...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 8169610 | DNA sequencing system An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light sig... | 05/01/2012 |
| 8077314 | Measuring a characteristic of a multimode optical fiber To measure a characteristic of a multimode optical fiber, a light pulse source produces a light pulse for transmission into the multimode optical fiber. A spatial filter passes a portion of Brillouin backscattered light from the multimode optical fiber that is respo... | 12/13/2011 |
| 8018593 | Integrated nucleic acid analysis The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosu... | 09/13/2011 |
| 7978326 | DNA sequencing system An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light sig... | 07/12/2011 |
| 7929138 | Ambient-atmosphere glow discharge for determination of elemental concentration in solutions in a high-throughput or transient fashion An ambient atmosphere glow discharge spectrometer is disclosed having a capillary, two electrodes and a means for recording the atomic emissions. ... | 04/19/2011 |
| 7636159 | Time-delay integration in detection of labeled beads An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light sig... | 12/22/2009 |
| 7636160 | System for detecting markers An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light sig... | 12/22/2009 |
| 7545496 | Support with a surface structure for sensitive evanescent-field detection A support structure, such as an optical disc, is designed having surface structures formed on one or more surfaces of the support to enable formation of evanescent fields in a medium adjacent to the surface structures and allow for detection of optically-active subs... | 06/09/2009 |
| 7486396 | Electrophoretic system with multi-notch filter and laser excitation source Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecti... | 02/03/2009 |
| 7468793 | Time-delay integration in electrophoretic detection systems An apparatus for detecting analytes in a sample is provided. The apparatus includes: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with non-coherent radiation; a detector array disposed for ... | 12/23/2008 |
| 7428047 | Time-delay integration in a flow cytometry system An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least o... | 09/23/2008 |
| 7384781 | Sensors for biomolecular detection and cell classification A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample (5) comprising an ionic analyte and a detection reagent in a conductive fluid, wher... | 06/10/2008 |
| 7365847 | Method and apparatus for automated excision of samples from two-dimensional electrophoresis gels A system for automated excision of one or more samples from a sample media, including by using a device for electronically capturing one or more traits of samples in the media, using a microprocessor linked to the device to analyze the captured traits by comparison ... | 04/29/2008 |
| 7333213 | Confocal microscopy An improved confocal microscope system is provided which images sections of tissue utilizing heterodyne detection. The system has a synthesized light source for producing a single beam of light of multiple, different wavelengths using multiple laser sources. The bea... | 02/19/2008 |
| 7329333 | Uniform laser excitation and detection in capillary array electrophoresis system and method A capillary electrophoresis system comprises capillaries positioned in parallel to each other forming a plane. The capillaries are configured to allow samples to migrate. A light source is configured to illuminate the capillaries and the samples therein. This causes... | 02/12/2008 |
| 7323140 | Moving microdroplets in a microfluidic device The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms ... | 01/29/2008 |
| 7315357 | Imaging and analyzing parameters of small moving objects such as cells Light from an object such as a cell moving through an imaging system is collected and dispersed so that it is imaged onto a plurality of separate detectors. The light is spectrally dispersed by a plurality of spaced-apart dichroic reflectors, each detector receiving... | 01/01/2008 |
| 7312919 | Wide field of view and high speed scanning microscopy A wide field of view scanning microscope includes a light source, a light detector, optics, a scanning assembly, a translation system, and a data collection control and processing unit. The scanning assembly is constructed to provide from the light source a light be... | 12/25/2007 |
| 7298478 | Optical detector for a particle sorting system An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from ... | 11/20/2007 |
| 7295311 | Methods and apparatus for electrophoretic mobility determination using phase light scattering analysis An apparatus and method are disclosed for determining electrophoretic mobility using scattering light phase analysis comprising emitting a laser light along a path and transmitting a first portion of the laser light and reflecting a second portion of the laser light... | 11/13/2007 |
