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| Number | Title | Issue Date |
| 8174692 | High spatial resolution imaging of a structure of interest in a specimen In high spatial resolution imaging, a structure in a specimen is marked with a substance which, in a first electronic state, is excited by light of one wavelength to emit fluorescent light, which is also converted from its first into a second electronic state by tha... | 05/08/2012 |
| 8149399 | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains... | 04/03/2012 |
| 8139211 | Fluorescence polarization imaging device and method The present invention is directed to a novel multi-spectral exogenous fluorescence polarization imaging technique that enables rapid imaging of large tissue fields. The imaging device includes a tunable monochromatic light source and a CCD camera. Linear polarizers ... | 03/20/2012 |
| 8094302 | Spectrophotometer Disclosed herein is a spectrophotometer. The spectrophotometer includes a CPU having a signal prediction part and a comparison/calculation part. The signal prediction part predicts the strength of an output signal from a photodetection unit during the next period ba... | 01/10/2012 |
| 8045153 | Spectral image processing method, spectral image processing program, and spectral imaging system A spectral image processing system and method of performing robust unmixing on measurement noise. Based on an observed spectral image acquired from a specimen and emission spectral data of each of plural materials contained in the specimen, a contribution of each of... | 10/25/2011 |
| 8004674 | Data collection system and method for a flow cytometer A system for a flow cytometer that collects data for a sample prepared with a plurality of fluorochromes that includes a fixed gain detection system that collects data for a plurality of fluorescence channels, fluorochrome compensation factors for a plurality of flu... | 08/23/2011 |
| 8004673 | Photometric instrument A metallic structure is provided on a surface of a substrate. A component having a longer wavelength than excitation light is detected from luminescence from fixation positions of biomolecules and emitted from a material other than the biomolecules, and is used for ... | 08/23/2011 |
| 7995203 | Method for on-site drug detection in illicit drug samples The invention is intended for illicit drug detection, preferably to Cocaine detection in street samples containing in addition to Cocaine also adulterants and/or diluents (also denominated as cutting agents) used for increasing the quantity of the product and/or for... | 08/09/2011 |
| 7995202 | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains... | 08/09/2011 |
| 7965389 | Method for reconstructing the distribution of fluorophores in a non-homogeneous medium by optical tomography in continuous mode The method enables a non-homogeneous diffusing object to be examined by illuminating the object with a continuous light by means of a light source. It previously comprises reconstruction of the three-dimensional spatial mapping of an attenuation variable representat... | 06/21/2011 |
| 7961315 | Fluorescence detection enhancement using photonic crystal extraction Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent sc... | 06/14/2011 |
| 7961314 | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains... | 06/14/2011 |
| 7911607 | Light measuring device and scanning optical system A light measuring device is disclosed which can take in light from different portions of a plane light source efficiently to carry out measurement. The light measuring device for measuring light from a plane light source includes a spatial division device configured... | 03/22/2011 |
| 7907277 | Method and apparatus for downhole spectroscopy Apparatus and method for estimating a property of a downhole fluid including a carrier that is conveyed in a borehole, and a semiconductor electromagnetic energy source carried by the carrier, the semiconductor electromagnetic energy source having an active region t... | 03/15/2011 |
| 7869032 | Biosensors with porous dielectric surface for fluorescence enhancement and methods of manufacture Biosensors are disclosed which include a surface for binding to sample molecule to the biosensor in the form of a porous, thin film of dielectric material, e.g., TiO2. In one example the porous, thin film is in the form of a multitude of sub-micron sized ... | 01/11/2011 |
| 7864314 | Optical microscopy with phototransformable optical labels An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and ex... | 01/04/2011 |
| 7855785 | Fluorescence detection device This invention relates to a fluorescence detection device comprising a support means (101) for supporting a sample (111), a sample excitation means so that a fluorescence is emitted by the sample (111) and a detection means for detecting said fl... | 12/21/2010 |
| 7826052 | Correction method and measurement device for anti-stokes photoluminescence measurement A method to correct measurement error in a resonance energy-transfer assay, including exciting anti-Stokes photoluminescent donors with at least one wavelength of light which is greater than an emission wavelength of acceptor molecules; measuring emission at the acc... | 11/02/2010 |
| 7817268 | Alignment system for spectroscopic analysis The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscop... | 10/19/2010 |
| 7812945 | Fluorescence tomography using line-by-line forward model A fluorescence optical tomography system and method uses a photon migration model calculator for which absorption and reduced scattering coefficient values are determined for each source/detector pair. The coefficient values may be determined by measurement, in whic... | 10/12/2010 |
