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Class 210/198.2 - Chromatography


Subclass of Class 210 - Liquid purification or separation
Definition: Apparatus for carrying out the process of chromatography.
No. of patents: 2319
Last issue date: 05/22/2012


1                      
NumberTitleIssue Date
8182679Organosilanes and substrate bonded with same
The present invention, provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for u...
05/22/2012
8182680Primary piston correction during transfer
A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The ...
05/22/2012
8163177Delivery and assessment system for the automated manufacturing of high performance nanofluidic separation devices
A multi-column packing system and packed bed assessment system for producing small bore LC columns of superior quality, improved column-to-column reproducibility, and lower cost than current commercially available columns. The process utilizes an automated multi-col...
04/24/2012
8147690Chromatography column
A chromatography column includes a tube, a fit assembly, a first end fitting and a second end fitting. An annular protrusion extends from an end face of the tube to a protrusion height and circumscribes a chamber in fluid communication with the axial bore. Both the ...
04/03/2012
8137548Chelator-modified inorganic oxide particles
The present invention is directed to inorganic oxide particles that have been modified with a chelator group. In an embodiment, the chelator group is covalently bonded to a polymer. In an embodiment, the chelator group is covalently bonded to a chiral selector ligan...
03/20/2012
8137549Automated packing system and method for chromatography columns
A column packing system comprises a control unit provided with software for calculating the breakpoint where a movable adapter comes into contact with a settled bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the...
03/20/2012
8133390Reversed endcapping and bonding of chromatographic stationary phases using hydrosilanes
A process for producing a chromatographic stationary phase for use in reversed-phase chromatography. Chromatographic stationary phases prepared according to the methods of the current invention and liquid chromatography columns, which include the stationary phases, ...
03/13/2012
8128816Piston movement control for preparative chromatography column
In an axial-flow preparative chromatography column that contains a piston, commonly termed an adaptor, that is lowered over the top of the resin, the ability to lower the piston in a controlled manner to minimize the chances of damage to the resin is achieved by use...
03/06/2012
8114281Fraction collector with adjustable tray
A fraction collector comprising a movable tray is provided. The movable tray may be attached to the fraction collector support system in a variety of ways and adjusted without adjusting the parts of the fraction collector support system. The moveable tray may be sta...
02/14/2012
8114280Separation matrix and method of purification
The present invention relates to a separation matrix comprised of a porous support to which ligands have been immobilized, wherein said ligands comprise at least one sulphonamide and the R group of the sulphonyl comprises an aromatic group. The nitrogen of the sulph...
02/14/2012
8114282Method and installation for regulating the modifier level in chromatography or supercritical extraction with recycling
A chromatography or supercritical extraction method is disclosed, in which the eluent comprises a mixture of a fluid and a modifier and in which the fluid is recycled. One exemplary method comprises an operation consisting in determining at least one quantity linked...
02/14/2012
8101073Separating agent for solid-phase extraction
The present invention relates to a separating agent for solid-phase extraction which comprises core particles of a base material; a hydrophilic polymer layer formed on the surface of the particles; and a hydrophobic polymer layer formed on the surface of the hydroph...
01/24/2012
8092677Separating agent for an enantiomeric isomer
The present invention is to provide a method of producing a separating agent for an enantiomeric isomer having a high optical resolution power together with sufficient solvent resistance. That is, a method of producing a separating agent for an enantiomeric isomer c...
01/10/2012
8075767Integrated high throughput system for the analysis of biomolecules
Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activat...
12/13/2011
8075768Liquid chromatograph device
A liquid chromatograph device was provided wherein operations inside a thermostatic chamber can be safely performed even while a heat block is being heated. The liquid chromatograph device comprises: a thermostatic chamber; outer doors and that are disposed at the f...
12/13/2011
8066876Apparatus and methods for packing chromatography columns
A chromatographic apparatus may include a hydraulic lifting mechanism axially movable from a lowered position to a raised position such that a column and flange of the apparatus are axially movable with the hydraulic lifting mechanism. In a packing system, a mobile ...
11/29/2011
8066875Flash chromatography cartridge
A low pressure liquid chromatographic cartridge is provided having a tubular polymer container adapted to receive a chromatographic packing material. The container has an outlet port located at a downstream end of the container and container threads formed on an ups...
11/29/2011
8062516Low thermal mass, adjustable locking GC nut
A connector for fastening a gas chromatography capillary column to chromatography equipment includes a securing nut and ferrule on a first portion of the connector for releasably holding the capillary column in a position relative to a second portion of the connecto...
11/22/2011
8062515Parking a sample stream and suppressing the sample
Pretreatment method and apparatus to remove matrix ions from a liquid sample, prior to separation of the sample analytes (e.g. by chromatography), by flowing the liquid sample into a sample compartment and stopping the flow. The sample compartment has a wall compris...
11/22/2011
8057668Method and device for extracting an analyte
The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a ...
