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| Number | Title | Issue Date |
| 8080788 | Linear ion trap as ion reactor In a linear ion trap ions of both positive and negative polarities are stored simultaneously for fragmentation reactions caused by electron transfer dissociation (ETD). The ion trap comprises a plurality of parallel pole rods or stacked rings and the ions are stored... | 12/20/2011 |
| 8044350 | Miniaturized ultrafine particle sizer and monitor An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical f... | 10/25/2011 |
| 7858934 | Quadrupole FAIMS apparatus A combined rf-only/FAIMS apparatus is disclosed for use in mass spectrometry and other applications. The disclosed apparatus includes a plurality of curved electrodes arranged around a central ion transmission channel. FAIMS functionality is removed electronically w... | 12/28/2010 |
| 7476854 | High speed, multiple mass spectrometry for ion sequencing A detector system for detecting trace molecules. The detector includes an ion trap that is coupled to an ionizer and a detector. The system also includes a controller that can generate voltage potentials within the ion trap. The controller can generate a voltage wav... | 01/13/2009 |
| 7449687 | Methods and compositions for combining ions and charged particles The invention provides an apparatus for combining ions and charged particles. In general, the apparatus contains: a) a multipole device having an ion exit end; b) a mass analyzer; and c) a source of charged particles. The apparatus is configured so that charged part... | 11/11/2008 |
| 7442921 | Protein profiles with atmospheric pressure ionization The invention relates to the acquisition of mass spectra of complex protein mixtures, often called protein profiles, for example to search for biomarkers which indicate stress situations, or to identify microbes. Up to now protein profiles have been acquired using i... | 10/28/2008 |
| 7420161 | Branched radio frequency multipole Systems and methods of the invention include a branched radio frequency multipole configured to act, for example, as an ion guide. The branched radio frequency multipole comprises multiple ion channels through which ions can be alternatively directed. The branched r... | 09/02/2008 |
| 7417225 | Apparatus and method for adjustment of ion separation resolution in FAIMS An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitt... | 08/26/2008 |
| 7405400 | Adjusting field conditions in linear ion processing apparatus for different modes of operation Methods for applying an RF field in a two-dimensional electrode structure include applying RF voltages to one or more main electrodes and compensation electrodes. The voltages on the one or more compensation electrodes may be adjusted to be proportional to the volta... | 07/29/2008 |
| 7405399 | Field conditions for ion excitation in linear ion processing apparatus Methods for applying an RF field in a two-dimensional electrode structure include applying RF voltages to main electrodes and to compensation electrodes. The voltages on the compensation electrodes may be proportional to the voltages on the main electrodes so as to ... | 07/29/2008 |
| 7399960 | Time of flight mass spectrometer A time of flight mass spectrometer according to the present invention includes: a) an ion source at which an ion starts flying; b) an energizer for giving a predetermined amount of energy to the ion to let the ion start flying from the ion source; c) an ion guide fo... | 07/15/2008 |
| 7399959 | Method and apparatus for enhanced ion based sample filtering and detection The invention provides, in various embodiments, systems and methods relating to enhancing the filtering and detection capability of ion mobility based systems by various techniques to counteract a charge buildup in the ion mobility based system. ... | 07/15/2008 |
| 7397029 | Method and apparatus for ion fragmentation in mass spectrometry An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, an... | 07/08/2008 |
| 7388196 | Hyperbolic horn helical mass spectrometer An improved rotating electric field ion mass spectrometer (REFIMS) provides for a smooth transition of the input ion beam from zero rotation to the desired level of field rotation. The REFIMS grid shape is changed from a fixed-diameter tunnel to that of a horn. The ... | 06/17/2008 |
| 7388195 | Apparatus and systems for processing samples for analysis via ion mobility spectrometry The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrom... | 06/17/2008 |
| 7388197 | Multiplex data acquisition modes for ion mobility-mass spectrometry A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. T... | 06/17/2008 |
| 7378651 | High field asymmetric waveform ion mobility spectrometer FAIMS Disclosed is an apparatus for separating ions including a plurality of first electrode portions, each first electrode portion of the plurality of first electrode portions having a first length and an outer surface that is at least partially curved in a direction tra... | 05/27/2008 |
| 7378648 | High-resolution ion isolation utilizing broadband waveform signals A desired ion is isolated in an ion trapping volume by applying an ion isolation signal to a plurality of ions in the ion trapping volume, including the desired ion to be retained in the ion trapping volume and an undesired ion to be ejected from the ion trapping vo... | 05/27/2008 |
| 7368709 | Low field mobility separation of ions using segmented cylindrical FAIMS A method of separating ions is disclosed. The method includes a step of providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region including at least one region of segmentation. The segmentation permits ion trapping, and a combination trapping ... | 05/06/2008 |
| 7368711 | Measuring cell for ion cyclotron resonance mass spectrometer The invention relates to a measuring cell for an ion cyclotron resonance mass spectrometer (FTMS). The invention provides a measuring cell which, on the one hand, consists of two ion-repelling RF grids at the front ends as trapping electrodes and thus produces a pur... | 05/06/2008 |
