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| Number | Title | Issue Date |
| 7674467 | bacteriophage and uses thereof The present invention is directed to isolated Salmonella bacteriophage, and methods of using Salmonella bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Salmonella. ... | 03/09/2010 |
| 7625567 | Induction of immune responses to isoaspartyl-modified antigens The present invention is directed to a method of enhancing the immune response of a patient relative to the normal immune response, by administering isoaspartyl-modified proteins, peptides, or cells, to a patient. The present invention is also directed to vaccines c... | 12/01/2009 |
| 7625568 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods f... | 12/01/2009 |
| 7622126 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provi... | 11/24/2009 |
| 7622125 | Polycistronic HIV vector constructs The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions ... | 11/24/2009 |
| 7618641 | Functionally reconstituted viral membranes containing adjuvant Vaccines directed against antigens such as membrane proteins from pathogens or tumor cells are disclosed. Also described are methods of forming reconstituted viral membranes, with membrane fusion activity, which are lipid bilayer membranes preferably containing natu... | 11/17/2009 |
| 7611717 | Identifying virally infected and vaccinated organisms This document provides methods and materials related to assessing organisms for the presence or absence of anti-virus antibodies. For example, this document provides methods and materials that can be used to determine whether or not an organism (e.g., a member of a ... | 11/03/2009 |
| 7611718 | Attenuation of cytomegalovirus virulence A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes. ... | 11/03/2009 |
| 7608272 | Methods and compositions for vaccination of animals with PRRSV antigens with improved immunogenicity Pigs challenged with hypoglycosylated variants of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) major surface protein GP5 exhibited increased production of PRRSV-neutralizing antibodies relative to the levels of neutralizing antibodies produced by pigs... | 10/27/2009 |
| 7579007 | Production of “biological carriers” for induction of immune responses and inhibition of viral replication This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus particles that have been specifically modified to give biological prop... | 08/25/2009 |
| 7550149 | Attenuation of cytomegalovirus virulence A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes. ... | 06/23/2009 |
| 7544362 | N protein mutants of porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified virus and polynucleotides are also provided. ... | 06/09/2009 |
| 7537770 | Attenuation of cytomegalovirus virulence A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes. ... | 05/26/2009 |
| 7510718 | Expression vectors and uses thereof The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing the vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics containing the vectors, and to therapeutic uses of the vectors. The nov... | 03/31/2009 |
| 7498036 | Optimized expression of HPV 58 L1 in yeast Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic mole... | 03/03/2009 |
| 7494658 | Papilloma virus truncated L1 protein and fusion protein constructs Vaccine formulations comprising, viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed. ... | 02/24/2009 |
| 7482015 | Optimized expression of HPV 45 L1 in yeast Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The syntheti... | 01/27/2009 |
| 7476389 | Papillomavirus vaccines A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in related to infections caused by papilloma virus. The method includes an initial step of constructing one or more recombinant D... | 01/13/2009 |
| 7468186 | Polyomavirus cellular epitopes and uses therefor The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Preferred peptides correspond to amino ac... | 12/23/2008 |
| 7465455 | Fusion protein of porcine reproductive and respiratory syndrome virus as PRRS vaccine A fusion protein of porcine reproductive and respiratory syndrome virus (PRRSV) for PRRSV vaccine. The fusion protein includes: (a) a Pseudomoitas Exoloxin A (PE) peptide that comprises a binding domain and a translocating domain; (b) a peptide fragment that contain... | 12/16/2008 |
| 7462356 | Chimeric papillomavirus-like particles The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and related synthetic DNA molecules, host cells, methods and vaccines. ... | 12/09/2008 |
| 7449190 | Assays for assembly of Ebola virus nucleocapsids The present invention relates to assays for the identification of compounds that inhibit assembly of NP, VP35, and VP24, or inhibit the glycosylation of NP, required for nucleocapsid formation, for use as anti-viral agents. The invention also relates to assays for t... | 11/11/2008 |
| 7445786 | Diagnosing and protecting against tursiops truncatus papillomavirus Composition for conferring protection against Tursiops truncatus papillomavirus (TtPV) infection in a subject includes a virus-like particle assembled from at least one type of TtPV L1 protein. Methods for protecting a subject against TtPV infection include a... | 11/04/2008 |
| 7442378 | Attenuated circovirus An isolated attenuated circovirus having a mutation in viral nucleic acid encoding viral protein 2 (VP2). The attenuated circovirus is particularly suitable for use in conferring immunity in an animal, particularly birds. ... | 10/28/2008 |
| 7442525 | Method for expressing HIV polypeptides Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 10/28/2008 |
| 7431931 | Compositions and method for preventing reactogenicity associated with administration of immunogenic live rotavirus compositions The present invention provides compositions for making a medicament and methods for the administration of a vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human x rhesus reassortant rotavirus compositions were... | 10/07/2008 |
| 7431932 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 10/07/2008 |
| 7431930 | Infectious bursal disease virus (IBDV) mutant expressing virus neutralising epitopes specific for classic-and variant IBDV strains The present invention provides a classic IBDV mutant that additionally comprises virus neutralising epitopes 67 (specific for variant-E IBDV). ... | 10/07/2008 |
| 7425336 | Canine influenza vaccines The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza ... | 09/16/2008 |
| 7422751 | Epstein-barr-virus-specific immunization The invention provides materials and methods for using EBV EBNA2 peptide epitopes to treat and/or prevent post-transplant lymphoproliferative disorders (PTLD). The invention also provides compositions and articles of manufacture containing EBNA2 peptide epitopes tha... | 09/09/2008 |
| 7423138 | Compositions and methods for treating papillomavirus-infected cells By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, includin... | 09/09/2008 |
| 7416732 | Papilloma virus-like particles, fusion proteins as well as processes for their production The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus p... | 08/26/2008 |
| 7413741 | HCV E1 comprising specific disulfide bridges The invention relates to recombinantly or synthetically produced HCV E1 envelope proteins or parts thereof comprising disulfides between specific cysteine residues. The invention further relates to viral-like particles and compositions comprising said HCV E1 envelop... | 08/19/2008 |
| 7410643 | Materials and methods relating to fusion proteins for inducing an immune response A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein, said fusion protein comprising said antigen and an adjuvant sequence d... | 08/12/2008 |
| 7410642 | Assays and therapies for latent viral infection Compositions that bind viral proteins that are specifically expressed during the latent stage of the viral life cycle are disclosed. These compositions bind the latent viral proteins while the viral proteins are expressed in their cellular host, and provide a means ... | 08/12/2008 |
| 7411058 | Cold-adapted equine influenza viruses The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at ... | 08/12/2008 |
| 7407944 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of... | 08/05/2008 |
| 7407662 | Modified viral particles with immunogenic properties and reduced lipid content The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employ... | 08/05/2008 |
| 7399477 | Cold-adapted equine influenza viruses The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at ... | 07/15/2008 |
| 7399473 | Virus coat protein/receptor chimeras and method of use The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charac... | 07/15/2008 |