| 7288227 | Biochip reader with enhanced illumination and bioarray positioning apparatus A method of illumination and illumination apparatus are provided in a biochip reader. Illumination is provided by a non-collimated laser source or a light emitting diode (LED). The light is directed to opposing sides of a glass substrate by a pair of optical fiber b... | 10/30/2007 |
| 7286719 | Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging A multi-channel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a ... | 10/23/2007 |
| 7280207 | Time-delay integration in a flow cytometry system An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least o... | 10/09/2007 |
| 7270786 | Methods and systems for processing microfluidic samples of particle containing fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a microfabricated substrate having an enrichment channel to prepare an enriched cell sample from the cell-containing liquid. A flow through member is ... | 09/18/2007 |
| 7264971 | Read-head for optical diagnostic device A readhead for a photometric diagnostic instrument includes a housing adapted for incorporation within the photometric diagnostic instrument, and an elongated sample table operatively engaged with the housing. The sample table is configured to support elongated reag... | 09/04/2007 |
| 7265833 | Electrophoretic system with multi-notch filter and laser excitation source Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecti... | 09/04/2007 |
| 7262857 | Device for measuring immunochromatography test piece A measuring device 1 for immunochromatographic test strip 5a is configured to irradiate measurement light onto the immunochromatographic test strip 5a and to measure light from the immunochromatographic test strip 5a,... | 08/28/2007 |
| 7262847 | Optical assembly and method for detection of light transmission An optical assembly comprising a light source, at least one sample vessel and a detector. The detector comprises a plurality of detector locations and the vessel comprises a wall and core of relative shape and dimensions adapted to contain a sample for detection and... | 08/28/2007 |
| 7259849 | Optical system for micro analyzing system There is provided an optical system 8 for a micro analyzing system capable of precisely analyzing a sample. In the optical system 8, after light beams leaving the tip of an optical fiber 14 pass through a condensing part 13, a sample movi... | 08/21/2007 |
| 7259904 | Coarse spectrometer with a grating A quasi-monochromatic light beam carrier for a particular telecommunication channel is likely to experience drift because of age, temperature, or other factors, and may cause the centroid wavelength of the carrier to shift. Temperature adjustments by wavelength lock... | 08/21/2007 |
| 7250098 | Multi-capillary array electrophoresis device An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser ... | 07/31/2007 |
| 7250099 | Optical detection alignment coupling apparatus An apparatus for aligning a capillary column with one or more excitation fibers and with one or more optical lens elements for Capillary Electrophoresis. The apparatus includes two identical blocks having a plurality of grooves for positioning and aligning the capil... | 07/31/2007 |
| 7227122 | Image processing apparatus and method for processing images An image processing apparatus uses a camera to pick up images of an image pickup target illuminated by a transmission type illumination, via optical filters, and then allows a spectral characteristic estimating section and a pigment amount estimating section to calc... | 06/05/2007 |
| 7221457 | Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis A flow imaging system is used to implement surface plasmon resonance (SPR) detection to study bio-molecular interactions. The flow imaging system is used to capture SPR absorption spectra of large numbers of objects, where each object includes both a metal film capa... | 05/22/2007 |
| 7217562 | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluid... | 05/15/2007 |
| 7192557 | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicin... | 03/20/2007 |
| 7190832 | Computational methods for the segmentation of images of objects from background in a flow imaging instrument In automated computation-based interpretation of images, the accuracy and reliability of the detection and delineation of objects, known as “object segmentation,” is implemented so as to provide efficient performance. In a multi-step process, objects are first d... | 03/13/2007 |
| 7183103 | Instrument for monitoring polymerase chain reaction of DNA An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vial... | 02/27/2007 |
| 7179357 | Serial sample injection in capillary electrophoresis The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is performed by loading and running multiple sequential samples on each ... | 02/20/2007 |
| 7173704 | Measuring device for immunochromatography test piece and light source device A measuring device for immunochromatography test piece comprising an irradiation optical system for irradiating measurement light onto an immunochromatography test piece, and a detection optical system for detecting reflected light from the immunochromatography test... | 02/06/2007 |