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| Number | Title | Issue Date |
| 8168051 | Sensor for determination of glucose A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive... | 05/01/2012 |
| 7410709 | Bio-battery A bio-battery includes a biomolecular energy source, a first electrode and a second electrode. In some configurations, a bio-battery may also include a first cell containing the first electrode and the biomolecular energy source, and a second cell having a reducible... | 08/12/2008 |
| 7332313 | Electrical wounding assay for cells in vitro A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be w... | 02/19/2008 |
| 7291256 | Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays Mediator stabilized reagent compositions and methods for their use in electrochemical analyte determination assays are provided. The subject reagent compositions include an enzyme, a redox mediator and a mediator-stabilizing buffer. Optionally, the reagent compositi... | 11/06/2007 |
| 7267751 | Programmable multiplexed active biologic array The present invention is directed to devices and methods for carrying out and/or monitoring biological reactions in response to electrical stimuli. A programmable multiplexed active biologic array includes an array of electrodes coupled to sample-and-hold circuits. ... | 09/11/2007 |
| 7235170 | Biosensor A biosensor that is highly responsive and capable of rapid and highly sensitive quantification of a specific component contained in a sample is provided. The biosensor of this invention comprises: an electrically insulating base plate; an electrode system comprising... | 06/26/2007 |
| 7118910 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at th... | 10/10/2006 |
| 7041492 | Extracellular recording electrode A multiple electrode includes a plurality of micro-electrodes provided on a substrate, and a wiring portion for providing an electrical signal to the micro-electrodes or extracting an electrical signal from the micro-electrodes. Each micro-electrode has porous condu... | 05/09/2006 |
| 6991906 | Method and device for measuring, calibrating and using laser tweezers To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical fi... | 01/31/2006 |
| 6770472 | Direct DNA sequencing with a transcription protein and a nanometer scale electrometer The present invention provides an apparatus and method for nucleotide or DNA sequencing by monitoring the molecular charge configuration as the DNA moves through a protein that is capable of transcribing the DNA. The apparatus and method provides a nanoscale electro... | 08/03/2004 |
| 6767731 | Electron induced fluorescent method for nucleic acid sequencing An apparatus, compositions and related methods for sequencing a target nucleic acid are described. In certain embodiments, the apparatus is a microfluidic apparatus comprising an input chamber, microchannel, output chamber and a detection unit that is operatively co... | 07/27/2004 |
| 6756223 | Electro-chemical analysis device with integrated thermal sensor and method for monitoring a sample using the device An electro-chemical analysis device and method for analyzing biomolecular samples, including a means for holding a sample on a substrate platform, a thermal sensor, a biosensor formed having a specific spatial resolution as related to the thermal sensor, and a means... | 06/29/2004 |
| 6730199 | Apparatus for measuring the electrophysiological activity of a group of cells The invention concerns an apparatus (10) comprising essentially a support (11) wherein is placed a measuring card (12), a perfusion device (13), a thermostat (14), a measuring box (15) and a measurement management system ( | 05/04/2004 |
| 6692952 | Cell analysis and sorting apparatus for manipulation of cells A cell analysis and sorting apparatus is capable of monitoring over time the behavior of each cell in a large population of cells. The cell analysis and sorting apparatus contains individually addressable cell locations. Each location is capable of captur... | 02/17/2004 |
| 6537800 | Apparatus for automatically measuring minute membrane potential An apparatus for automatically measuring minute membrane potential, based on a technique developed for controlling a membrane denaturation reaction without using a physical shearing force, for example, a method of causing the destruction of membrane at a ... | 03/25/2003 |
| 6329161 | Subcutaneous glucose electrode A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucoses is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, ev... | 12/11/2001 |
| 6325904 | Nanoelectrode arrays An array of electrodes at the atomic or nano scale (nanoelectrodes) is built on a chip. The spatial distribution, height, width and electrochemical composition of the nanoelectrodes is varied, such that protein-specific electronic receptors are built dire... | 12/04/2001 |
| 6309526 | Biosensor A biosensor is fabricated by forming a metal film over the surface of a substrate through evaporation, sputtering or by gluing a metal foil, then splitting the metal film into three regions, and forming a reagent layer on an area of measuring electrode an... | 10/30/2001 |
| 6287452 | Electrode for the electrochemical detection of nitric oxide Nitric oxide-specific electrodes are useful for in situ detection of nitric oxide in biomedical applications and have at least a surface region thereof which is capable of forming complexes with nitric oxide, for example, nitrosyl complexes. The nitric ox... | 09/11/2001 |
