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Class 204/451 - Capillary electrophoresis


Subclass of Class 204 - Chemistry: electrical and wave energy
Definition: Process involving electromigration of particles or components
No. of patents: 607
Last issue date: 05/08/2012


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NumberTitleIssue Date
8173001Method and apparatus for analysis and sorting of polynucleotides based on size
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size. ...
05/08/2012
8142630Electrophoresis devices and methods for focusing charged analytes
Devices are provided for separating and focusing charged analytes, comprising a separation chamber and two or more electrodes, for example, an electrode array. A membrane separates the separation chamber and the electrodes. The separation chamber of the device is co...
03/27/2012
8142631Particle focusing apparatus and method for focusing particles by using the same
In a particle focusing apparatus and a method for focusing particles, the particle focusing apparatus includes a channel, a fixing member, a fluid feeding portion and a power supply. The channel has first and second ends and extends substantially in a line. The fixi...
03/27/2012
8105471Nanofluidics for bioseparation and analysis
The invention includes nanochannel devices and methods for using such nanochannel devices for separating molecules, ions and biomolecules. The nanochannel devices have at least one nanochannel through which fluid can move, wherein ionic double layers form in the flu...
01/31/2012
8083915Methods for forming small-volume electrical contacts and material manipulations with fluid microchannels
A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ioni...
12/27/2011
8080144Gradient elution electrophoresis
A method for performing electrophoretic separation of ionic compounds which involves varying a bulk fluid flow though a separation path into which ionic species are continuously introduced and separated. The method can also include the introduction of a leading elec...
12/20/2011
7988840Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the separation of particles according to size using an array comprising a networ...
08/02/2011
7988839Capillary electrophoresis systems and methods
An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality ...
08/02/2011
7955575Microfluidic surfaces
A microfluidic device comprising a set of one or more, preferably more than 5, covered microchannel structures manufactured in the surface of a planar substrate. The device is characterized in that a part surface of at least one of the microchannel structures has a ...
06/07/2011
7906001Method for separating proteins by capillary electrophoresis and buffer compositions for capillary electrophoresis
The invention concerns a free solution capillary electrophoresis method at alkaline pH for the analysis of samples comprising protein constituents including a lipoprotein constituent or constituents, characterized in that it comprises at least one step in which the ...
03/15/2011
7887686Method for analyzing haemoglobin by capillary electrophoresis, a kit for capillary electrophoresis, and use of a flow inhibitor in said method
The invention concerns a method for free solution capillary electrophoresis at an alkaline pH to analyze samples comprising haemoglobin, in which the sample is passed through a capillary containing an analysis buffer, comprising at least one step in which the sample...
02/15/2011
7857955Coated capillary electrophoresis tubes and system
The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to the inner capillary surface. The capillary tube has an inner surface th...
12/28/2010
7850834Electrophoresis method using capillary plate
In an electrophoresis method, a capillary plate having a capillary channel is maintained in a predetermined temperature to be processed, and a sample is filled into the capillary channel. A solution is prepared to have a temperature substantially the same as the pre...
12/14/2010
7846314Handling a plurality of samples
A method for handling samples in a microfluidic system is described. The microfluidic system includes an injection channel fluidically coupled to an injection point adapted for injecting an amount of fluid, a first sample well containing a first sample, the first sa...
12/07/2010
7837848Bidimensional separation by means of capillary electrophoresis carried out in a single capillary
A method for separating the constituents of a mixture M by electrophoresis in a single capillary includes (A) separating compounds of the mixture M in a single capillary according to the capillary electrophoresis technique; (B) isolating a fraction F of the compound...
11/23/2010
7833399Concentration method of fine particle dispersion and concentration apparatus of fine particle dispersion
The present invention provides a concentration method of a fine particle dispersion containing fine particles to be electrophoretically migrated, for concentrating the fine particle dispersion by allowing the fine particle dispersion to flow in a laminar flow in a c...
11/16/2010
7820023Preconcentration interface coupling liquid chromatography to capillary electrophoresis
An arrangement for two-dimensional separation of a complex analyte mixture is provided comprising a first separation device for the separation in a first dimension and a second device for the separation in the second dimension. In the area of the interface between t...
10/26/2010
7790007Electrophoresis chip, electrophoresis apparatus, and method for analyzing a sample
A sample which contains protein is stably maintained in a liquid state during electrophoresis. Electrophoresis chip 1 includes substrate 2, channels 5a to 5d which is provided on surface 3 of substrate 2 and wh...
