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| Number | Title | Issue Date |
| 8092662 | Redox polymers Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons fro... | 01/10/2012 |
| 7906000 | Analyzer and method of manufacturing the same The present invention relates to an analytical tool (X1) including a first and a second plate elements (1, 3), a flow path (4) defined between the plate elements (1, 3) and an exhaust port (31) for discharging gas from the flow pat... | 03/15/2011 |
| 7410709 | Bio-battery A bio-battery includes a biomolecular energy source, a first electrode and a second electrode. In some configurations, a bio-battery may also include a first cell containing the first electrode and the biomolecular energy source, and a second cell having a reducible... | 08/12/2008 |
| 7247448 | Method for gene expression The invention relates to a method for gene expression in a cell-free transcription/translation system, the reaction solution containing all the components necessary for the transcription/translation mechanism, amino acids, nucleotides, metabolic components which pro... | 07/24/2007 |
| 7211504 | Process and arrangement for the selective metallization of 3D structures A process is provided for the selective metallization of 3D structures, particularly for the selective gold-plating of 3D contact structures on wafers, such as contact bumps, which are electrically connected to a bond pad on the wafer via a three-dimensional, mechan... | 05/01/2007 |
| 6767441 | Biosensor with peroxidase enzyme An improved biosensor having at least a first working electrode and a first electrode material disposed on the first working electrode. The first electrode material is a mixture made by combining at least one enzyme where the at least one enzyme is a capable of reac... | 07/27/2004 |
| 6740215 | Biosensor A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron med... | 05/25/2004 |
| 6736957 | Biosensor electrode mediators for regeneration of cofactors and process for using The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme... | 05/18/2004 |
| 6551495 | Electrochemical assays Disclosed is a component for a device for detecting the presence of an analyte of interest in a sample, the component comprising an electrically conducting solid support having immobilized thereon a chemical moiety, said chemical moiety comprising an elec... | 04/22/2003 |
| 6440296 | Microstructured biosensor, use of the biosensor and process for the immobilization of biocatalysts A biosensor is used for measuring principal metabolites in blood and other substances. The biosensor has a special structure formed of a two-layer enzymatic membrane with a considerably increased functionality compared with enzymatic membranes of the prio... | 08/27/2002 |
| 6329161 | Subcutaneous glucose electrode A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucoses is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, ev... | 12/11/2001 |
| 6121009 | Electrochemical analyte measurement system A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, eve... | 09/19/2000 |
| 6083710 | Electrochemical analyte measurement system A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, eve... | 07/04/2000 |
| 6030827 | Microfabricated aperture-based sensor A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.... | 02/29/2000 |
| 5997817 | Electrochemical biosensor test strip An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes... | 12/07/1999 |
| 5972199 | Electrochemical analyte sensors using thermostable peroxidase A sensor for the detection and measurement of an analyte in a biofluid. The sensor includes two enzymes. One type of sensor measures the concentration of hydrogen peroxide using a thermostable peroxidase enzyme that is immobilized in a redox hydrogel to f... | 10/26/1999 |
| 5964993 | Glucose sensor A sensor that is capable of accurately measuring glucose and other analytes in low oxygen environments is provided. The sensor employs an enzyme-containing membrane comprising a semi-interpenetrating polymer network which is infiltrated by an enzyme. The ... | 10/12/1999 |
| 5876577 | Electrochemical oxygen sensor An electrochemical oxygen sensor comprises an impermeable substrate and a plurality of conductive layers applied thereto by thick film deposition. At least one conductive layer comprises an electrode and a conductor connected to the electrode. The electro... | 03/02/1999 |
| 5830341 | Electrodes and metallo isoindole ringed compounds The present invention provides for electrode assemblies and methods in which electron transfer between a redox reaction product and an electrically conductive electrode material is facilitated by a metallo macrocyclic compound, preferably a metallo isoind... | 11/03/1998 |
| 5795453 | Electrodes and metallo isoindole ringed compounds The present invention provides for electrode assemblies and methods in which electron transfer between a redox reaction product and an electrically conductive electrode material is facilitated by a metallo macrocyclic compound, preferably a metallo isoind... | 08/18/1998 |
| 5795774 | Biosensor A drop in measurement accuracy of biosensors, due to interferents in a measurement sample is avoided by an arrangement wherein: a hydrogen peroxide electrode 2 is formed on an insulated base 1, and then a γ-aminopropyltriethoxysilane film 3, an acetylcel... | 08/18/1998 |
| 5779867 | Dry chemistry glucose sensor A self contained glucose sensor is provided that generally comprises a strip type glucose sensing electrode having an active surface comprising an organic conducting redox salt dispersed in a polymeric membrane, with the membrane coating a conductive stri... | 07/14/1998 |