| 7812944 | Array for optical evaluation of an object array The invention relates to an array for optical evaluation of an object array, to which a microlens array (MLA), preferably an exchangeable and/or rotational microlens array, and a field lens with an illuminating device coupled by means of a beam splitter, preferably ... | 10/12/2010 |
| 7812946 | Deep-UV led and laser fluorescence apparatus for monitoring water quality A method for detecting trace levels of dissolved organic compounds and leached plastic compounds in drinking water includes the steps of employing deep ultraviolet light-emitting diode induced fluorescence at sensitivity levels of several parts per trillion in real ... | 10/12/2010 |
| 7800753 | Spectroscopic chemical analysis methods and apparatus Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and ... | 09/21/2010 |
| 7782457 | Optical microscopy with phototransformable optical labels First activation radiation is provided to a sample that includes phototransformable optical labels (“PTOLs”) to activate a first subset of the PTOLs in the sample. First excitation radiation is provided to the first subset of PTOLs in the sample to excite at lea... | 08/24/2010 |
| 7768640 | Fluorescence detection enhancement using photonic crystal extraction Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent sc... | 08/03/2010 |
| 7751041 | Fluorescence detection apparatus A fluorescent detection apparatus relates to an analysis technique for qualitatively detecting or quantifying biomolecules by producing an evanescent field on a surface of a substrate, exciting fluorescently labelled biomolecules on the substrate surface in the evan... | 07/06/2010 |
| 7724363 | Device for multifocal confocal microscopic determination of spatial distribution and for multifocal fluctuation analysis of fluorescent molecules and structures with flexible spectral detection Many points on a sample are tested simultaneously in parallel in an FCS method with multifocal illumination and/or detection. ... | 05/25/2010 |
| 7724364 | Small object identifying device and its identifying method A small object identifying device and its identifying method according to which a large number of small objects can be identified. In one embodiment, the device includes a dispersion region section which disperses a large quantity of several kinds of small objects w... | 05/25/2010 |
| 7710563 | Optical microscopy with phototransformable optical labels A method of imaging with an optical system characterized by a diffraction-limited resolution volume is disclosed. In a sample that includes a plurality of phototransformable optical labels (“PTOLs”) distributed in the sample with a density greater than an invers... | 05/04/2010 |
| 7705982 | Methods and apparatus for analyzing fluid properties of emulsions using fluorescence spectroscopy This relates to methods and apparatus for analyzing samples by fluorescence spectroscopy. In one embodiment, the methods and apparatus use a fluorescence detection unit (FDU) of a composition fluid analyzer (CFA™) module to detect variations in fluid properties (g... | 04/27/2010 |
| 7663748 | Autofocus mechanism for spectroscopic system An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. Th... | 02/16/2010 |
| 7652764 | Method for reconstructing a fluorescence-enhanced optic tomography image of an object with any outline The method enables a heterogeneous object containing fluorophores to be examined. A first face of the object is illuminated with an excitation light exciting the fluorophores. The light emitted by a second face of the object, opposite the first face, is detected by ... | 01/26/2010 |
| 7643142 | Apparatus for analyzing and sorting biological particles The invention provides an apparatus including (a) a frame having a boundary plane; (b) a flow chamber supported by the frame, the flow chamber placed a distance from the boundary plane; (c) a radiation source, the radiation source directed away from the flow chamber... | 01/05/2010 |
| 7630073 | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains... | 12/08/2009 |
| 7626694 | Optical microscopy with phototransformable optical labels First activation radiation is provided to a sample that includes fluorescent proteins (“FPs”) to activate a first subset of the FPs in the sample. First excitation radiation is provided to the first subset of FPs in the sample to excite at least some of the acti... | 12/01/2009 |
| 7626695 | Optical microscopy with phototransformable optical labels An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and ex... | 12/01/2009 |
| 7599059 | Monitoring molecular interactions using photon arrival-time interval distribution analysis A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more fluorophores and located in a confocal detection volume. The arrival time of e... | 10/06/2009 |
| 7599060 | Optical scanning configurations, systems, and methods involving at least one actuator for scanning a scan head An optical system includes a sample substrate having a surface, the surface defining a 2-dimensional sample plane. The system includes an excitation source configured to provide excitation light to the sample substrate. The system further includes an optical detecto... | 10/06/2009 |
| 7583380 | Spectroscopic analysis apparatus and method with excitation system and focus monitoring system The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analyzing an object, such as blood of a patient, and a corresponding analysis method. To aim the confocal detection volume inside a blood vessel orthogonal ... | 09/01/2009 |
| 7573571 | Airborne particulate discriminator A method and apparatus for rapid and accurate detection and discrimination of biological, radiological, and chemical particles in air. A suspect aerosol of the target particulates is treated with a taggant aerosol of ultrafine particulates. Coagulation of the taggan... | 08/11/2009 |
