Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 7854827 | Comparative multidimensional gel electrophoresis A device providing an arrangement for the separation of a sample mixture for analytical reasons based on multidimensional gel electrophoresis and method thereof are disclosed. The separation involves a first separation in a first dimension of the device on the basis... | 12/21/2010 |
| 7435322 | Device and method for automatically analysing the constituents of an analyte The invention relates to a device and a method for automatically analysing the constituents of at least one analyte, especially by means of gel electrophoresis and/or isoelectric focussing, comprising at least one separating matrix, especially a gel. Each separating... | 10/14/2008 |
| 7316771 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 01/08/2008 |
| 7282128 | Buffers for electrophoresis and use thereof Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS a... | 10/16/2007 |
| 7250100 | Two dimensional electrophoresis cassette A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away from the fir... | 07/31/2007 |
| 7247224 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 07/24/2007 |
| 7238269 | Sample processing device with unvented channel A device includes a substrate having first and second major surfaces and a hub that defines an axis of rotation for the substrate, and an unvented channel having a plurality of connected compartments. Methods for using devices of the invention are also disclosed. | 07/03/2007 |
| 7198703 | Chamber-forming electrophoresis cassette cover A multielevational cover for assembling a fluid retaining chamber on a face of an electrophoresis cassette is presented. The cover comprises a cassette-containing member, at least one chamber-defining member, and sealing means, typically sealing means that are capab... | 04/03/2007 |
| 7166202 | Matrixes, arrays, systems and methods The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for c... | 01/23/2007 |
| 7153405 | Cassette, system, and 2-D gel electrophoresis method for separating molecules A gel electrophoresis cassette (33) is disclosed which includes two plates (34, 35) and at least one seal (36) which separates these plates. The seal (36) is annular; it may be positioned essentially in the region of the outer edge of the... | 12/26/2006 |
| 7077940 | Strip holder, chamber, cassette, and 2-D gel electrophoresis method and system for performing this method for separating molecules A strip holder (1) is disclosed for accommodating a gel strip (3) for separating molecules using gel electrophoresis. The strip holder (1) disclosed is distinguished by including a baseplate (4), at least one stop (5), which is off... | 07/18/2006 |
| 7022214 | Carrier ampholytes of high pH range Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric ... | 04/04/2006 |
| 6979390 | Method and apparatus for separating biological molecules A system for separating biological molecules includes a chip (10) on which there is an electrophoresis separation microchannel (16). At the start of the channel there is an isoelectric focusing section (14) containing a gel having a pH gradient.... | 12/27/2005 |
| 6942774 | Electrophoresis apparatus and a method of using the same An apparatus for rehydrating and for performing electrophoresis on a gel strip includes a tray defining a plurality of parallel troughs configured to receive gel strips. Each trough defines a centrally located rehydration area and an electrode area disposed either s... | 09/13/2005 |
| 6936150 | Methods and apparatus for electrophoresis of prior-cast, hydratable separation media Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips. The method exploits the swelling of prior-cast, hydratable separation media upon rehydration to help lodge ... | 08/30/2005 |
| 6923896 | Electrophoresis apparatus and method An electrophoretic apparatus comprising: a first electrolyte chamber containing a first electrode; a second electrolyte chamber containing a second electrode; a first sample chamber disposed between the first and second electrolyte chambers and proximate to the firs... | 08/02/2005 |
| 6852206 | Measurement of fluorescence using capillary isoelectric focusing Improved apparatus is disclosed for carrying out axially illuminated laser induced fluorescence whole-column imaging detection in the capillary isoelectric focusing of proteins. The separation capillary was made of low refractive index Teflon conditioned with methyl... | 02/08/2005 |
| 6837977 | Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug of a mixture of the target and a complex material sample, and a separ... | 01/04/2005 |
| 6833061 | Methods for isoelectric particle separation In order to isoelectrically separate particles with a pH-dependent net charge, the particles are exposed in a guiding liquid to electric field forces. The pH value of the guiding liquid is set in such a way that at least one predetermined type of particle is separat... | 12/21/2004 |
| 6793791 | Variable-volume disposable isoelectric focusing cell and method of isoelectric focusing An elastomeric cell is used as the disposable part of an apparatus for isoelectric focusing in free solution (without gels) in the 0.5 to 5 ml volume range. An inlet port is used for priming the cell and end-connectors for coupling with electrodes. A grid of paralle... | 09/21/2004 |
| 6783648 | Method and apparatus for unloading gels from isoelectric gel tubes An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for supporting the plunger rod. The first support is mounted on a movable ... | 08/31/2004 |
