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| Number | Title | Issue Date |
| 8184284 | Laser-processed substrate for molecular diagnostics Apparatus for use in performing a diagnostic assay of an analyte, the apparatus comprising a base that has been structured using laser processing so as to provide at least one patterned surface by melting and resolidification of the base, wherein the patterned surfa... | 05/22/2012 |
| 8184285 | Method and apparatus using volume holographic wavelength blockers The invention disclosed here teaches methods to fabricate and utilize a non-dispersive holographic wavelength blocker. The invention enables the observation of the Raman signal near the excitation wavelength (˜9 cm−1) with the compactness of standard t... | 05/22/2012 |
| 8179526 | Spectroscopic apparatus with dispersive device for collecting sample data in synchronism with relative movement of a focus In a Raman spectroscopy apparatus, exciting light is focussed on a sample (26) as a line focus 38. Spectra from points in the line focus are dispersed in rows 46 on a CCD detector 34, having a two-dimensional array of pixels. The line foc... | 05/15/2012 |
| 8179525 | Mirror mounted inside filter block of a fluorescence microscope to perform SERS and method thereof The present invention relates to spectroscopy, more particularly relates to a mirror made of glass plate and is coated with dielectric material, which is mounted inside filter block of fluorescence microscope to perform Surface Enhanced Raman Spectroscopy [SERS]. | 05/15/2012 |
| 8159663 | Laser microscope apparatus having a frequency dispersion adjuster To enable both observations of coherent anti-Stokes Raman scattering light and multiphoton fluorescence in a same apparatus so as to observe a specimen by various observation methods. There is provided a laser microscope apparatus comprising: two optical paths for g... | 04/17/2012 |
| 8159665 | Apparatus and methods for fluorescence subtraction in Raman spectroscopy An improved apparatus and method for fluorescence subtraction in Raman spectroscopy, where a narrow band light source and a broad band light source are utilized to stimulate Raman scattering and fluorescence emission from the same subject to produce two Raman/fluore... | 04/17/2012 |
| 8159662 | Systems and methods for remote unmanned raman spectroscopy A Raman spectroscopy sensor integrated with an unmanned ground vehicle (UGV) includes a UGV having a robot arm and a camera mounted on the robot arm. A laser and telescope associated with a Raman sensor are mounted on the robot arm in such a way as to point in subst... | 04/17/2012 |
| 8159664 | Apparatus for depth-selective Raman spectroscopy Apparatus and methods for detecting Raman spectral features non destructively from sub-surface regions of a diffusely scattering sample are disclosed. Incident radiation is supplied at one or more sample surface entry regions, and light is collected from one or more... | 04/17/2012 |
| 8154722 | Sensor element structure, sensor element array, and manufacturing method of sensor element array Even when only a few antigens exist in a specimen, a change in a dielectric constant and a change in an optical spectrum accompanied thereto in the periphery of a conductive member are made larger, so that sensing at high sensitivity can be performed. A structure in... | 04/10/2012 |
| 8149397 | Metallic nanostructures adapted for electromagnetic field enhancement The disclosure relates to metallic nanophotonic crescent structures, or “nanocrescent SERS probes,” that enhance detectable signals to facilitate molecular detections. More particularly, the nanocrescent SERS probes of the disclosure possess specialized geometri... | 04/03/2012 |
| 8134702 | Optical devices for surface enhanced Raman spectroscopy An optical device for surface enhanced Raman spectroscopy includes a substrate, and at least one antenna established thereon. The at least one antenna including at least two segments, where each segment is formed of a metal having a predetermined volume and a predet... | 03/13/2012 |
| 8130376 | Optical devices, spectroscopic systems and methods for detecting scattered light Certain examples described herein are directed to optical devices and systems that include first and second optical elements. In some examples, the first optical element may be configured to pass light received from an excitation source, and the second optical eleme... | 03/06/2012 |
| 8125635 | Compact, low cost raman monitor for single substances Apparatus for performing Raman analysis may include a laser source module, a beam delivery and signal collection module, a spectrum analysis module, and a digital signal processing module. The laser source module delivers a laser beam to the beam delivery and signal... | 02/28/2012 |
| 8125634 | Optical additive solc filter for deep ultraviolet applications An additive Šolc filter (ASF) includes i) a first polarizer for receiving an input light, such as from a monochromatic light source, and transmitting a first polarized output, ii) at least one birefringent plate positioned to receive the first polarizer output and ... | 02/28/2012 |
| 8120772 | Method for NRB-free nonlinear vibrational spectroscopy and miscroscopy Methods and systems are described for suppressing nonresonant background in broadband coherent anti-Stokes Raman scattering (CARS) microscopy and spectroscopy. The methods and systems improve sensitivity and signal to noise ratio in CARS. ... | 02/21/2012 |
| 8115920 | Method of making microarrays Provided is a method of making microarrays that includes providing a substrate with discrete first microfeatures that have a first profile, and depositing vapor-coated materials onto the first microfeatures to form second microfeatures having a second profile that i... | 02/14/2012 |
| 8115919 | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy Exemplary embodiments of methods, arrangements and systems for obtaining information about a sample can be provided. For example, in one exemplary embodiment, it is possible to receive a first electro-magnetic radiation from a sample which is based on a second elect... | 02/14/2012 |
| 8115921 | Probe for near-field light scattering and process for production thereof A probe for near-field light scattering, has, on the tip thereof, at least fine particles containing silver or silver oxide, a titanium oxide layer, and a silver layer at least in the named order from the surface thereof. A process for producing the probe for near-f... | 02/14/2012 |
| 8111393 | Structure for surface enhanced Raman spectroscopy A structure for surface enhanced Raman spectroscopy is disclosed herein. The structure is made up of a substrate, a self-assembled layer of first metal particles established on the substrate, and a self-assembled layer of second metal particles established such that... | 02/07/2012 |
