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| Number | Title | Issue Date |
| 5002754 | Technetium (III/II) imaging agents A ligated technetium (III/II) complex is useful as a brain perfusion imaging agent. The complex has a technetium (III/II) center surrounded by six ligating moieties. The complex preferably has a reduction potential Tc(III) to Tc(II) which is less than abo... | 03/26/1991 |
| 4994259 | Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives Manganese(II) chelates of N,N'-bis-(pyridoxal)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-arylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-alkylenediamine-N... | 02/19/1991 |
| 4992554 | Dipyridoxyl phosphate chelating compounds N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monoph... | 02/12/1991 |
| 4992555 | Certain dipyridylphosphate chelatable compounds capable of forming metal ion chelates N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monoph... | 02/12/1991 |
| 4963682 | Novel radiopharmaceuticals and chelating agents useful in their preparation A dihydropyridine.rarw..fwdarw. pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radionuclide to the brain is provided. A chelating agent capable of chelating with a radionuclide and havi... | 10/16/1990 |
| 4954645 | Dithioacid rhenium sulfide dimer compositions Briefly stated, the present invention encompasses a new class of rhenium 1,1-dithioacid complexes and their method of preparation. The complexes have the general formula [L2 Re(μ-S)]2 wherein L is a dithioacid or similar ligand, and... | 09/04/1990 |
| 4935518 | Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof Managanese(II) chelates of N,N'-bis-(pyridoxal)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-arylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-alkylenediamine-... | 06/19/1990 |
| 4933456 | Dipyridoxyl phosphate NMRI contrast agents N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monoph... | 06/12/1990 |
| 4916214 | Cationic complexes of technetium-99m The invention concerns cationic complexes of Technetium-99m with bidentate ligands (L), including complexes having the formulae [Tc(NO) X L2 ]+ and [Tc L3 ]+, which are of interest as heart imaging agents. The ... | 04/10/1990 |
| 4888032 | Salts of cationic-metal dry cave complexes Salts containing cations of the formula: ##STR1## (in which M is Co, Fe, Cr or Mn, X, Y, R1, The Government has rights in this invention pursuant to Contract Number CHE-75-14837 awarded by the National Science Foundation.... | 12/19/1989 |
| 4885363 | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs Metal-chelating liquids having the formula ##STR1## wherein Y is oxygen or ##STR2## R1 is hydrogen, alkyl, arylalkyl aryl, alkoxy, hydroxyalkyl ##STR3## wherein G is ##STR4##... | 12/05/1989 |
| 4880007 | Contrast agent for NMR scanning Complexes formed between (a) an amino di- or poly-phosphonate in which phosphonate groups comprise separate carbon atoms and (b) a paramagnetic metal ion such as Gd3+, have calcified tissue seeking properties which make them useful as contrast ... | 11/14/1989 |
| 4872561 | Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is s... | 10/10/1989 |
| 4871836 | Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes Boronic acid adducts of radioactive isotopes of rhenium dioxime complexes are useful for labeling biologically active compounds as agents for radiotherapy. These boronic acid adducts of radioactive isotopes of rhenium dioxime complexes have the formula I.... | 10/03/1989 |
| 4863716 | Determination of fallopian tubal patency by magnetic resonance imaging This invention is a method for obtaining improved NMR images of the uterine cavity and fallopian tubes comprising imjecting a physiologically acceptable solution of a chelate of a parmagnetic material into the uterus under sufficient pressure to cause the... | 09/05/1989 |
| 4849511 | Technetium chelates to be used for determining the renal function The invention relates to a technetium chelate of the general formula ##STR1## wherein X is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an... | 07/18/1989 |
| 4845039 | Method of labeling amine-containing compounds with a metal Method for labelling amine-containing compounds like proteins with a metal, particularly technetium-99m comprising reacting metal ions in an acidic medium with a compound represented by formulae (I) or (II), wherein R1, R2 and R... | 07/04/1989 |
| 4842845 | Radioactive metal chelates for dipyridoxyl phosphate Radioactive metal ion chelates of N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacet... | 06/27/1989 |
| 4822925 | Organosalts of metalate anions and process for the production of alkylene glycols therewith Novel vicinal dioxyalkylene organometalates comprising a cation having a hydrocarbyl-containing substituent are disclosed. The vicinal dioxyalkylene organometalates can be reacted with water to yield alkylene glycols.... | 04/18/1989 |
| 4818813 | Complexes of Technetium 99m with propylene amine oximes Novel propylene amine oxime ligands have the formula ##STR1## where each of R1, R2, R3, R4, R5, R6, R7 or R8 may be hydrogen, hydrocarbon, carboxyl, amine, amide or ... | 04/04/1989 |
| 4795626 | 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo A cationic 99m TcIII myocardial imaging agent is disclosed which has a relatively negative redox potential. This prevents in vivo reduction of the Tc(III) to Tc(II). The redox potential of the Tc(III) is controlled by complexing the ... | 01/03/1989 |
