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| Number | Title | Issue Date |
| 8435949 | Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using a pheromone, a luteinizing hormone (LH) and/or a human chorionic gonadotrophin (hCG). The method can be practiced in vivo to obtain more neural stem cells in situ... | 05/07/2013 |
| 8409586 | Stable liquid formulation of human growth hormone Disclosed herein is a stable liquid formulation comprising human growth hormone; L-lysine, L-arginine or polyethylene glycol 300; and poly(oxyethylene) poly(oxypropylene) copolymer, polyethylene glycol-15 polyoxystearate or polyethylene glycol-35 castor oil. ... | 04/02/2013 |
| 8389473 | Treatment of cardiac arrhythmias Compositions of the invention, including compounds that bind to a receptor for a glucagon-like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an exendin, or an agonist, an analog (preferably an agonist analog), a derivative, or a variant of any of aforem... | 03/05/2013 |
| 8389475 | Relaxin analogs Human relaxin analogs, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. ... | 03/05/2013 |
| 8383130 | Partial peptide of lacritin The invention provides a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, which is a particular partial sequence of lacritin, and having an amino acid length of not more than 70 residues. The polypeptide of the invention can promote adhesion between a... | 02/26/2013 |
| 8367073 | Chloramphenicol acetyl transferase (CAT)-defective somatostatin fusion protein and uses thereof Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition, low cost adjuvants for enhanced immunogenic response are provided. Vac... | 02/05/2013 |
| 8338374 | Stable growth hormone liquid formulation The present invention is directed to stable liquid growth hormone formulations that remain stable after physical agitation, and after exposure to one or more freeze-thaw events. Formulations of the present invention can be stored long term at a variety of temperatur... | 12/25/2012 |
| 8333974 | Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents The present invention provides effective dosing regimes for neural stem cell proliferating agents, kits containing effective dosing regimes for neural stem cell proliferating agents, and uses thereof. In particular, neural stem cell proliferating agents, such as hCG... | 12/18/2012 |
| 8329191 | Three-branched polyethylene glycol-G-CSF conjugate The present invention relates to three-branched PEG-G-CSF conjugate of general formula (1) in which the bonding ratio of three-branched polyethylene glycol (PEG) and G-CSF is 1:1 (mol/mol), wherein PEG has an average molecular weight of from 200 to 45,000 daltons; a... | 12/11/2012 |
| 8252746 | Anti-angiogenic agents and methods of their use The present invention relates to the use of sFRP-4 and functional variants thereof as anti-angiogenic agents. It relates to methods of treatment and screening methods using sFRP-4 and functional variants thereof. Further, it relates to compositions, and in particula... | 08/28/2012 |
| 8236323 | Method to treat inflammation The present invention relates generally to the fields of pharmacology, and particularly to a method for treating inflammation, particularly inflammation of the respiratory system. The invention provides a method to reduce or ameliorate inflammation, by administering... | 08/07/2012 |
| 8206722 | Somatostatin receptor antagonists and glucose control or hypoglycemia The present disclosure provides methods and uses for controlling tight blood glucose levels in a subject comprising administering an effective amount of a somatostatin inhibitor. The present disclosure provides methods and uses for treating or preventing hypoglycemi... | 06/26/2012 |
| 8187608 | Treatment of Fibrosis related disorders The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are p... | 05/29/2012 |
| 8178107 | Method of treatment of thrombocytopenia or risk thereof using MPL ligand (thrombopoietin), variants, and fragments thereof Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant or synthetic methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and m... | 05/15/2012 |
| 8178108 | Methods for expression and purification of recombinant human growth hormone The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encod... | 05/15/2012 |
| 8178109 | Compositions and methods of use for MGD-CSF in disease treatment Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure... | 05/15/2012 |
| 8168588 | Compositions comprising FGF-9 and betacellulin and methods for treating cardiac conditions Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby... | 05/01/2012 |
| 8168199 | Dipeptidyl peptidase IV inhibitors for the treatment of schizophrenia and depression A method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable DP IV inhibitor caus... | 05/01/2012 |
| 8163695 | Formulations of human growth hormone comprising a non-naturally encoded amino acid Formulations of modified human growth hormone polypeptides are provided. ... | 04/24/2012 |
| 8158582 | Methods for treatment of insulin-like growth factor-1 deficiency The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having an endocrine disorder characterized by partial endogenous growth hormone activity or signaling. Th... | 04/17/2012 |