09/07/2010
7736481Electrophoresis device and electrophoresis method
To reduce the elongation of the migration time for the first electrophoresis cycle in successive electrophoresis cycles and improve the reliability of electrophoresis analysis. The present invention relates to making the condition of a migration medium at the start ...
06/15/2010
7731827Method for capturing charged molecules traveling in a flow stream
The invention relates to a method for capturing charged molecules of interest traveling in an electrolyte flow stream through an electrically non-conductive channel, comprising at least one anode and at least one cathode individually separated from said channel, but...
06/08/2010
7708873Induced-charge electro-osmotic microfluidic devices
This invention provides devices and apparatuses comprising the same, for efficient pumping and/or mixing of relatively small volumes of fluid. Such devices utilize nonlinear electrokinetics as a primary mechanism for driving fluid flow. Methods of cellular analysis ...
05/04/2010
7708872Actuator in a microfluidic system for inducing electroosmotic liquid movement in a micro channel
The present invention describes an actuator in a microfluidic system for inducing an electroosmotic liquid movement in a microchannel. ...
05/04/2010
7678254Microchip processing method and apparatus
The processing apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment par...
03/16/2010
7645369Separation method and device for protein mixtures
A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is...
01/12/2010
7625475Nanotube fluid pump
A microfluidic pump has an outer housing such as a capillary tube, a nanotube, and an ionic fluid or alcohol. The nanotube is placed inside the capillary tube, and the capillary tube is filled with the ionic fluid or alcohol. A voltage source is connected to the nan...
12/01/2009
7578916Emulsions of ionic liquids
The present teachings provide emulsions using ionic liquids for separation of biomolecules and related methods, compositions, and devices. ...
08/25/2009
7578915Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis
A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction a...
08/25/2009
7465381Electrokinetic molecular separation in nanoscale fluidic channels
A method for separation of mixtures in fluidic systems through electrokinetic transport by use of nanochannels when the fluidic systems approach the size of an electrical double layer, thereby allowing separation based on charge. The disclosed apparatus comprises a ...
12/16/2008
7459068Multi-capillary electrophoresis apparatus
A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The multi-capillary electrophoresis apparatus can contain a multi-capillary array th...
12/02/2008
7459069Electrophoresis device and the use thereof
The invention relates to a device for electrophoretically separating molecules. The inventive device comprises: at least one plate having a top side and an underside; a first separating channel provided for receiving at least one first separating medium; at least on...
12/02/2008
7439075Method and device for withdrawing suspended microparticles from a fluidic microsystem
A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the micro...
10/21/2008
7425254Fractionation of macro-molecules using asymmetric pulsed field electrophoresis
A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field having two different fields at different orientations is applied. The alt...
09/16/2008
7422669Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
A microfluidic device and method for forming and dispensing minute volume segments of a material are described. In accordance with the present invention, a microfluidic device and method are provided for spatially confining the material in a focusing element. The de...
09/09/2008
7413642Material separation device
A separating device for use in separating electrically charged components, e.g., by electrophoresis, comprises a channel branched at a branch point to provide a main feed channel (105) connected to at least two subsidiary channels (110, 115). In use, d...
08/19/2008
7410559Electrophoresis methods
A separation carrier comprising β-1,3-glucan and/or methyl cellulose; a running buffer comprising the separation carrier; a method of capillary electrophoresis or microchip electrophoresis, wherein a sample comprising macromolecular compounds is run in the presence...
08/12/2008
7396444Device to operate a laboratory microchip
In a device to operate and handle a laboratory microchip to chemically process or analyze substances, the microchip is on a chip holder (41) that is part of a first assembly (42). The first assembly (42) also has an optical device (43) fo...
07/08/2008
7384525Electrophoretic analysis system having in-situ calibration
An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration coefficients map a spectrum of received channel intensities onto values ref...
06/10/2008
7368728Ionization source for mass spectrometry analysis
A new ionization source named Surface Activated Chemical Ionization (SACI) has been discovered and used to improve the sensitivity of the mass spectrometer. According to this invention the ionization chamber of a mass spectrometer is heated and contains a physical n...
05/06/2008
7364647Laminated flow device
A laminated flow device comprises a porous material encapsulated within bonding material. The porous material forms a flow path and the bonding material forms an enclosure surrounding the flow path. Micro-components, such as capillaries, electrodes, reservoirs, brid...
04/29/2008
7361259Capillary array and electrophoresis apparatus, and method
A capillary electrophoresis device including a capillary array, and a method of manufacturing the capillary array, are provided. During the manufacture of the capillary array, a plurality of capillaries are arranged in a substantially parallel arrangement and are fi...
04/22/2008
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