| 4789543 | Neutral technetium 99-m complexes useful as radiodiagnostic agents An hepatobiliary imaging agent is disclosed which is a neutral complex of Tc-99m, a complexing ion, SO2, and a mono or polydentate organic ligand having one or more donor atoms for complexing with TC-99m to form the neutral complex.... | 12/06/1988 |
| 4781912 | Cationic complex of technetium-99m. The invention relates to a cationic complex of technetium-99m with (a) at least one bidendate ligand X having the formula where each Z is phosphorus or arsenic, Q is a (CH2)n linking group where n is 2 to 8 or a 1,2-phenylene linking group, e... | 11/01/1988 |
| 4775419 | Metal amine complexes for improving the bond strength properties of asphalt Metal amine complexes are formed from amines adhering to the general formulas ##STR1## by reaction with various metal salts. Prior to reaction with various metal salts, the above amines may first be reacted with a formaldehyde source or with a f... | 10/04/1988 |
| 4764633 | Ferric ion catalyzed complexation of zinc and/or manganese with alpha amino acids A method of making 1:1 complex salts of alpha amino acids and a metal ion which is either zinc or manganese, the method comprising reacting a water soluble zinc salt or manganese salt with an alpha amino acid in the presence of catalytically effective amo... | 08/16/1988 |
| 4758422 | Ferrioxamine paramagnetic contrast agents for MR imaging In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through the subject, and after a time interval taking an NMR image ... | 07/19/1988 |
| 4735793 | Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected ... | 04/05/1988 |
| 4714605 | Technetium-99m labeled dioxime complexes Technetium-99m labeled dioxime complexes are useful for imaging the myocardium, brain and hepatobiliary system, in humans and other mammalian species.... | 12/22/1987 |
| 4705849 | Boronic acid adducts of technetium-99m dioxime complexes Boronic acid adducts of technetium-99m dioxime complexes are useful for imaging the myocardium, hepatobiliary system, brain and blood pool in humans and other mammalian species.... | 11/10/1987 |
| 4673562 | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide 99m Tc suitable for administration as a radiopharmaceutical to obtain images ... | 06/16/1987 |
| 4670545 | Chelating agents for technetium-99M The present invention relates to a novel family of Technetium chelating agents (ligands) based upon amide and mercaptide donor groups.... | 06/02/1987 |
| 4667045 | Organosalts of metalate anions and process for the production of alkylene glycols therewith Novel vicinal dioxyalkylene organometalates comprising a cation having a hydrocarbyl-containing substituent are disclosed. The vicinal dioxyalkylene organometalates can be reacted with water to yield alkylene glycols.... | 05/19/1987 |
| 4657903 | Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures u... | 04/14/1987 |
| 4655949 | Lubricating oil compositions containing organometallic additives This invention provides novel lubricating oil compositions comprising an organometallic additive, including a metal selected from Groups I, Ib, and VIII of the Periodic System of Elements, e.g. Na, K, Cu, Co, Ni or Fe, chelated with the reaction product o... | 04/07/1987 |
| 4652647 | Aromatic-metal chelate compositions Disclosed are aromatic-metal chelate compositions which are deficient in hydrogen, are cross-linked, and which are comprised of two or more heteroatoms, wherein at least one of the heteroatoms are part of a 5 to 6 member heterocyclic ring, and wherein the... | 03/24/1987 |
| 4617184 | 99m Tc-1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane complex for skeleton scanning A chemical complex of Tc-99m with 1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane is skeleton specific. The complex can be made by reducing pertechnetate ion and reacting the reduced technetium species with 1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethan... | 10/14/1986 |
| 4615876 | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reduc... | 10/07/1986 |
| 4568360 | Mixed organometallic compositions comprising elements from the lanthanide group and manganese or elements from the iron group, process for the preparation of said compositions, and their use as fuel additives A mixed organometallic composition suitable for use as fuel additives contains an organic acid salt of at least one metal from the lanthanide group and of at least one metal selected from the group formed by manganese and the metals of the iron group wher... | 02/04/1986 |
| 4546195 | Process for the production of amino-dicarboxylic acid-bivalent metal-halogen complexes and such complexes The invention concerns a novel process for the production of a complex cound comprising an amino-dicarboxylic acid ion component, a bivalent metal ion component, and a halogen ion component, which comprises the step of reacting together in an aqueous med... | 10/08/1985 |
| 4522932 | Phosphine and phosphonium compounds and catalysts Novel ligand materials and transition metal complexes thereof are disclosed which are useful as solvents and/or catalysts for various processes, including catalytic conversion processes for the conversion of hydrocarbons or carbon monoxide, such as the hy... | 06/11/1985 |
