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| Number | Title | Issue Date |
| 8172994 | Biomaterial measuring device and manufacturing method thereof A method of producing a biomaterial measuring device is disclosed. The method includes forming a plurality of reactions elements, to which an assay reagent is applied, on a first substrate, cutting the resulting first substrate in a unit of individual reaction eleme... | 05/08/2012 |
| 8043489 | Multi-layer strip for use in measuring biological material and system for measuring biological material The multi-layer strip for use in measuring biological material and the system for measuring a biological material are provided, wherein the multi-layer strip includes a stack of a plurality of strips, each having a flow channel and a reaction unit, and the strips ma... | 10/25/2011 |
| 7837845 | Sensor card for determining analytes in liquid or gas samples and method for producing such a sensor card A sensor card for determining analytes in liquid and gas samples with films connected to one another in sheetlike fashion, namely a sensor film facing the sample with openings and a covering film remote from the sample with openings for electrical tapping, at least ... | 11/23/2010 |
| RE41264 | Biosensor with peroxidase enzyme An improved biosensor having at least a first working electrode and a first electrode material disposed on the first working electrode. The first electrode material is a mixture made by combining at least one enzyme where the at least one enzyme is a capable of reac... | 04/27/2010 |
| 7410709 | Bio-battery A bio-battery includes a biomolecular energy source, a first electrode and a second electrode. In some configurations, a bio-battery may also include a first cell containing the first electrode and the biomolecular energy source, and a second cell having a reducible... | 08/12/2008 |
| 7378007 | Combined lancet and electrochemical analyte-testing apparatus An apparatus for detection and quantitation of an electrochemically-detectable analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the la... | 05/27/2008 |
| 7379765 | Oxygen enhancing membrane systems for implantable devices The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a cata... | 05/27/2008 |
| 7371247 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe... | 05/13/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7343188 | Devices and methods for accessing and analyzing physiological fluid Systems, devices and methods for determining the concentration of physiological fluid analytes are provided. The subject systems have a plurality of biosensor devices present on a disposable cartridge. Each biosensor device includes a biosensor and a skin penetratio... | 03/11/2008 |
| 7331931 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato... | 02/19/2008 |
| 7323098 | Biosensor and measuring method using the same A biosensor capable of measuring the concentration of one or more specific substances in one or more sample solutions almost simultaneously is provided. The biosensor comprises a plurality of sensor units, and each of the sensor units comprises an electrode system i... | 01/29/2008 |
| 7323140 | Moving microdroplets in a microfluidic device The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms ... | 01/29/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7312087 | Devices and methods for biochip multiplexing The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a ... | 12/25/2007 |
| 7300802 | Membrane strip biosensor system for point-of-care testing The present invention relates to a biosensor for point-of-care testing (POCT) whose detection sensitivity was remarkably improved by introducing to membrane strip chromatographic assay system a successive cross-flow procedure for immune reaction and enzymatic reacti... | 11/27/2007 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7273541 | Microfluid device and synthetic methods A method of electrolytic synthesis comprises applying a potential between a first electrode and a second electrode. The first electrode is in contact with a first fluid stream in a channel, the second electrode is in contact with a second fluid stream in the channel... | 09/25/2007 |
| 7267751 | Programmable multiplexed active biologic array The present invention is directed to devices and methods for carrying out and/or monitoring biological reactions in response to electrical stimuli. A programmable multiplexed active biologic array includes an array of electrodes coupled to sample-and-hold circuits. ... | 09/11/2007 |
| 7258693 | Device and method for variable speed lancet A method of penetrating tissue is provided. The method comprises using a lancet driver to advance a lancet into the tissue; advancing the lancet at a first desired velocity in a first layer of tissue; advancing the lancet at a second desired velocity in a second lay... | 08/21/2007 |
| 7258673 | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein An interstitial fluid (ISF) extraction device includes a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom and at least three concentrically-... | 08/21/2007 |
| 7244265 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member alo... | 07/17/2007 |
| 7238160 | Apparatus for measuring biological component The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus. The puncture mechanism includes a punctu... | 07/03/2007 |
| 7238534 | Capillary active test element having an intermediate layer situated between the support and the covering The invention concerns a device for withdrawing samples of liquid samples for analytical elements. The capillary-device channel is essentially formed by a carrier, a cover and optionally an intermediate layer between the cover and carrier. A notch is located in one ... | 07/03/2007 |
| 7232451 | Method and apparatus for penetrating tissue A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performanc... | 06/19/2007 |
| 7229458 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of cartridges each with a distal port and a proximal port. A plurality of penetrating members are provided, each coupled to a cartridge and having a sharpened distal tip and a shaft portion slidably disposed within th... | 06/12/2007 |
| 7226461 | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend ou... | 06/05/2007 |
| 7225008 | Multiple use analyte sensing assembly A method of making a multiple use analyte sensing assembly. The method includes placing a coated wire analyte sensing assembly on an article having a surface that defines a set of pockets so that the wire extends into each pocket. The coated wire is then typically c... | 05/29/2007 |
| 7198606 | Method and apparatus for a multi-use body fluid sampling device with analyte sensing A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of penetrating members are coupled to a single cartridge and are operatively couplable to the penetrating member driver. The penetrating members are movable to extend radi... | 04/03/2007 |
| 7192752 | Real time electronic cell sensing systems and applications for cell-based assays The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, ... | 03/20/2007 |
| 7189370 | Apparatus and methods for high throughput and high-resolution assays An apparatus integrates one dimensional separation to another dimensional separation and automates the operation of the two dimensional separation. The first dimensional separation is performed in one column while the second dimensional separation is performed in mu... | 03/13/2007 |
| 7176016 | High throughput method and system for screening candidate compounds for activity against target ion channels Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields ... | 02/13/2007 |
| 7172897 | Devices and methods for biochip multiplexing The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysi... | 02/06/2007 |
| 7120483 | Methods for analyte sensing and measurement A method of measuring an analyte concentration in body fluid. The method includes the use of an analyte measuring device that has an analyte sensing element with a sharpened distal end and further has an indicating electrode covered by an absorbent layer. Also, an e... | 10/10/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7112433 | Electrical analysis of biological membranes A biochip device for electrical analysis of biological membranes. The device may include a substrate assembly defining an array of apertures and including thin-film devices configured to sense an electrical property of biological membranes that seal the apertures. T... | 09/26/2006 |
| 7101472 | Microfluidic ion-selective electrode sensor system Ion-selective electrode sensor systems, and methods of fabricating such systems, may be utilized to analyze microfluidic sample volumes, i.e., sample volumes on the order of 1 to 1000 microliters. ... | 09/05/2006 |
| 7094354 | Method and apparatus for separation of particles in a microfluidic device A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has... | 08/22/2006 |
| 7041492 | Extracellular recording electrode A multiple electrode includes a plurality of micro-electrodes provided on a substrate, and a wiring portion for providing an electrical signal to the micro-electrodes or extracting an electrical signal from the micro-electrodes. Each micro-electrode has porous condu... | 05/09/2006 |
| 7041068 | Sampling module device and method A tissue penetration device and method of using same that may include a lancet module or sampling module. The sampling module may optionally be in a cartridge configuration and include sampling and analyzing functions, which may be integrated. ... | 05/09/2006 |