| 8147844 | ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using ligand Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication, differentiation or maturation of blood cells, especially megakar... | 04/03/2012 |
| 8124099 | Soluble CD83 proteins and use thereof for the treatment and prevention of a disease or medical condition caused by dysfunction or undesired function of a cellular immune response involving T cells The present invention provides for the use of soluble forms of CD83 and nucleic acids encoding them for the treatment of diseases caused by the dysfunction or undesired function of a cellular immune response involving T cells. The invention moreover provides soluble... | 02/28/2012 |
| 8114839 | Protease resistant modified erythropoietin polypeptides Modified erythropoietin polypeptides that include the mutation R131Q, and uses thereof are provided. Also provided are pharmaceutical compositions, including compositions formulated for oral administration, that contain the modified erythropoietin polypeptides and u... | 02/14/2012 |
| 8101188 | Methods for the modulation of neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections Described is the modulation of the neovascularization and/or growth of collateral arteries and/or other arteries from preexisting arteriolar connections. Methods are provided for enhancing neovascularization and/or the growth of collateral arteries and/or other arte... | 01/24/2012 |
| 8084421 | Method of reducing blood glucose levels in type 2 diabetes patients by administering granulocyte-colony stimulating factor A method for treating adult onset neurodegenerative diseases and diabetes by administering an effective dose of Granulocyte-Colony Stimulating Factors. ... | 12/27/2011 |
| 8075902 | Diagnosis and treatment of cancer related to human dormancy New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation ... | 12/13/2011 |
| 8057802 | Treatment methods for fibrosis related disorders The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are p... | 11/15/2011 |
| 8052976 | Growth factor homolog ZVEGF3 Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residu... | 11/08/2011 |
| 8029799 | Use of thymosin alpha 1 for preparing a medicament for the treatment of stage IV malignant melanoma It is described the use of thymosin alpha in combination with dacarbazine and optionally with Interferon alpha, for preparing a medicament for the treatment of malignant melanoma on stage IV characterized by distant unresectable metastases. ... | 10/04/2011 |
| 8017129 | Use of thymosin alpha 1 for preparing a medicament for the treatment of stage IV malignant melanoma It is described the use of thymosin alpha in combination with dacarbazine and optionally with Interferon alpha, for preparing a medicament for the treatment of malignant melanoma on stage IV characterized by distant unresectable metastases. ... | 09/13/2011 |
| 7998929 | Solution preparations stabilized over long time A G-CSF solution formulation which is substantially free from proteins as a stabilizer but which contains at least one amino acid or a salt thereof as a stabilizer. ... | 08/16/2011 |
| 7994124 | Methods of use of G-CSF cysteine muteins The present invention relates to therapeutic methods for a protecting an animal from a disease or condition that can be treated by granulocyte colony-stimulating factor (G-CSF) wherein a composition comprising a cysteine variant of G-CSF is provided. Also disclosed ... | 08/09/2011 |
| 7976847 | Controlled release CGRP delivery composition for cardiovascular and renal indications The present invention provides methods of treating heart failure and improving renal function, and/or preventing the advancement of heart failure into advanced stages, and methods of counteracting ischemia due to a myocardial infarction by providing improved methods... | 07/12/2011 |
| 7973007 | Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammatio... | 07/05/2011 |
| 7956034 | FSH glycosylation variant D3N FSH mutant with increased glycosylation and longer half-life is described. The use of this FSH mutant for inducing folliculogenesis in human patients is also described. ... | 06/07/2011 |
| 7951381 | Method of stimulating epithelial cell proliferation by administration of gastrointestinal proliferative factor The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with th... | 05/31/2011 |
| 7951380 | Methods of stimulating bone growth using ZVEGF4 polypeptides Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residu... | 05/31/2011 |
| 7951382 | Methods for treatment of type 2 diabetes The present invention relates generally to the identification of biological markers associated with an increased risk of developing Diabetes, as well as methods of using such biological markers in diagnosis and prognosis of Diabetes. The biological markers of the in... | 05/31/2011 |
| 7947285 | Methods for preventing post endoscopic retrograde cholangiopancreatography pancreatitis The invention relates generally to methods for preventing post endoscopic retrograde cholangiopancreatography pancreatitis (ERCP). The method comprises administering a therapeutically effective amount of a pharmaceutical composition comprising secretin and a pharmac... | 05/24/2011 |
| 7943143 | Chloramphenicol acetyl transferase (CAT)-defective somatostatin fusion protein and uses thereof Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition, low cost adjuvants for enhanced immunogenic response are provided. Vac... | 05/17/2011 |
