09/2010 |
| 7625567 | Induction of immune responses to isoaspartyl-modified antigens The present invention is directed to a method of enhancing the immune response of a patient relative to the normal immune response, by administering isoaspartyl-modified proteins, peptides, or cells, to a patient. The present invention is also directed to vaccines c... | 12/01/2009 |
| 7625568 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods f... | 12/01/2009 |
| 7622125 | Polycistronic HIV vector constructs The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions ... | 11/24/2009 |
| 7622126 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provi... | 11/24/2009 |
| 7618641 | Functionally reconstituted viral membranes containing adjuvant Vaccines directed against antigens such as membrane proteins from pathogens or tumor cells are disclosed. Also described are methods of forming reconstituted viral membranes, with membrane fusion activity, which are lipid bilayer membranes preferably containing natu... | 11/17/2009 |
| 7611718 | Attenuation of cytomegalovirus virulence A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes. ... | 11/03/2009 |
| 7611717 | Identifying virally infected and vaccinated organisms This document provides methods and materials related to assessing organisms for the presence or absence of anti-virus antibodies. For example, this document provides methods and materials that can be used to determine whether or not an organism (e.g., a member of a ... | 11/03/2009 |
| 7608272 | Methods and compositions for vaccination of animals with PRRSV antigens with improved immunogenicity Pigs challenged with hypoglycosylated variants of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) major surface protein GP5 exhibited increased production of PRRSV-neutralizing antibodies relative to the levels of neutralizing antibodies produced by pigs... | 10/27/2009 |
| 7579007 | Production of “biological carriers” for induction of immune responses and inhibition of viral replication This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus particles that have been specifically modified to give biological prop... | 08/25/2009 |