| 6761810 | Automated apparatus including a robotic arm for loading samples into wells for first dimension electrophoresis separation An automated assembly for performing first dimension electrophoresis is described herein that includes a supply magazine, an electrophoresis tank and an automated transferring device that robotically transfers biological samples from sample vials retained in the sup... | 07/13/2004 |
| 6685811 | Method for separation of macromolecules The invention relates to a method and a system, suitable for automation, for the, preferably preparative, separation of amphoteric macromolecules, e.g. proteins or peptides, wherein said method comprises the steps of: (a) subjecting said mixture of macrom... | 02/03/2004 |
| 6638408 | Method and device for separation of charged molecules by solution isoelectric focusing The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples ... | 10/28/2003 |
| 6537434 | First dimension electrophoresis separation method and apparatus An automated apparatus for carrying out a first dimension electrophoresis separation of proteins and other macromolecules includes a supply magazine, an automated transferring device and an electrophoresis tank. The supply magazine includes a carousel for... | 03/25/2003 |
| 6524866 | Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one to rank various ligands based on their relative affinity, i... | 02/25/2003 |
| 6379970 | Analysis of differential protein expression A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that are differentially present in the samples.... | 04/30/2002 |
| 6277259 | High performance multidimensional proteome analyzer A proteome analyzer includes a separation cassette having a first dimension separation compartment for separation of protein samples by isoelectric focusing and a second dimension separation compartment for separation of protein samples by SDS-polymer net... | 08/21/2001 |
| 6156182 | Encapsulated IPG Strips Immobilized pH gradient (IPG) strips are encapsulated in an enclosure that seals the strip from atmospheric exposure and yet contains sufficient volumetric capacity to accommodate the strip in rehydrated form. The enclosure contains a pair of electrode ac... | 12/05/2000 |
| 6013165 | Electrophoresis apparatus and method Disclosed are an apparatus, system, and method for two dimensional electrophoresis of analytes of interest, particularly polypeptides. The apparatus includes a sample separation cavity comprising (1) an electrophoresis region located along an upper portio... | 01/11/2000 |
| 5993627 | Automated system for two-dimensional electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 11/30/1999 |
| 5759370 | Method and device for isoelectric focusing without carrier ampholytes A device and method for isoelectric focusing of ampholytes in a buffer uses a cone-shaped capillary with a positive electrode connected at a narrow end and a negative electrode connected at the wide end of the capillary. The electrical potential across th... | 06/02/1998 |
| 5609743 | Electrophoresis fractionator An electrophoresis fractionator comprises a multiplicity of separate cells (10, 11) provided on respective contact surfaces of two members (1, 2) which are in contact with each other movably relative to each other and move relative to each other to enable... | 03/11/1997 |
| 5540826 | Multi-channel separation device A multi-channel separation device is provided for use in separation technology, particularly in electrophoresis and in isoelectric focusing. The device includes two mating plates, at least one of which contains an array of at least three cavities arranged... | 07/30/1996 |
| 5534121 | Preparative two dimensional gel electrophoresis system A preparative two dimensional gel electrophoresis system which serves as a single procedure for separation and isolation of preparative amounts of proteins from complex biological preparations. The system includes sized-up isoelectric focusing tube gels a... | 07/09/1996 |
| 5512158 | Capillary electrophoresis method and apparatus for electric field uniformity and minimal dispersion of sample fractions A capillary electrophoresis method and apparatus for reducing dispersion of sample fractions are disclosed. The capillary tube in which the electrophoresis is performed has been flared, at least at its sample entrance end, to remove sharp corners which co... | 04/30/1996 |
| 5500188 | Device for photoresponsive detection and discrimination Photoresponsive devices including a photoresponsive electrode are provided, and methods for their use to measure changes in environment at a site at or about the surface of the photoresponsive device. By employing a source of light for irradiating a site ... | 03/19/1996 |
| 5466348 | Methods and devices for enhanced biochemical sensing A method and application for detecting and measuring the presence of a binding target material employs a semiconductor device having a receptor-covered surface topgate, separated by a dielectric layer from a substrate. Receptors attached to this surface e... | 11/14/1995 |
| 5407546 | Method for high-resolution two-dimensional electrophoresis and device for carrying out the same For high-resolution two-dimensional electrophoresis comprising the steps of carrying out, on a gel base, at first a first separation process in a first direction and then a second separation process in a direction vertical to the first direction by a tech... | 04/18/1995 |
| 5234586 | On-line product identification in a chromatography effluent by subtraction Disclosed is a method and apparatus for the rapid identification of a solute of interest in an effluent stream. The method involves separation of the solutes in the effluent and identification of a particular solute of interest by its selective subtractio... | 08/10/1993 |
