Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 8282932 | Split-core-particles for the presentation of foreign molecules, especially for vaccine applications, and method for their production Disclosed are split-core carrier substance which, as separate polypeptide, have the core N domain and the core C domain of the core protein of a hepatitis B virus and at least one foreign molecule against which an immune response is to be induced. According to the i... | 10/09/2012 |
| 8067011 | Compositions and methods for treating B-cell malignancies The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells. ... | 11/29/2011 |
| 8017127 | Influenza immunogen and vaccine A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably e... | 09/13/2011 |
| 7964196 | Self-assembling nanoparticle drug delivery system A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, ... | 06/21/2011 |
| 7927601 | Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibitin... | 04/19/2011 |
| 7871625 | HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described. ... | 01/18/2011 |
| 7838002 | HCV core+1 protein, methods for diagnosis of HCV infections, prophylaxis, and for screening of anti-HCV agents The present invention relates to a novel form of core+1 protein of Hepatitis C virus (HCV), designated shorter form core+1 protein. The shorter form core+1 protein of Hepatitis C virus is the product of translation of a coding sequence consisting of all or part of a... | 11/23/2010 |
| 7811576 | Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations. ... | 10/12/2010 |
| 7785598 | Alternate reading frame hepatitis C virus peptides and uses thereof Novel hepatitis C virus (HCV) polypeptides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine compositions, in diagnosing HCV infection, and as therapeutic targets.... | 08/31/2010 |
| 7744898 | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV polymerase, and are particularly useful in treating or preventing HBV infection, inclu... | 06/29/2010 |
| 7713532 | HBV precore protein capable of forming particles There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Fu... | 05/11/2010 |
| 7658930 | Kit for detecting the antibody of HCV and its preparing method A kit and its preparing method concerning dual-antigen sandwich method are used for detecting the antibody against HCV, and its detecting mode is ‘carrier-first antigen-antibody against HCV to be detected-second antigen-marker-distinguishable signal’. The kit an... | 02/09/2010 |
| 7611713 | Inducing cellular immune responses to hepatitis B virus using peptide compositions This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in ... | 11/03/2009 |
| 7439347 | Hepatitis C virus non-structural NS3/4A fusion gene Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nuclei... | 10/21/2008 |
| 7413741 | HCV E1 comprising specific disulfide bridges The invention relates to recombinantly or synthetically produced HCV E1 envelope proteins or parts thereof comprising disulfides between specific cysteine residues. The invention further relates to viral-like particles and compositions comprising said HCV E1 envelop... | 08/19/2008 |
| 7405039 | Viral variants with altered susceptibility to nucleoside analogs and uses thereof The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibitin... | 07/29/2008 |
| 7402315 | Hepatitis-C virus type 4, 5 and 6 The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 ... | 07/22/2008 |
| 7393831 | Peptide compositions and their use against HCV The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following peptides: a peptide A having at least the amino acid sequence of SEQ ID N | 07/01/2008 |
| 7378234 | Method for isolating hepatitis C virus peptides Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule characterized by the following steps: —providing a pool of HCV-peptide, said... | 05/27/2008 |
| 7374766 | Compositions containing virus-like particles as immunopotentiators administered through the mucosa The present invention is related to the branch of medicine, particularly to the new formulations of vaccine antigens. The technical objective pursued with the present invention is, precisely, the development of formulations that are able to enhance the immune... | 05/20/2008 |
| 7368118 | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV envelope, and are particularly useful in treating or preventing HBV infection, includi... | 05/06/2008 |
| 7361352 | Influenza immunogen and vaccine A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably e... | 04/22/2008 |
| 7351413 | Stabilized HBc chimer particles as immunogens for chronic hepatitis A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protei... | 04/01/2008 |
| 7351570 | HDV nucleic acid molecules and applications thereof The invention concerns nucleic acid molecules derived from novel hepatitis D virus strains or isolates constituting genotypes different from known I, II and III genotypes, their fragments, corresponding proteins and their uses as diagnostic reagents. The invention a... | 04/01/2008 |
| 7348011 | Hepatitis C virus vaccine The present invention relates to isolation of a novel Hepatitis C virus, more particularly, the present invention relates to a viral class Hepatitis C, polypeptides, polynucleotide, vaccine and antibodies derived there from. ... | 03/25/2008 |
| 7341723 | Nucleic acid construct encoding a processing component derived from the N-terminal region of the hepatitis virus ORF2, and an antigenic polypeptide A method for enhancing an immune response to a nucleic acid vaccine comprising administering to an animal a nucleic acid construct encoding a fusion protein comprising a processing component and an antigenic polypeptide of interest wherein said processing component ... | 03/11/2008 |
| 7341726 | Modified HCV peptide immunogens Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, a... | 03/11/2008 |
| 7332595 | DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of pr... | 02/19/2008 |
| 7329408 | Eliciting HCV-specific antibodies Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E... | 02/12/2008 |
| 7323331 | Method for detecting or assaying HBV A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein o... | 01/29/2008 |
| 7320795 | Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations. ... | 01/22/2008 |
| 7319144 | Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope f... | 01/15/2008 |
| 7316905 | Method for measurement of hepatitis C virus A method for measurement of the hepatitis C virus (HCV) characterized by measuring HCV core antigen and HCV core antibody by their binding with probes in the presence of an anionic surfactant or a non-ionic surfactant, or both. ... | 01/08/2008 |
| 7314925 | Constructs and methods for expression of recombinant HCV envelope proteins The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian lysozyme signal peptide or a functional equivalent thereof joined to ... | 01/01/2008 |
| 7313357 | Method for typing and detecting HBV The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specific... | 12/25/2007 |
| 7307066 | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and pept... | 12/11/2007 |
| 7291723 | GB virus C and methods of treating viral infections The present application provides GB virus C sequences (GBV-C or hepatitis G virus) and methods of using the sequences. ... | 11/06/2007 |
| 7285539 | Activation of HCV-specific T cells The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides... | 10/23/2007 |
| 7279165 | Amyloid β1-6 antigen arrays The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composit... | 10/09/2007 |
| 7270820 | CD4+ T-lymphocyte-specific hepatitis C virus epitopes The invention relates to hepatitis C virus epitopes which are CD4+ T-lymphocyte specific, and to vaccines containing these epitopes. ... | 09/18/2007 |
