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| Number | Title | Issue Date |
| 8183525 | Method and system for analysing a dose formulation of a metered dose device One aspect of the invention features a method of analyzing dose metered devices by: spraying an aerosol from a metered dose device directly into a spray chamber of a mass spectrometer detector by firing a dose from a metered dose device, for example a pMDI, by depre... | 05/22/2012 |
| 8173960 | Low pressure electrospray ionization system and process for effective transmission of ions Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An “interfaceless” electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standa... | 05/08/2012 |
| 8173959 | Real-time trace detection by high field and low field ion mobility and mass spectrometry A trace detection system includes at least two stages coupled to operate in series. An ion mobility spectrometer (IMS) stage has a sampling inlet to receive a sample to be analyzed. An ion source ionizes the sample. The IMS applies an electrical field to the ionized... | 05/08/2012 |
| 8164055 | Sample plate designs for MALDI and DESI for molecular imaging of coated medical devices on the applied biosystems Qstar/Voyager MALDI mass spectrometer Holding devices for securely holding medical devices, such as stents, are utilized in performing molecular imaging of the medical devices. ... | 04/24/2012 |
| 8158934 | Electron capture dissociation apparatus and related methods An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along ... | 04/17/2012 |
| 8158933 | Detector apparatus and pre-concentrator An IMS detector has a pin-hole or capillary inlet having a coating of an adsorbent material, such as polydimethylsiloxane, which is adsorbent to an analyte substance of interest. The analyte is adsorbed into the material until a heater is energized to heat the adsor... | 04/17/2012 |
| 8158936 | Ionization probe assemblies The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose. ... | 04/17/2012 |
| 8153964 | Ultrasound ionization mass spectrometer Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, incl... | 04/10/2012 |
| 8148681 | Microengineered vacuum interface for an ionization system A planar component for interfacing an atmospheric pressure ionizer to a vacuum system is described. The component combines electrostatic optics and skimmers with an internal chamber that can be filled with a gas at a prescribed pressure and is fabricated by lithogra... | 04/03/2012 |
| 8138473 | Mass spectrometry unit A mass spectrometry unit of the present invention includes a mass spectrometry portion that detects ion current values of a gas to be measured according to mass-to-charge ratio, to thereby measure partial pressures of the gas to be measured. The mass spectrometry un... | 03/20/2012 |
| 8129676 | Surface enhanced Raman spectroscopy detection with ion separation pre-filter Detecting and identifying ions using surface enhanced Raman spectroscopy (SERS) and an ion separation pre-filter, such as an ion spectrometer, are provided. The combination of an ion separator as a pre-filter for SERS provides a highly sensitive detector with very l... | 03/06/2012 |
| 8129677 | Method and apparatus for surface desorption ionization by charged particles An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that ch... | 03/06/2012 |
| 8119983 | GC-MS analyzer switchable between one-dimensional and two-dimensional modes One-dimensional GC-MS/olfactory analysis and two-dimensional GC-MS/olfactory analysis can be freely performed in one analyzer by a simple switching operation, without changing the device configuration. An odor component analyzer is used which includes a sample injec... | 02/21/2012 |
| 8119984 | Method and apparatus for generation of reagent ions in a mass spectrometer A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the rea... | 02/21/2012 |
| 8110797 | Electrospray ionization mass spectrometry methodology A method of enhanced speciation of both positive and negatives species in an analyte is disclosed. The method can include producing a first analyte solution comprising an analyte composition and an effective amount of silver triflate, and analyzing the first analyte... | 02/07/2012 |
| 8110796 | Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the pla... | 02/07/2012 |
| 8106352 | Multi-dimensional ion mobility spectrometry methods and apparatus Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independ... | 01/31/2012 |
| 8106353 | Apparatus and method of photo fragmentation A method of photo-fragmentation is provided generating a beam of ions from a sample with an ion source, filtering the beam of ions in a filtering region to select desired ions, and photo-fragmenting the desired ions in a photo-fragmentation region having a higher pr... | 01/31/2012 |
| 8097845 | Focused analyte spray emission apparatus and process for mass spectrometric analysis An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between t... | 01/17/2012 |