| 6287438 | Sampling system for analytes which are fluid or in fluids and process for its production The invention concerns a sampling system and a process for its production. Such systems can easily be employed throughout in chemical and biochemical analysis. The sampling system should be simply constructed and universally usable alone and in combinatio... | 09/11/2001 |
| 6284478 | Subcutaneous glucose electrode A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, eve... | 09/04/2001 |
| 6284126 | Electrode with improved signal to noise ratio An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of ... | 09/04/2001 |
| 6284125 | Electrochemical cell A method for determining the concentration of a reduced (or oxidised) form of a redox species in an electrochemical cell of the kind comprising a working electrode and a counter electrode spaced from the working electrode by a predetermined distance, said... | 09/04/2001 |
| 6251260 | Potentiometric sensors for analytic determination A potentiometric electrode and method for the determination of an analyte in a sample by linearly correlating potential at the electrode with the concentration of the analyte in the sample.... | 06/26/2001 |
| 6179979 | Electrochemical cell A method of manufacture of a thin layer electrochemical cell (FIGS. 12, 14) comprising the steps of: forming an aperture (11) extending through a sheet (1) of electrically resistive material, said aperture defining a side wall of the cell; mounting a firs... | 01/30/2001 |
| 6146510 | Sensor cartridge for a fluid analyte analyzer The present invention is a sensor formed over a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentially negligible effect on the sensor. Only a ... | 11/14/2000 |
| 6121009 | Electrochemical analyte measurement system A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, eve... | 09/19/2000 |
| 6083710 | Electrochemical analyte measurement system A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, eve... | 07/04/2000 |
| 6083366 | Sensor There is disclosed a sensor for an analyte comprising a working electrode assembly, itself comprising a micro-electrode array in which each micro-electrode is coated with a layer of redox state dependent conducting organic polymer, a counter electrode; a ... | 07/04/2000 |
| 6051422 | Hybrid biosensors The invention relates to an apparatus and method for monitoring cells and to a method for monitoring changes in cells upon addition of an analyte to the cell's environment, comprising a device which includes an array of microelectrodes disposed in a cell ... | 04/18/2000 |
| 6046056 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for... | 04/04/2000 |
| 6030828 | Microsensor and use of such microsensor The invention relates to a microsensor for determining the concentration of a primary substrate by measuring the concentration of a secondary substrate. The microsensor comprises a transducer (1) for measuring the secondary substrate. The transducer (1) i... | 02/29/2000 |
| 6022463 | Sensors with subminiature through holes The present invention is a sensor having an electrode formed in electrical contact with a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentiall... | 02/08/2000 |
| 6001239 | Membrane based electrochemical test device and related methods An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor mate... | 12/14/1999 |
| 5944661 | Potential and diffusion controlled solid electrolyte sensor for continuous measurement of very low levels of transdermal alcohol A method for continuous tracking of blood alcohol, is comprised of 1) a potential- and diffusion-controlled electrochemical solid polymer electrolyte sensor that continuously and concurrently measures very low concentrations of ethanol vapor at the surfac... | 08/31/1999 |
| 5858452 | Method for fabricating wiring substrate with subminiature thru-holes The present invention is an electronic wiring substrate for sensors formed over a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentially neglig... | 01/12/1999 |
| 5810725 | Planar electrode A planar electrode which enables multi-point simultaneous stimulation and recording of nerve cells over a long time is provided, which also has excellent response property. An ITO film is evaporated on the whole surface of an insulating substrate of the h... | 09/22/1998 |
| 5719033 | Thin film transistor bio/chemical sensor A chemical sensor includes a thin film transistor with a gate positioned on one side. An insulating layer is positioned on the opposite side and an indicator film is positioned on the insulating layer in generally opposed relationship to the gate. Induced... | 02/17/1998 |
| 5698083 | Chemiresistor urea sensor A sensor to detect and quantify urea in fluids resulting from hemodialysis procedures, and in blood and other body fluids. The sensor is based upon a chemiresistor, which consists of an interdigitated array of metal fingers between which a resistance meas... | 12/16/1997 |
| 5653864 | Protein biosensor and method for protein measurement with the same A protein biosensor, which comprises an insulating substrate, a working electrode, a counter-electrode and a reference electrode, each electrodes provided on the insulating substrate, the working electrode comprising a first lead electrode and a thin prot... | 08/05/1997 |