| 7355172 | Liquid cheromatography/mass spectrometry apparatus A liquid chromatography/mass spectrometry apparatus combines a chromatograph having a liquid delivery part for delivering mixed multiple solvents, and a mass spectrometer having an ionization part for spraying and ionizing. The apparatus has a storing part for stori... | 04/08/2008 |
| 7351955 | Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are c... | 04/01/2008 |
| 7342224 | Obtaining tandem mass spectrometry data for multiple parent ions in an ion population This invention relates to tandem mass spectrometry and, in particular, to tandem mass spectrometry using a linear ion trap and a time of flight detector to collect mass spectra to form a MS/MS experiment. The accepted standard is to store and mass analyze precursor ... | 03/11/2008 |
| 7339164 | Systems and methods for ion mobility control The invention provides, in various embodiments, systems and methods relating to controlling ion behavior in an ion-based analysis system. ... | 03/04/2008 |
| 7339165 | Dual outlet pyrolyzer for biological agent detection system A chemical biological detection system detects the presence of biological agents in the air. The system includes a pyrolyzer having an inlet through which air is drawn into the pyrolyzer and a pyrotube that collects a sample of particles extracted from the air. The ... | 03/04/2008 |
| 7326924 | Method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis using an ion trap mass analyser A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-... | 02/05/2008 |
| 7312444 | Atmosperic pressure quadrupole analyzer The present invention relates to an apparatus and method for focusing, separating, and detecting gas-phase ions using the principles of electrohydrodynamic quadrupole fields at high pressures, at or near atmospheric pressure. Ions are entrained in a concentric flow ... | 12/25/2007 |
| 7282708 | Method of selecting ions in an ion storage device The method of the present invention is to select ions having a predetermined mass to charge ratio by applying an ion selecting electric field in an ion storage space of an ion storage device. The method is characterized in that the ion selecting electric field is ge... | 10/16/2007 |
| 7276688 | Ion-optical phase volume compression The invention relates to a method for damping the kinetic energy of ions in ion cells filled with collision gas and with an exit aperture to drain the ions out of the cell. The invention uses a conditioning cell with an adjustable DC potential which decreases toward... | 10/02/2007 |
| 7274015 | Capacitive discharge plasma ion source In a system for chemical analysis, an RF-driven plasma ionization device including a pair of spaced-apart and plasma-isolated electrodes, the electrodes are connected to a power source wherein the electrodes act as plates of a capacitor of a resonant circuit, the ga... | 09/25/2007 |
| 7259379 | On-axis electron impact ion source An electron impact ion source includes an ionization chamber in which a first rf multipole field can be generated and an ion guide positioned downstream from the ionization chamber in which a second rf multipole field can be generated wherein electrons are injected ... | 08/21/2007 |
| 7247855 | Portable nuclear detector A portable nuclear material detector generally includes a scintillating fiber radiation sensor, a light detector, a conditioning circuit, a frequency shift keying (FSK) circuit, a fast Fourier transform (FFT) circuit, an electronic controller, an amplitude spectral ... | 07/24/2007 |
| 7247847 | Mass spectrometers and methods of ion separation and detection A mass spectrometer comprises an ion source which provides a beam of ions; a mass filter comprising a pair of electrodes and a drive circuit, the drive circuit operable to apply a time varying voltage to the electrodes having a profile that accelerates the ions to e... | 07/24/2007 |
| 7244931 | Ion mobility spectrometer with parallel running drift gas and ion carrier gas flows An ion mobility spectrometer is provided including at least one ionization chamber (1), which can be passed through by analyte-containing gas and at least one radiation source (2), from which ionizing radiation which is suitable for at least partially ... | 07/17/2007 |
| 7230238 | Method and apparatus for control of mobility-based ion species identification System for control of ion species behavior in a time-varying filter field of an ion mobility-based spectrometer to improve species identification, based on control of electrical and environmental aspects of sample analysis. ... | 06/12/2007 |
| 7227137 | Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on... | 06/05/2007 |
| 7227134 | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample The invention relates generally to ion mobility-based systems, methods and devices for analyzing samples. ... | 06/05/2007 |
| 7227133 | Methods and apparatus for electron or positron capture dissociation The present invention relates to mass spectrometers capable of performing electron (or positron) capture dissociation, methods of performing tandem mass spectrometry, methods of performing electron capture dissociation, and methods of performing positron capture dis... | 06/05/2007 |
| 7223965 | Method, system, and device for optimizing an FTMS variable Certain exemplary embodiments provide a method for automatically optimizing an FTMS. The method can comprise a plurality of potential activities, some of which can be automatically, repeatedly, and/or nestedly performed, and some of which follow. A composite amplitu... | 05/29/2007 |
| 7223967 | Side-to-side FAIMS apparatus having an analyzer region with non-uniform spacing and method therefore Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) having a side-to-side electrode geometry. The FAIMS includes an inner electrode (102) having a length and an outer surface that is curved in a direction transverse to the length. ... | 05/29/2007 |