| RE43078 | Atmospheric pressure ion source A non-radioactive atmospheric pressure device for ionization of analytes comprises an atmospheric pressure chamber having an inlet for carrier gas, a first electrode at one end, and a counter-electrode at the other end of the chamber for creating an electrical disch... | 01/10/2012 |
| 8084735 | Pulsed voltage electrospray ion source and method for preventing analyte electrolysis An electrospray ion source and method of operation includes the application of pulsed voltage to prevent electrolysis of analytes with a low electrochemical potential. The electrospray ion source can include an emitter, a counter electrode, and a power supply. The e... | 12/27/2011 |
| 8084734 | Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays The present invention provides a method of producing a laser-patterned silicon surface, especially silicon wafers for use in laser desorption ionization (LDI-MS) (including MALDI-MS and SELDI-MS), devices containing the same, and methods of testing samples employing... | 12/27/2011 |
| 8080784 | Ionization device A plate for matrix-assisted laser desorption ionization (MALDI) mass spectrometry comprising an electrically conductive substrate (1) covered with a light sensitive matrix (2), the matrix (2) comprising a light absorber, a charge carrier, a prob... | 12/20/2011 |
| 8080783 | Atmospheric pressure ion source for mass spectrometry A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in t... | 12/20/2011 |
| 8076638 | Drift tube structure for ion mobility spectrometer A drift tube structure for ion mobility spectrometer is disclosed comprising electrode sheets and insulation parts arranged in alternation, with each electrode sheet being a mesh metal sheet having a radian or taper portion which is convexly curved toward an ion inp... | 12/13/2011 |
| 8076639 | Method and system for desorption atmospheric pressure chemical ionization A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. ... | 12/13/2011 |
| 8071941 | Mass spectrometer A cathode configuration for emission of electrons has a reaction zone connected to an entrance opening for the supply of neutral particles. The opening communicates with the cathode configuration for the ionization of the neutral particles and an ion extraction syst... | 12/06/2011 |
| 8067730 | Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI). ... | 11/29/2011 |
| 8063361 | Ion mobility based separation methods and apparatus The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhan... | 11/22/2011 |
| 8058611 | System for preventing backflow in an ion source A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion ... | 11/15/2011 |
| 8058610 | Mass spectrometer A sample plate 3 with a sample 4 placed thereon is initially set on a stage 2, and a visual image of the sample is taken with a CCD camera 14. This image is stored in an image data memory 23. Then, an operator removes the sample pl... | 11/15/2011 |
| 8044348 | Ion source vessel and methods An ion source and method for providing ionized particles to a molecular/atomic analyser, such as a mass spectrometer, are disclosed. The ion source includes a vessel defining a channel; a gas inlet extending from the gas source into the channel, for introducing a ga... | 10/25/2011 |
| 8044346 | Method and system for desorbing and ionizing chemical compounds from surfaces The invention relates to a method and system for ionizing analyte-containing sample lying on a surface of a substrate. The method comprises directing to the sample a heated flow of desorption gas in order to desorb analyte from the surface, and simultaneously direct... | 10/25/2011 |
| 8044347 | Method for processing mass analysis data and mass spectrometer Intensity data of the signals produced by an ion detector are sequentially stored in a data processor, with each piece of intensity data being associated with time t required for each of the various ions ejected from an ion trap to fly through a time-of-flight space... | 10/25/2011 |
| 8039795 | Ion sources for improved ionization Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry. ... | 10/18/2011 |
| 8026479 | Systems and methods for analyzing substances using a mass spectrometer Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigg... | 09/27/2011 |
| 8026477 | Sampling system for use with surface ionization spectroscopy In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the... | 09/27/2011 |
| 8026478 | Mass spectrometer An Electrospray ionization ion source is disclosed comprising a capillary tube surrounded by a gas nebulizer tube. One or more wires are provided within the capillary tube. An analyte solution is supplied to the capillary tube and a nebulizing gas is supplied to the... | 09/27/2011 |
| 8022361 | Monolithic multinozzle emitters for nanoelectrospray mass spectrometry Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM2 emitters), a bottom up approach using silicon nanowires on a silicon s... | 09/20/2011 |
| 8022362 | Ionization device An ionization device includes an ionization chamber (1) and a charging chamber (20) separately prepared therefrom. The ionization chamber (1) has a discharge electrode (6) and an opposing electrode (10) in an interior (4) of... | 09/20/2011 |