| 8111394 | Raman spectrometer for monitoring traces of dissolved organic and inorganic substances A compact, ultra-sensitive, inexpensive NIR spontaneous Raman spectrometer is presented. High sensitivity is achieved by the use of a multi-pass cell configuration combined with the electromotive properties of silicon crystal surface. A thin layer of silicon oxide c... | 02/07/2012 |
| 8111392 | Raman spectrometer with display of laser power at the sample A Raman optical method and apparatus is utilized to automatically and accurately recognize laser power measurements made at a desired illumination sample plane. From such a configuration, the methods and systems disclosed herein, enable the support of multiple optic... | 02/07/2012 |
| 8107068 | Raman spectroscopy system and Raman spectroscopy detection method The present invention relates to a Raman spectroscopy system that includes a detection center. The detection center includes at least one light source for outputting exciting light which excites a detected object to generate Raman scattered light, and an analysis de... | 01/31/2012 |
| 8107069 | Method and apparatus for conducting Raman spectroscopy The apparatus disclosed herein features: (a) a handheld, portable spectrometer that includes a radiation source configured to direct incident radiation to a sample, a detector configured to receive signal radiation from the sample, and a housing enclosing the radiat... | 01/31/2012 |
| 8107070 | Methods of melamine detection and quantification Embodiments of the present disclosure relate to methods of melamine detection and quantification. In particular, embodiments of the present disclosure include the detection of very low concentrations of melamine using silver nanorod array substrates fabricated by ob... | 01/31/2012 |
| 8102524 | Degree-of-dispersion determination method for single-walled carbon nanotubes and degree-of-dispersion determination apparatus for single-walled carbon nanotubes Laser light having an energy of 1.9±0.1 eV is projected onto a carbon nanotube-containing substance so that a Raman spectrum is acquired. On the basis of the intensity of a peak at Raman shift 221±5 cm−1 caused by aggregates of single-walled carbon na... | 01/24/2012 |
| 8102525 | Systems and methods for detecting chemical and biological substances A method for detecting an ingredient in a food product or detecting a disease includes allowing a food sample solution obtained from a food product or a body fluid from an individual to come to contact with a nano-scale surface structure in a sensor, wherein the nan... | 01/24/2012 |
| 8085396 | Raman analysis Properties of turbid or scattering samples are determined using Raman spectroscopy with probe light delivered to and subsequently collected from the sample using a transmission geometry. The technique may be applied to pharmaceutical products such as tablets, diagno... | 12/27/2011 |
| 8077309 | Chemical analyzer for industrial process control An optical apparatus for measurement of industrial chemical processes. The analyzer uses Raman scattering and performs measurement of chemical concentrations in continuous or batch processes. The analyzer operates at a standoff distance from the analyte (or analytes... | 12/13/2011 |
| 8072595 | Time correlation system and method A time correlated single photon counting system having a programmable delay generator triggered by a laser fire event detector. The system may be used for chemical agent detection based on Rayleigh scattering using optical time domain reflectometry techniques. The s... | 12/06/2011 |
| 8068222 | Method and apparatus for microlens array/fiber optic imaging A novel approach for chemical imaging is disclosed. In one embodiment, the disclosure relates to a system for producing a spatially accurate wavelength-resolved image of a sample from photons scattered from the sample, comprising an optical lens; a first optical fib... | 11/29/2011 |
| 8064053 | 3-color multiplex CARS spectrometer The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband ... | 11/22/2011 |
| 8054461 | Systems for performing Raman spectroscopy Various embodiments of the present invention relate generally to systems for performing Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy comprises an analyte holder having a surface configured to retain an analyte and a light concent... | 11/08/2011 |
| 8054462 | Quantum efficiency enhancement device for array detectors Systems and methods for increasing the quantum efficiency of a photocathode used in an intensified an intensified array detector with a photocathode, such as a charge-coupled device (ICCD) are presented. A quantum efficiency enhancement device is disposed in front o... | 11/08/2011 |
| 8045152 | All optical nanoscale sensor A composition comprising a nanoparticle and at least one adsorbate associated with the nanoparticle, wherein the adsorbate displays at least one chemically responsive optical property. A method comprising associating an adsorbate with a nanoparticle, wherein the nan... | 10/25/2011 |
| 8031335 | Non-invasive disease diagnosis using light scattering probe A method for non-invasive detection of a disease, a status of illicit-drug use, or smoking status includes transferring a body fluid obtained from a patient to a sensor comprising a nano-scale surface structure to allow the body fluid to come in contact with the nan... | 10/04/2011 |
| 8027032 | Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency ω1, a second light source for providing a second train of pulses at a second center optical frequency ω2, a mo... | 09/27/2011 |
| 8027033 | Calibrated analyte concentration measurements in mixtures The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set... | 09/27/2011 |
| 8013992 | Methods of fabricating surface enhanced raman scattering substrates A method of fabricating a surface enhanced Raman scattering (SERS) substrate. In one embodiment, the method has the steps of simultaneously evaporating a metal at a first evaporation rate and a polymer at a second evaporation rate different from the first evaporatio... | 09/06/2011 |
| 8013991 | Raman difference spectra based disease classification A method to diagnosis a disease state of an unknown sample. A test Raman data set for an unknown sample is generated. A reference Raman database is provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman diffe... | 09/06/2011 |
| 8009289 | Spectroscopic analysis methods A spectroscopic analysis method in which spectral data of mixtures obtained from a plurality of points on a sample surface are resolved into component spectra and concentrations. A new alternating least squares multivariate curve resolution technique is presented wh... | 08/30/2011 |