| 5776324 | Electrochemical biosensors An electrochemical biosensor for determining the level of a target chemical in a biological fluid includes an electrochemical system including a enzyme substrate which reacts with the target chemical to yield a system signal related to the concentration i... | 07/07/1998 |
| 5766934 | Chemical and biological sensors having electroactive polymer thin films attached to microfabricated devices and possessing immobilized indicator moieties Chemical and biological sensors are provided that convert the chemical potential energy of an analyte into a proportionate electrical signal through the transducer action of a microfabricated device with an integral electroconductive polymer film. The mic... | 06/16/1998 |
| 5723345 | Method and device for specific binding assay The present invention provides a general purpose specific binding assay method which has the advantages of highly accurate and quick measurements which exclude the effects of various factors that decrease reliability of the measured values, such as non-sp... | 03/03/1998 |
| 5674696 | Apparatus for the determination of a trace amount of an analyte substance or organism There is disclosed an apparatus for the determination of a trace amount of an analyte substance or organism. A substrate solution is brought into contact with a small diameter tube which has captured, at least on its inner surface, a trace amount of an an... | 10/07/1997 |
| 5651869 | Biosensor The biosensor of this invention includes an electrically insulating substrate; an electrode system formed on the substrate which includes a working electrode and a counter electrode; and a reaction layer formed on the substrate or above the substrate with... | 07/29/1997 |
| 5645710 | Glucose sensor and assay method A redox electrode for the rapid detection of glucose in aqueous media and a method for its use are provided. The redox electrode comprises an electrically conductive member such as copper, and a redox membrane in direct contact with said electrically cond... | 07/08/1997 |
| 5643721 | Bioreagent immobilization medium The present invention provides an immobilization medium which can immobilize bioreagents to support materials and which dries to a water resistant layer or film. The immobilization medium comprises (i) a liquid or fluid binding reagent and (ii) complexes ... | 07/01/1997 |
| 5607565 | Apparatus for measuring analytes in a fluid sample A method and apparatus provide a system for measuring a measurable component in a sample. A sample is introduced into a chamber. A permeable membrane to the measurable component allows the component to pass into a second chamber. In the second chamber the... | 03/04/1997 |
| 5601694 | Electrochemical sensors A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t... | 02/11/1997 |
| 5582698 | Sensor package A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t... | 12/10/1996 |
| 5573649 | Miniaturized oxygen electrode and process of producing same The miniaturized oxygen electrode having a small size exceeding the limit of miniaturization of the prior art electrode comprises an insulating substrate 21, 31 and, provided thereon, a pair of electrode patterns 22, 23 each comprising an active section 2... | 11/12/1996 |
| 5543024 | Glucose sensitive FET sensor and method of making same A glucose sensitive FET sensor is provided which includes a substrate, a source electrode formed in the substrate, a drain electrode formed in the substrate, a hydrogen ion sensitive film formed on the substrate to cover the source electrode and the drain... | 08/06/1996 |
| 5466575 | Process for the manufacture of wholly microfabricated biosensors An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional feat... | 11/14/1995 |
| 5431160 | Miniature implantable refillable glucose sensor and material therefor A reusable, miniature, implantable electrochemical sensor, a method of making the same, and a powder therefor are provided. Enzyme material is immobilized on bulk particulate matter, and a reaction chamber of the sensor is then filled therewith. The senso... | 07/11/1995 |
| 5391272 | Electrochemical immunoassay methods An electro-immunosensor which can be used to determine the presence of a wide range of analytes in solution is described. Also described are methods of determining subnanogram levels of analytes in a one-step procedure. This novel immunosensor comprises a... | 02/21/1995 |
| 5387328 | Bio-sensor using ion sensitive field effect transistor with platinum electrode A bio-sensor employs an ion senstive field effect transistor (ISFET) comping a source 1 and a drain 3 formed in a substrate, an ion sensitive gate 2 placed between the source 1 and drain 3, an ion sensitive film 4 formed on the ion sensing gate 2, an imm... | 02/07/1995 |
| 5272087 | Enzymatic electrode and its preparation method An enzymatic electrode, having a homogeneous composition throughout, consists essentially of a uniform intimate admixture of a conducting powder with at least one immobilized enzyme, or with an immobilized enzyme and a mediator agent or a co-enzyme, in a ... | 12/21/1993 |
| 5227042 | Catalyzed enzyme electrodes An enzyme electrode is prepared with a composite coating on an electrical conductor. The composite coating is formed from a casting solution of a perfluorosulfonic acid polymer, an enzyme, and a carbon supported catalyst. The solution may be cast directly... | 07/13/1993 |