11/15/2011
8034239Device for sample preparation
This invention relates to a pipette tip or tube designed to perform biological or chemical sample preparation, purification or separation. The narrow end of the pipette tip is twisted in such a way that it forms a narrow spiral passage, which allows the retention of...
10/11/2011
7981284Suppressor utilizing micro ion exchange tube and ion chromatograph utilizing the same
Disclosed herein is a suppressor using one ion-exchange tube which has an inner diameter close to that of a tube connected to a separation column and which is constituted by an ion-exchange membrane. The ion-exchange tube is folded or wound more than once in a plane...
07/19/2011
7972506Chromatography columns and their operation
A chromatography column (100) is disclosed comprising a housing (10) comprising a tubular side wall (1); opposed, axially spaced end units (2,3) which together with the side wall define an enclosed bed space to contain a bed of particulat...
07/05/2011
7964097Multicapillary column for chromatography and sample preparation
A multicapillary column especially useful for liquid chromatography and sample preparation comprising a plurality of uniform capillaries coated with an insoluble stationary phase, wherein the thickness of the stationary phase is correlated with the radius of the ind...
06/21/2011
7959801Device for generating micro- and nanoflow mobile phase gradients for high-performance liquid chromatography
A device for generating micro- and nanoflow mobile phase gradients for high performance liquid chromatography includes a generator of micro- and nanoflows of at least two mobile phases in different percentage compositions; an n-position gradient distributor having i...
06/14/2011
7947174Sol-gel monolithic column with optical window and method of making
A method of preparing a sol-gel monolithic column includes the step of forming a separation bed (14) from a sol-gel solution in a single process step. This column has improved characteristics for CEC based on its incorporated surface charge and ease of operat...
05/24/2011
7947175Continuous countercurrent tangential chromatography (CCTC)
The present invention is a system for continuous, single-pass countercurrent tangential chromatography having multiple single-pass modules. A single-pass binding step module is used for binding product from an unpurified product solution with a resin slurry. A singl...
05/24/2011
7938961Capillary loop with a built-in retaining frit
Disclosed herein are an apparatus and method for effectuating increased chromatographic efficiency in a capillary column by employing a retaining frit disposed within an analytical capillary. By disposing the retaining frit within the analytic capillary, the void vo...
05/10/2011
7938962Separating agent for enantiomeric isomers and method of producing the same
A separating agent which combines a high optical resolving power inherent in polysaccharide derivatives with sufficient solvent resistance and a method with which the separating agent can be produced efficiently in short steps. The separating agent for enantiomeric ...
05/10/2011
7927486Polymer modified porous substrate for solid phase extraction
A polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polymeric monolith formed thereon, wherein the polymeric monolith comprises C5-10 monocyclic or bicyclic aryl or heteroaryl, optionally s...
04/19/2011
7927487Chromatographic column system
Chromatographic column system, in particular a chromatographic column system of the expanded bed adsorption column type comprises a column connected to a fluid inlet and a fluid outlet and dimensioned to comprise an expandable filter bed between said fluid inlet and...
04/19/2011
7914673Fluid distribution apparatus
Disclosed is a mixer-distributor-collector apparatus for use between beds of solid particles in a fluid-solid contacting vessel. The apparatus includes a solids retaining screen, fluid deflector, passageway, fluid distributor, and flow manipulator. The flow manipula...
03/29/2011
7909993Centrifugal fraction collection system and method
A centrifugal fraction collection system including a rotating carrier for holding at least one sample collection container and inducing a centrifugal force, a guide disposed on the rotating carrier, and a flexible eluant tube disposed over the rotating carrier and t...
03/22/2011
7909994Mobile phase dilution scheme for enhanced chromatography
A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a sample. A sample is injected into the strong mobile phase, and subsequ...
03/22/2011
7901573Separation column and liquid chromatography apparatus using the same
Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block. A monolith rod 1
03/08/2011
7901574Quick disconnect liquid chromatograph columns
A chromatography column comprising a chromatography tube, a piston tube with a porous obstruction that inhibits the movement of particle solids therethrough, and a quick connect/disconnect clamp for use in coupling the chromatography tube to the piston tube. This co...
03/08/2011
7897044Fluid separation device
The present invention relates to a fluidic separation device comprising: at least one microchannel (2; 66) extending along a longitudinal axis (X), the microchannel having a cross-section that presents a width measured along...
03/01/2011
7875175Mobile phase dilution scheme for enhanced chromatography
A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a sample. A sample is injected into the strong mobile phase, and subsequ...
01/25/2011
7867391Cucurbituril derivative-bonded solid substrate and biochip using the same
The present disclosure provides a cucurbituril derivative-bonded solid substrate in which cucurbituril derivatives of Formula 1 are covalently bonded to a modified solid substrate of Formula 2. The cucurbituril derivative provides functional groups which can be used...
01/11/2011
7862716HPLC schematic with integrated sample cleaning system
The disclosed HPLC flow schematic back-flushes the guard column with mobile phase once every operating cycle, the regular cleaning maintaining its effectiveness and useful life. This mobile phase flow reversal is accomplished by imposing a two position multiple port...
01/04/2011
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